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Chapter 10 - Prognosis

Published online by Cambridge University Press:  05 May 2016

Christopher M. Filley
University of Colorado School of Medicine
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White Matter Dementia , pp. 135 - 141
Publisher: Cambridge University Press
Print publication year: 2016

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Adams, RD, Kubik, CS. Subacute degeneration of the brain in pernicious anemia. N Engl J Med 1944; 231: 19.CrossRefGoogle Scholar
Alix, JJ, Domingues, AM. White matter synapses: form, function, and dysfunction. Neurology 2011; 76: 397404.CrossRefGoogle ScholarPubMed
Allen, JS, Bruss, J, Damasio, H. The aging brain: the cognitive reserve hypothesis and hominid evolution. Am J Hum Biol 2005; 17: 673689.CrossRefGoogle ScholarPubMed
Amato, MP, Zipoli, V, Portaccio, E. Multiple sclerosis–related cognitive changes: a review of cross-sectional and longitudinal studies. J Neurol Sci 2006; 245: 4146.CrossRefGoogle ScholarPubMed
Bartzokis, G, Lu, PH, Tingus, K, et al. Lifespan trajectory of myelin integrity and maximum motor speed. Neurobiol Aging 2010; 31: 15541562.CrossRefGoogle ScholarPubMed
Bengtsson, SL, Nagy, Z, Skare, S, et al. Extensive piano practicing has regionally specific effects on white matter development. Nat Neurosci 2005; 8: 11481150.CrossRefGoogle ScholarPubMed
Boulanger, JJ, Messier, C. From precursors to myelinating oligodendrocytes: contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain. Neuroscience 2014; 269: 343366.CrossRefGoogle ScholarPubMed
Brown, J, Cooper-Kuhn, CM, Kemperman, G, et al. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci 2003; 17: 20422046.CrossRefGoogle Scholar
Caplan, LR. Binswanger’s disease – revisited. Neurology 1995; 45: 626633.CrossRefGoogle ScholarPubMed
Chen, J, Venkat, P, Zacharek, A, Chopp, M. Neurorestorative therapy for stroke. Front Hum Neurosci 2014; 8: 382.CrossRefGoogle ScholarPubMed
Chen, S, Tanaka, S, Giannini, C, et al. Gliomatosis cerebri: clinical characteristics, management, and outcomes. J Neurooncol 2013; 112: 267275.CrossRefGoogle Scholar
Cumming, TB, Marshall, RS, Lazar, RM. Stroke, cognitive deficits, and rehabilitation: still an incomplete picture. Int J Stroke 2013; 8: 3845.CrossRefGoogle ScholarPubMed
Daselaar, SM, Iyengar, V, Davis, SW, et al. Less wiring, more firing: low-performing older adults compensate for impaired white matter with greater neural activity. Cereb Cortex 2015; 25: 983990.CrossRefGoogle ScholarPubMed
DeKosky, ST, Scheff, SW. Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity. Ann Neurol 1990; 27: 457464.CrossRefGoogle ScholarPubMed
Dikmen, SS, Machamer, JE, Powell, JM, Temkin, NR. Outcome 3 to 5 years after moderate to severe traumatic brain injury. Arch Phys Med Rehabil 2003; 84: 14491457.CrossRefGoogle Scholar
Dingwall, KM, Maruff, P, Fredrickson, A, Cairney, S. Cognitive recovery during and after treatment for volatile solvent abuse. Drug Alcohol Depend 2011; 118: 180185.CrossRefGoogle ScholarPubMed
Dufouil, C, Alperovitch, A, Tzourio, C. Influence of education on the relationship between white matter lesions and cognition. Neurology 2003; 60: 831836.CrossRefGoogle ScholarPubMed
Farinpour, R, Miller, EN, Satz, P, et al. Psychosocial risk factors of HIV morbidity and mortality: findings from the Multicenter AIDS Cohort Study (MACS). J Clin Exp Neuropsychol 2003; 25: 654670.CrossRefGoogle Scholar
Fields, RD. Neuroscience. Change in the brain’s white matter. Science 2010; 330: 768769.CrossRefGoogle Scholar
Filley, CM. The behavioral neurology of white matter. 2nd ed. New York: Oxford University Press, 2012.CrossRefGoogle ScholarPubMed
Filley, CM, Cullum, CM. Education and cognitive function in Alzheimer’s disease. Neuropsychiatry Neuropsychol Behav Neurol 1997; 10: 4851.Google ScholarPubMed
Filley, CM, Kleinschmidt-DeMasters, BK. Toxic leukoencephalopathy. N Engl J Med. 2001; 345: 425432.CrossRefGoogle ScholarPubMed
