Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-24T23:51:29.465Z Has data issue: false hasContentIssue false

Chapter 31 - In Vitro Maturation of Germinal Vesicle Oocytes

from Section 8 - In Vitro Follicle Culture

Published online by Cambridge University Press:  27 March 2021

By
Michel De Vos
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
Get access

Summary

The field of female fertility preservation is based on the ability to successfully cryopreserve ovarian tissue [1], and this can now be offered to a wide range of patients worldwide [2, 3]. Fragments of cryopreserved ovarian cortex can be thawed and autografted to an orthotopic or heterotopic site to restore fertility [4, 5]. The potential of this tissue to restore fertility would be greatly enhanced if immature oocytes contained within the tissue could be grown to mature stages within the laboratory and this would be particularly beneficial for prepubertal girls who currently have fewer options to preserve and restore their fertility than adult women [2, 3].

Cryopreserved tissue contains the most immature stage of oocyte within primordial follicles and the main aim of culturing this tissue is to support in vitro gametogenesis/growth (IVG) to develop immature oocytes entirely in vitro [6]. If this methodology could be demonstrated to be safe, it would maximize the potential of cryopreserved ovarian tissue and have many clinical applications [2, 3].

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 355 - 363
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Delvigne, A, Rozenberg, S. Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS). Hum Reprod Update, 2003;9:77–96.Google Scholar
Delvigne, A, Rozenberg, S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Hum Reprod Update, 2002;8:559–577.Google Scholar
Child, TJ, Abdul-Falil, AK, Gulekli, B et al. In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome. Fertil Steril, 2001;76:936–942.CrossRefGoogle ScholarPubMed
Engmann, L, DiLuigi, A, Schmidt, D et al. The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled study. Fertil Steril, 2008;89:84–91.Google Scholar
Trounson, A, Wood, C, Kausche, A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril, 1994;62:353–362.Google Scholar
Ho, VNA, Pham, TD, Le, AH, Ho, TM, Vuong, LN. Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome. J Ovarian Res, 2018 August 27;11(1):767–711.Google Scholar
Smitz, J, Picton, HM, Platteau, P et al. Principal findings from a multicenter trial investigating the safety of follicular-fluid meiosis-activating sterol for in vitro maturation of human cumulus-enclosed oocytes. Fertil Steril, 2007;87:949–964.Google Scholar
Banwell, KM, Thompson, JG. In vitro maturation of mammalian oocytes: outcomes and consequences. Semin Reprod Med, 2008;26:162–174.Google Scholar
Filali, M, Hesters, L, Franchin, R et al. Retrospective comparison of two media for in vitro maturation of oocytes. Reprod Biomed Online, 2008;16:250–256.Google Scholar
Fadini, R, Dal Canto, MB, Mignini Renzini, M et al. Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study. Reprod Biomed Online, 2009;19:343–351.Google Scholar
Mikkelsen, AL, Smith, S, Lindenberg, S. Possible factors affecting the development of oocytes in in vitro maturation. Hum Reprod, 2000;15:11–17.Google Scholar
Nogueira, D, Ron-El, R, Friedler, S et al. Meiotic arrest in vitro by phosphodiesterase 3-inhibitor enhances maturation capacity of human oocytes and allows subsequent embryonic development. Biol Reprod, 2006;74:177–184.CrossRefGoogle ScholarPubMed
Albuz, FK, Sasseville, M, Lane, M et al. Simulated physiological oocyte maturation (SPOM): a novel in vitro maturation system that substantially improves embryo yield and pregnancy outcomes. Human Reproduction, 2010 December;25(12):2999–3011.Google Scholar
Sanchez, F, Lolicato, F, Romero, S et al. An improved IVM method for cumulus-oocyte complexes from small follicles in polycystic ovary syndrome patients enhances oocyte competence and embryo yield. Hum Reprod, 2017 August 30;32(10):2056–2068.Google Scholar
Park, JY, Su, YQ, Ariga, M et al. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science, 2004;303:682–684.CrossRefGoogle ScholarPubMed
