Childhood Leukemias

doi:10.1017/CBO9780511471001

Childhood Leukemias

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Childhood leukemias represent nearly one third of all cancers in children and present a unique challenge to oncologists, pediatricians, hematologists, and other health professionals. Dr Ching-Hon Pui has assembled an expert team of authors to develop the most comprehensive, clinically-oriented, and authoritative reference dedicated to these diseases. Childhood Leukemias moves from the laboratory bench to the patient bedside in four easily-accessible sections. Part one presents an historical overview, whilst part two presents an in-depth review of topics needed to understand the pathobiology of leukemia. Part three builds upon this scientific foundation by explaining practical approaches to clinical diagnosis, evaluation, and treatment, and part four outlines major clinical complications which may arise during and after treatment, along with chapters on supportive care, psychosocial issues, and nursing. Fully referenced and up-to-date, Childhood Leukemias is an absolute 'must-have' for any physician or investigator who deals with leukemias in childhood.

'… comprehensively referenced and the indexing is simple to use … informative and relevant … I would commend the book to anyone looking for an up to date and comprehensive reference monograph on childhood leukaemia.'

Source: The Bulletin of The Royal College of Pathologists

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Contents

Frontmatter
pp i-vi
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Contents
pp vii-viii
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List of contributors
pp ix-xiv
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Preface
pp xv-xvi
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Part I - History and general issues
pp 1-2
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1 - Historical perspective
pp 3-20
- By Donald Pinkel, Adjunct Professor Biological Sciences Department, California Polytechnic State University, San Luis Obispo, CA, USA
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2 - Diagnosis and classification
pp 21-47
- By Mihaela Onciu, Assistant Member Department of Pathology, Ching-Hon Pui, Director Hematology and Special Hematology Laboratories
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3 - Epidemiology and etiology
pp 48-66
- By Logan G. Spector, Assistant Professor, Division of Pediatric Epidemiology & Clinical Research, Julie A. Ross, Professor, Division of Pediatric Epidemiology & Clinical Research, Leslie L. Robison, Professor, Division of Pediatric Epidemiology & Clinical Research, Smita Bhatia, Director Epidemiology and Outcomes Research, Division of Pediatrics, City of Hope National Medical Center, Duarte, CA, USA
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Part II - Cell biology and pathobiology
pp 67-68
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4 - Anatomy and physiology of hematopoiesis
pp 69-105
- By Connie J. Eaves, Deputy Director Terry Fox Laboratory, Vancouver, British Columbia, Canada, Allen C. Eaves, Director Terry Fox Laboratory, Vancouver, British Columbia, Canada
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5 - Hematopoietic growth factors
pp 106-124
- By James N. Ihle, Investigator, Howard Hughes Medical Institute, Member and Chair, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA
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6 - Signal transduction in the regulation of hematopoiesis
pp 125-149
- By James N. Ihle, Investigator Howard Hughes Medical Institute, Member and Chair, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA
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7 - Immunophenotyping
pp 150-209
- By Fred G. Behm, Associate Member and Vice Chair, Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA
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8 - Immunoglobulin and T-cell receptor gene rearrangements
pp 210-234
- By Jacques J. M. van Dongen, Professor, Department of Immunology, Erasmus University Rotterdam, Rotterdam, the Netherlands, Anton W. Langerak, Department of Immunology, Erasmus University Rotterdam, Rotterdam, the Netherlands
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9 - Cytogenetics of acute leukemias
pp 235-271
- By Susana C. Raimondi, Member and Director of Cytogenetics Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA
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10 - Molecular genetics of acute lymphoblastic leukemia
pp 272-297
- By Adolfo A. Ferrando, Assistant Professor of Pathology and Pediatrics Institute for Cancer Genetics, Columbia University, Irving Cancer Research Center, New York, NY, USA, Jeffrey E. Rubnitz, Associate Member, Department of Hematology/Oncology, Director of Fellowship Program, St. Jude Children's Research Hospital, Memphis, TN, USA, A. Thomas Look, Professor of Pediatrics, Harvard Medical School, Vice Chair for Research, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