Filley, CM, Halliday, W, Kleinschmidt-DeMasters, BK. The effects of toluene on the central nervous system. J Neuropathol Exp Neurol 2004; 63: 112.CrossRefGoogle ScholarPubMed
Filley, CM, Kozora, E, Brown, MS, et al. White matter microstructure and cognition in non-neuropsychiatric systemic lupus erythematosus. Cogn Behav Neurol 2009; 22: 3844.CrossRefGoogle ScholarPubMed
Gouw, AA, Seewann, A, van der Flier, WM, et al. Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J Neurol Neurosurg Psychiatry 2011; 82: 126135.CrossRefGoogle ScholarPubMed
Greenough, WT, Bailey, CH. The anatomy of a memory: convergence of results across a diversity of tests. Trends Neurosci 1988; 11: 142147.CrossRefGoogle Scholar
Henninger, N, Izzy, S, Carandang, R, et al. Severe leukoaraiosis portends a poor outcome after traumatic brain injury. Neurocrit Care 2014; 21: 483495.CrossRefGoogle ScholarPubMed
Herting, MM, Colby, JB, Sowell, ER, Nagel, BJ. White matter connectivity and aerobic fitness in male adolescents. Dev Cogn Neurosci 2014; 7: 6575.CrossRefGoogle ScholarPubMed
Hofstetter, S, Tavor, I, Tzur Moryosef, S, Assaf, Y. Short-term learning induces white matter plasticity in the fornix. J Neurosci 2013; 33: 1284412850.CrossRefGoogle ScholarPubMed
Johansson, BB. Current trends in stroke rehabilitation: a review with focus on brain plasticity. Acta Neurol Scand 2011; 123: 147159.CrossRefGoogle ScholarPubMed
Katzman, R, Terry, R, DeTeresa, R, et al. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 1988; 23: 138144.CrossRefGoogle ScholarPubMed
Kesler, SR, Adams, HF, Blasey, CM, et al. Premorbid intellectual functioning, education, and brain size in traumatic brain injury: an investigation of the cognitive reserve hypothesis. Appl Neuropsychol 2003; 10: 153162.CrossRefGoogle Scholar
Kozora, E, Hanly, JG, Lapteva, L, Filley, CM. Cognitive dysfunction in systemic lupus erythematosus: past, present, and future. Arthritis Rheum 2008; 58: 32863298.CrossRefGoogle ScholarPubMed
Kozora, E, Filley, CM. Cognitive dysfunction and white matter abnormalities in systemic lupus erythematosus. J Int Neuropsychol Soc 2011; 17: 18.CrossRefGoogle ScholarPubMed
Langdon, DW. Cognition in multiple sclerosis. Curr Opin Neurol 2011; 24: 244249.CrossRefGoogle ScholarPubMed
Li, P, Legault, J, Litcofsky, KA. Neuroplasticity as a function of second language learning: anatomical changes in the human brain. Cortex 2014; 58: 301324.CrossRefGoogle ScholarPubMed
Luk, G, Bialystok, E, Craik, FI, Grady, CL. Lifelong bilingualism maintains white matter integrity in older adults. J Neurosci 2011; 31: 1680816813.CrossRefGoogle Scholar
Majewska, AK, Sur, M. Plasticity and specificity of cortical processing networks. Trends Neurosci 2006; 29: 323329.CrossRefGoogle ScholarPubMed
Medana, IM, Esiri, MM. Axonal damage: a key predictor of outcome in human CNS diseases. Brain 2003; 26: 515530.CrossRefGoogle Scholar
Miles, L, DeGrauw, TJ, Dinopoulos, A, et al. Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature review. Pediatr Dev Pathol 2009; 12: 180186.CrossRefGoogle ScholarPubMed
Moore, E, Schaefer, RS, Bastin, ME, et al. Can musical training influence brain connectivity? Evidence from diffusion tensor MRI. Brain Sci 2014; 4: 405427.CrossRefGoogle ScholarPubMed
Nitkunan, A, Charlton, RA, McIntyre, DJ, et al. Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease. Magn Reson Med 2008; 59: 528534.CrossRefGoogle Scholar
Orchard, PJ, Tolar, J. Transplant outcomes in leukodystrophies. Semin Hematol 2010; 47: 7078.CrossRefGoogle ScholarPubMed
Petrosini, L, De Bartolo, P, Foti, F, et al. On whether the environmental enrichment may provide cognitive and brain reserves. Brain Res Rev 2009; 61: 221239.CrossRefGoogle Scholar
Rimkus, C de M, Andrade, CS, Leite, C da C, et al. Toxic leukoencephalopathies, including drug, medication, environmental, and radiation-induced encephalopathic syndromes. Semin Ultrasound CT MR 2014; 35: 97117.CrossRefGoogle Scholar
Satz, P. Brain reserve capacity on symptom onset after brain injury: a formulation and review of evidence for threshold theory. Neuropsychology 1993; 7: 273295.CrossRefGoogle Scholar