Pincus, G, Enzmann, EV. The comparative behaviour of mammalian eggs in vitro and in vivo.II The activation of tubal eggs in the rabbit. J Exp Med, 1935;62:665–675.Google Scholar
Edwards, RG, Bavister, BD, Steptoe, PC. Early stages of fertilization in vitro of human oocytes matured in vitro. Nature, 1969;221:632–635.Google Scholar
Cha, KY, Koo, JJ, Ko, JJ et al. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril, 1991;55:109–113.Google Scholar
Chian, RC, Gulekli, B, Buckett, WM et al. Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome. N Engl J Med, 1999;341:1624–1626.CrossRefGoogle Scholar
Chian, RC, Buckett, WM, Tan, SL. In-vitro maturation of human oocytes. Reprod Biomed Online, 2004;8:148–166.Google Scholar
Suikkari, AM, Söderström-Anttila, V. In-vitro maturation of eggs: is it really useful? Best Pract Res Clin Obst Gyn, 2007;21:145–155.Google Scholar
de Paula Martins, W, dos Reis, RM, Ferriani, RA et al. Endometrial preparation for in vitro oocyte maturation: early use of estrogen increases endometrial tissue and requires lower daily dosage: a cross over trial in ‘mock’ cycles. J Assist Reprod Genet, 2006;23:241–246.CrossRefGoogle Scholar
Walls, ML, Hunter, T, Ryan, JP et al. In vitro maturation as an alternative to standard in vitro fertilization for patients diagnosed with polycystic ovaries: a comparative analysis of fresh, frozen and cumulative cycle outcomes. Hum Reprod, 2015;30:88–96.Google Scholar
De Vos, M, Smitz, J, Thompson, JG, Gilchrist, RB. The definition of IVM is clear—variations need defining. Hum Reprod, 2016 October 21;31(11):2411–2415.Google Scholar
Gilchrist, RB, Thompson, JG. Oocyte maturation: emerging concepts and technologies to improve developmental potential in vitro. Theriogenology, 2007;67:6–15.Google Scholar
Edwards, RG. Maturation in vitro of human ovarian oocytes. Lancet, 1965;2 926–929.Google Scholar
Eppig, JJ. The participation of cyclic adenosine monophosphate (cAMP) in the regulation of meiotic maturation of oocytes in the laboratory mouse. J Reprod Fertil Suppl, 1989;38:3–8.Google Scholar
Dekel, N. Regulation of oocyte maturation. The role of cAMP. Ann NY Acad Sci, 1988;541:211–216.Google Scholar
Thomas, RE, Armstrong, DT, Gilchrist, RB. Bovine cumulus cell-oocyte gap junctional communication during in vitro maturation in response to manipulation of cell-specific cyclic adenosine 30, 50-monophosophate levels. Biol Reprod, 2004;70:548–556.CrossRefGoogle Scholar
35. Thomas, RE, Thompson, JG, Armstrong, DT et al. Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. Biol Reprod, 2004;71:1142–1149.Google Scholar
Luciano, AM, Modina, S, Vassena, R et al. Role of intracellular cyclic adenosine 30, 50- monophosphate concentration and oocyte-cumulus cells communications on the acquisition of the developmental competence during in vitro maturation of bovine oocyte. Biol Reprod, 2004;70: 465–472.Google Scholar
Mottershead, DG, Sugimura, S, Al-Musawi, SL et al. Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-β family, is a potent activator of granulosa cells and improves oocyte quality. J Biol Chem, 2015 September 25;290(39):24007–24020.Google Scholar
Zeng, H-T, Ren, Z, Guzman, L et al. Heparin and cAMP modulators interact during pre-in vitro maturation to affect mouse and human oocyte meiosis and developmental competence. Hum Reprod,. 2013 June;28(6):1536–1545.Google Scholar
Sanchez, F, Lolicato, F, Romero, S et al. An improved IVM method for cumulus-oocyte complexes from small follicles in polycystic ovary syndrome patients enhances oocyte competence and embryo yield. Hum Reprod, 2017 October 1;32(10):2056–2068.Google Scholar
Grynberg, M, Poulain, M, le Parco, S et al. Similar in vitromaturation rates of oocytes retrieved during the follicular or luteal phase offer flexible options for urgent fertility preservation in breast cancer patients. Hum Reprod, 2016;31(3):623–629.Google Scholar
Creux, H, Monnier, P, Son, W-Y, Buckett, W. Thirteen years’ experience in fertility preservation for cancer patients after in vitro fertilization and in vitro maturation treatments. J Assist Reprod Genet, 2018 March;2(97):1–10.Google Scholar