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11 - Molecular genetics of acute myeloid leukemia
pp 298-338
- By Robert B. Lorsbach, Assistant Member, Department of Pathology St. Jude Children's Research Hospital, St. Jude Children's Research Hospital, Memphis, TN, USA, James R. Downing, Member and Chair, Department of Pathology, Scientific Director, St. Jude Children's Research Hospital, Memphis, TN, USA
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12 - Apoptosis and chemoresistance
pp 339-361
- By Kirsteen H. Maclean, Research Fellow, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA, John L. Cleveland, Member, Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN, USA
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13 - Heritable predispositions to childhood hematologic malignancies
pp 362-388
- By Doan Le, Clinical Assistant Professor, Alberta Children's Hospital, Calgary, Alberta, Canada, Kevin Shannon, Roma and Marvin Auerback Distinguished Professor of Molecular Oncology, Department of Pediatrics, Program Leader, Hematopoietic Malignancies, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA, Beverly J. Lange, Yetta Dietch Novotny Professor in Clinical Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA
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Part III - Evaluation and treatment
pp 389-390
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14 - Pharmacokinetic, pharmacodynamic, and pharmacogenetic considerations
pp 391-413
- By Shinji Kishi, Faculty of Medical Sciences First Department of Internal Medicine, University of Fukui, Fukui, Japan, William E. Evans, Director, St. Jude Children's Research Hospital, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA, Mary V. Relling, Member and Chair, Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA
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15 - Assays and molecular determinants of cellular drug resistance
pp 414-438
- By Monique L. den Boer, Associate Professor, Molecular Pediatric Oncology Head, Research Laboratory Pediatric Oncology, Erasmus MC–Sophia Children's Hospital, University Medical Center Rotterdam, Department of Pediatric Oncology and Hematology, Rotterdam, the Netherlands, Rob Pieters, Professor and Head, Department of Pediatric Oncology and Hematology, Erasmus MC–Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands
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16 - Acute lymphoblastic leukemia
pp 439-472
- By Ching-Hon Pui, Member and Director, Leukemia/Lymphoma Division, St. Jude Children's Research Hospital, American Cancer Society–F. M. Kirby Clinical Research Professor, Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
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17 - Relapsed acute lymphoblastic leukemia
pp 473-486
- By Günter Henze, Professor and Director, Pediatric Oncology/Hematology, Charité-Campus Virchow Klinikum, Augustenburger Platz, Berlin, Germany, Arend von Stackelberg, Pediatric Oncology/Hematology, Charité-Campus Virchow Klinikum, Berlin, Germany
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18 - B-cell acute lymphoblastic leukemia and Burkitt lymphoma
pp 487-498
- By John T. Sandlund, Member, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA, Ian T. Magrath, Professor of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD
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19 - Acute myeloid leukemia
pp 499-539
- By Jeffrey E. Rubnitz, Associate Member, Department of Hematology/Oncology, Director of Fellowship Program, St. Jude Children's Research Hospital, Memphis, TN, USA, Bassem I. Razzouk, Associate Member, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA, Raul C. Ribeiro, Member, Department of Hematology/Oncology, Director, International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN, USA
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20 - Relapsed acute myeloid leukemia
pp 540-547
- By Ursula Creutzig, Professor, Pediatric Hematology/Oncology, University Children's Hospital Münster, Münster, Germany
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21 - Myelodysplastic syndrome
pp 548-570
- By Henrik Hasle, Associate Professor, Department of Pediatrics, Skejby Hospital, Aarhus University, Aarhus, Denmark
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22 - Chronic myeloproliferative disorders
pp 571-598
- By Charlotte M. Niemeyer, Professor of Pediatrics Department of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, University of Freiburg, Freiburg, Germany, Franco Locatelli, Professor of Pediatrics, Pediatric Hematology and Oncology, IRCCS Policlinico San Matteo, Pavia, Italy
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23 - Hematopoietic stem cell transplantation
pp 599-624
- By Rupert Handgretinger, Director Bone Marrow Transplantation, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA, Victoria Turner, Director, HLA Laboratory, Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA, Raymond Barfield, Assistant Member, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA
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