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Chapter 8 - Strokes in Persons Infected with HIV

from Section 1 - Infectious Conditions

Published online by Cambridge University Press:  15 June 2018

By
Kathleen Bateman  and
Alan Bryer
Edited by
Louis Caplan  and
José Biller
Louis Caplan
Affiliation:
Beth Israel-Deaconess Medical Center, Boston
José Biller
Affiliation:
Loyola University Stritch School of Medicine, Chicago
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Uncommon Causes of Stroke , pp. 52 - 62
Publisher: Cambridge University Press
Print publication year: 2018

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References

Abuaf, N., Laperche, S., Rajoely, B., et al. 1997. Auto antibodies to phospholipid and to the coagulation proteins in AIDS. Thromb Haemost, 77, 856–61.Google Scholar
Ake, J. A., Erikson, J. C., and Lowry, K. J. 2006. Cerebral aneurysmal arteriopathy associated with HIV infection in an adult. Clin Infect Dis, 43, e46–50.Google Scholar
Allie, S., Stanley, A., Bryer, A., Meiring, M., and Combrinck, M. I. 2015. High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV-infected patients. Int J Stroke, 10, 1294–6.CrossRefGoogle ScholarPubMed
Anders, K. H., Guerra, W. F., Tomiyasu, U., Verity, M. A., and Vinters, H. V. 1986. The neuropathology of AIDS: UCLA experience and review. Am J Pathol, 124, 537–58.Google Scholar
Benjamin, L. A., Corbett, E. L., Connor, M.D., et al. 2016. HIV, antiretroviral treatment, hypertension and stroke in Malawian adults: A case-control study. Neurology, 86, 1–10.CrossRefGoogle ScholarPubMed
Berger, J. R. 2004. AIDS and stroke risk. Lancet Neurol, 3, 206–7.Google Scholar
Berger, J. R., Harris, J. O., Gregarios, J., and Norenberg, M. 1990. Cerebrovascular disease in AIDS: A case control study. AIDS, 4, 239–44.Google Scholar
Bissuel, F., Berruyer, M., and Causse, X. 1992. Acquired protein S deficiency: Correlation with advanced disease in HIV-1 infected patients. J Acquir Immune Defic Syndr, 5, 484–9.Google Scholar
Budka, H. 1989. Human immunodeficiency virus (HIV)-induced disease of the central nervous system: Pathology and implications for pathogenesis. Acta Neuropathol, 77, 225–36.Google Scholar
Budka, H., Costanzi, G., and Cristina, S. 1987. Brain pathology induced by infection with the human immunodeficiency virus (HIV): A histological, immunocytochemical and electron microscopical study of 100 autopsy cases. Acta Neuropathol (Berlin), 75, 185–98.Google Scholar
Burkholder, G. A., Tamhane, A. R., Salinas, J. L., et al. 2012. Underutilization of aspirin for primary prevention of cardiovascular disease among HIV-infected patients. Clinical Infectious Diseases, 55, 11, 1550–7.Google Scholar
Calabrese, L. H. 1991. Vasculitis and infection with the human immunodeficiency virus. Rheum Dis Clin North Am, 17, 131–47.Google Scholar
Casado Naranjo, I., Toledo Santos, J. A., and Antolin Rodriguez, M. A. 1992. Ischemic stroke as the sole manifestation of human immunodeficiency virus infection. Stroke, 23, 117–8.Google Scholar
Chetty, R. 2005. Vasculitides associated with HIV infection. J Clin Pathol, 54, 275–8.Google Scholar
Chetty, R., Batitang, S., and Nair, R. 2000. Large artery vasculopathy in HIV positive patients. Another vasculitic enigma. Hum Pathol, 31, 374–9.Google Scholar
Choi, A. I., Vittinghoff, E., Deeks, S. G., et al. 2011. Cardiovascular risks associated with abacavir and tenofovir exposure in HIV-infected persons. AIDS 25, 1289–98.Google Scholar
Chow, F. C., Regan, S., Feske, S., et al. 2012. Comparison of ischemic stroke incidence in HIV-infected and non-HIV-infected patients in a US health care system. J Acquir Immune Defic Syndr, 60(4), 351–8.Google Scholar
Cole, J. W., Pinto, A. N., Hebel, J. R., et al. 2004. Acquired immunodeficiency syndrome and the risk of stroke. Stroke, 35, 51–6.CrossRefGoogle ScholarPubMed
Cruciani, M., Zanichellib, V., Serpellonia, G., et al. 2011. Abacavir use and cardiovascular disease events: A meta-analysis of published and unpublished data. AIDS 25, 1993–2004.CrossRefGoogle ScholarPubMed
Connor, M. D., Lammie, G. A., Bell, J. A., et al. 2000. Cerebral infarction in adult AIDS patients. Observations from the Edinburgh HIV autopsy cohort. Stroke, 31, 2117–26.Google Scholar
Dubrovsky, T., Curless, R., Scott, G., et al. 1998. Cerebral aneurysmal arteriopathy in childhood AIDS. Neurology, 51, 560–5.Google Scholar