Revel, A, Koler, M, Simon, A et al. Oocyte collection during cryopreservation of the ovarian cortex. Fertil Steril, 2003;79:1237–1239.Google Scholar
Prasath, EB, Chan, ML, Wong, WH et al. First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Hum Reprod, 2014;29:276–278.Google Scholar
Uzelac, PS, Delaney, AA, Christensen, GL et al. Live birth following in vitro maturation of oocytes retrieved from extracorporeal ovarian tissue aspiration and embryo cryopreservation for 5 years. Fertil Steril, 2015;104:1258–1260.Google Scholar
Donnez, J, Dolmans, M-M. Fertility preservation in women. N Engl J Med, 2017 October 26;377(17):1657–1665.Google Scholar
Segers, I, Mateizel, I, Van Moer, E et al. In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe. J Assist Reprod Genet, 2015;32:1221–1231.Google Scholar
Rosendahl, M, Greve, T, Andersen, CY. The safety of transplanting cryo-preserved ovarian tissue in cancer patients: a review of the literature. J Assist Reprod Genet, 2013;30:11–24.Google Scholar
Anderson, RA, McLaughlin, M, Wallace, WHB et al. The immature human ovary shows loss of abnormal follicles and increasing follicle developmental competence through childhood and adolescence. Hum Reprod, 2014;29:97–106.Google Scholar
Demeestere, I, Simon, P, Dedeken, L et al. Live birth after autograft of ovarian tissue cryopreserved during childhood. Hum Reprod, 2015;30:2107–2109.Google Scholar
Rose, BI. Approaches to oocyte retrieval for advanced reproductive technology cycles planning to utilize in vitro maturation: a review of the many choices to be made. J Assist Reprod Genet, 2014;31:1409–1419.Google Scholar
Huang, JY, Buckett, WM, Gilbert, L Tan SL, Chian RC, Retrieval of immature oocytes followed by in vitro maturation and vitrification: A case report on a new strategy of fertility preservation in women with borderline ovarian malignancy. Gynecol Oncol, 2007;105:542–544.Google Scholar
Luyckx, V, Dolmans, MM, Vanacker, J et al. A new step toward the artificial ovary: survival and proliferation of isolated murine follicles after autologous transplantation in a fibrin scaffold. Fertil Steril, 2014;101:1149–1156.Google Scholar
Xu, M, Barrett, SL, West-Farrell, E et al. In vitro grown human ovarian follicles from cancer patients support oocyte growth. Hum Reprod, 2009;24:2531–2540.Google Scholar
Telfer, EE, Zelinski, MB. Ovarian follicle culture: advances and challenges for human and nonhuman primates. Fertil Steril, 2013;99:1523–1533.CrossRefGoogle ScholarPubMed
Garcia-Velasco, JA, Domingo, J, Cobo, A et al. Five years’ experience using oocyte vitrification to preserve fertility for medical and non-medical indications. Fertil Steril, 2013;99:1994–1999.Google Scholar
Johnson, RH, Chien, FL, Bleyer, A. Incidence of breast cancer with distant involvement among women in the United States, 1976 to 2009. Jama, 2013;309(8):800–805. DOI:10.1001/jama.2013.776Google Scholar
Merlo, DF, Ceppi, M, Filiberti, R et al. Breast cancer incidence trends in European women aged 20–39 years at diagnosis. Breast Cancer Res Treat, 2012;134(1):363–370.Google Scholar
Peccatori, FA, Azim, HA, Orecchia, R, et al. Cancer, pregnancy and fertility: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology: Official Journal of the European Society for Medical Oncology / ESMO, 2013;Vol. 24(Suppl 6):vi160–vi170.Google Scholar
Gilchrist, R, Rizk BRMB, Falcone T. Current status and future trends of the clinical practice of human oocyte in vitro maturation. In Gardner D, Smitz JEJ, Thompson JG (eds.) Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice. Cambridge: Cambridge University Press. 2011, 186–198.Google Scholar
Sinclair, KD, Young, LE, Wilmut, I et al. In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men. Hum Reprod, 2000;5:68–86.Google Scholar
Kuhtz, J, Romero, S, De Vos, M et al. Human in vitro oocyte maturation is not associated with increased imprinting error rates at LIT1, SNRPN, PEG3 and GTL2. Hum Reprod, 2014;29:1995–2005.CrossRefGoogle Scholar
Spits, C, Guzman, L, Mertzanidou, A et al. Chromosome constitution of human embryos generated after in vitro maturation including 3-isobutyl-1-methylxanthine in the oocyte collection medium. Hum Reprod, 2015;30:653–663.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×