Schlaug, G, Marchina, S, Norton, A. Evidence for plasticity in white-matter tracts of patients with chronic Broca’s aphasia undergoing intense intonation-based speech therapy. Ann N Y Acad Sci 2009; 1169: 385394.CrossRefGoogle ScholarPubMed
Schofield, PW, Logroscino, G, Andrews, HF, et al. An association between head circumference and Alzheimer’s disease in a population-based study of aging and dementia. Neurology 1997; 49: 3037.CrossRefGoogle Scholar
Sharma, N, Classen, J, Cohen, LG. Neural plasticity and its contribution to functional recovery. Handb Clin Neurol 2013; 110: 312.CrossRefGoogle ScholarPubMed
Sibbitt, WL Jr, Brooks, WM, Kornfeld, M, et al. Magnetic resonance imaging and brain histopathology in neuropsychiatric systemic lupus erythematosus. Semin Arthritis Rheum 2010; 40: 3252.CrossRefGoogle ScholarPubMed
Simon, JH. MRI outcomes in the diagnosis and disease course of multiple sclerosis. Handb Clin Neurol 2014; 122: 405425.CrossRefGoogle ScholarPubMed
Smith, DH, Meaney, DF, Shull, WH. Diffuse axonal injury in head trauma. J Head Trauma Rehabil 2003; 18: 307316.CrossRefGoogle ScholarPubMed
Stern, Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002; 8: 448460.CrossRefGoogle ScholarPubMed
Stern, Y. Cognitive reserve. Neuropsychologia 2009; 47: 20152028.CrossRefGoogle Scholar
Stern, Y. Cognitive reserve in ageing and Alzheimer’s disease. Lancet Neurol 2012; 11: 10061012.CrossRefGoogle ScholarPubMed
Sumowski, JF, Chiaravalloti, N, DeLuca, J. Cognitive reserve protects against cognitive dysfunction in multiple sclerosis. J Clin Exp Neuropsychol 2009; 31: 913926.CrossRefGoogle Scholar
Sumowski, JF, Wylie, GR, Deluca, J, Chiaravalloti, N. Intellectual enrichment is linked to cerebral efficiency in multiple sclerosis: functional magnetic resonance imaging evidence for cognitive reserve. Brain 2010; 133: 362374.CrossRefGoogle Scholar
Sumowski, JF, Rocca, MA, Leavitt, VM, et al. Brain reserve and cognitive reserve protect against cognitive decline over 4.5 years in MS. Neurology 2014; 82: 17761783.CrossRefGoogle ScholarPubMed
Symonds, CP. Mental disorder following head injury (Section of Psychiatry). Proc R Soc Med 1937; 30: 10811094.Google Scholar
Trapp, BD, Peterson, J, Ransohoff, RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998; 338: 278285.CrossRefGoogle ScholarPubMed
Tseng, BY, Gundapuneedi, T, Khan, MA, et al. White matter integrity in physically fit older adults. Neuroimage 2013; 82: 510516.CrossRefGoogle ScholarPubMed
Tullberg, M, Ziegelitz, D, Ribbelin, S, Ekholm, S. White matter diffusion is higher in Binswanger Disease than in idiopathic normal pressure hydrocephalus. Acta Neurol Scand 2009; 120: 226234.CrossRefGoogle ScholarPubMed
Wake, H, Lee, PR, Fields, RD. Control of local protein synthesis and initial events in myelination by action potentials. Science 2011; 333: 16471651.CrossRefGoogle ScholarPubMed
Ward, NS, Frackowiak, RS. Towards a new mapping of brain cortex function. Cerebrovasc Dis 2004; 17 Suppl 3: 3538.CrossRefGoogle ScholarPubMed
Zatorre, RJ, Fields, RD, Johansen-Berg, H. Plasticity in gray and white: neuroimaging changes in brain structure during learning. Nat Neurosci 2012; 15: 528536.CrossRefGoogle ScholarPubMed
Zhang, M, Katzman, R, Salmon, D, et al. The prevalence of dementia and Alzheimer’s disease in Shanghai, China: impact of age, gender and education. Ann Neurol 1990; 27: 428437.CrossRefGoogle Scholar

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  • Prognosis
  • Christopher M. Filley
  • Book: White Matter Dementia
  • Online publication: 05 May 2016
  • Chapter DOI:
Available formats

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  • Prognosis
  • Christopher M. Filley
  • Book: White Matter Dementia
  • Online publication: 05 May 2016
  • Chapter DOI:
Available formats

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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Prognosis
  • Christopher M. Filley
  • Book: White Matter Dementia
  • Online publication: 05 May 2016
  • Chapter DOI:
Available formats