Engstroom, J. W., Lowenstein, D. H., and Bredesen, D. E. 1989. Cerebral infarction and transient neurological deficits associated with acquired immune deficiency syndrome. AmJ Med, 86, 528–32.Google Scholar
Erbe, M., Rickerts, V., and Bauersachs, R. M. 2003. Acquired protein C and protein S deficiency in HIV infected patients. Clin Appl Thromb Haemost, 9, 325–31.Google Scholar
Evers, S., Nabavi, D., Ratiman, A., et al. 2003. Ischemic cerebrovascular events in HIV infection, a cohort study. Cerebrovasc Dis, 15, 199–205.CrossRefGoogle ScholarPubMed
Freiberg, M. S., Chang, C. H., Kuller, L. H., and Skanderson, M. 2013. HIV Infection and the risk of acute myocardial infarction. JAMA Intern Med, 173, 614–22.Google Scholar
Friis-Møller, N., Thiébaut, R., Reiss, P., et al. for the DAD study group. 2010. Predicting the risk of cardiovascular disease in HIV-infected patients: The data collection on adverse effects of anti-HIV drugs study. Eur J Cardiovasc Prev Rehabil, 17, 5, 491–501.Google Scholar
Gherardi, R., Belec, L., and Mhin, C. 1993. The spectrum of vasculitis in human immunodeficiency virus-infected patients. Arthritis Rheum, 36, 1164–74.Google Scholar
Gillams, A. R., Allen, E., Hrieb, K., et al. 1997. Cerebral infarction in patients with AIDS. AJNR Am J Neuroradiol, 18, 1581–5.Google Scholar
Gisselbrecht, M., Cohen, P., and Lortholary, D. 1998. Human immunodeficiency virus-related vasculitis. Clinical presentation of and therapeutic approach to eight cases. Ann Med Interne (Paris), 149, 398–405.Google Scholar
Goeijenbier, M., van Wissen, M., van de Weg, C., et al. 2012. Viral infections and mechanisms of thrombosis and bleeding. J Med Virol 84, 1680–96.CrossRefGoogle ScholarPubMed
Gutierrez, J. and Ortiz, G. 2011. HIV/AIDS patients with HIV vasculopathy and VZV vasculitis: A case series. Clin Neuroradiol, 21, 145–51.Google Scholar
Hanna, D. B., Post, W. S., Deal, J. A., et al. 2015. HIV infection is associated with progression of subclinical carotid atherosclerosis. Clin Infect Dis 61, 640–50.CrossRefGoogle ScholarPubMed
Hassell, K. L., Kressin, D. C., Neumann, A., Ellison, R., and Marlar, R. A. 1994. Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV infected men. Blood Coagul Fibrinolysis, 5, 455–62.Google Scholar
Ho, D. D., Pomerantz, R. J., and Kaplan, J. C. 1987. Pathogenesis of infection with human immunodeficiency virus. N Engl J Med, 317, 278–86.Google Scholar
Hoffman, M., Berger, J. R., Nath, A., and Rayens, M. 2000. Cerebrovascular disease in young HIV infected black Africans in the Kwa-Zulu Natal Province of South Africa. J Neurovirol, 6, 229–36.Google Scholar
Hsue, P. Y., Lo, J. C., Franklin, A., et al. 2004. Progression of atherosclerosis as assessed by carotid intima–media thickness in patients with HIV infection. Circulation 109, 1603–8.Google Scholar
Joshi, V. V., Pawel, B., Connor, E., et al. 1987. Arteriopathy in children with acquired immune deficiency syndrome. Pediatr Pathol, 7, 261–75.Google ScholarPubMed
Kossorotoff, M., Touzé, E., Godon-Hardy, S., et al. 2006. Cerebral vasculopathy with aneurysm formation in HIV-infected young adults. Neurology, 66, 1121–2.Google Scholar
Kumwenda, J. J., Mateyu, G., Kampondeni, S., et al. 2005. Differential diagnosis of stroke in a setting of high HIV prevalence in Blantyre, Malawi. Stroke, 36, 960–4.Google Scholar
Kuwe, K., Llena, J. F., and Lyman, W. D. 1991. Human immunodeficiency virus-1 infection of the nervous system: An autopsy study of 268 adult, paediatric and foetal brains. Hum Pathol, 22, 700–10.Google Scholar
Lang, W., Miklossy, J., Deruaz, J. P., et al. 1989. Neuropathology of the acquired immune deficiency syndrome (AIDS): A report of 135 consecutive autopsy cases from Switzerland. Acta Neuropathol (Berlin), 77, 379–90.Google Scholar
Libman, B. S., Quismorio, F. P. Jr., and Stimmler, M. M. 1995. Polyarteritis nodosa like vasculitis in human deficiency virus infection. J Rheumatol, 22, 351–5.Google Scholar
Maniker, A. L. and Hunt, C. D. 1996. Cerebral aneurysm in the HIV patient: A report of six cases. Surg Neurol, 46, 49–54.Google Scholar
Marcus, J. L., Leyden, W. A., Chaob, C. R., et al. 2014. HIV infection and incidence of ischemic stroke. AIDS, 28, 1911–1919.CrossRefGoogle ScholarPubMed
Martin, C. M., Matlow, A. G., Chew, E., Sutton, D., and Pruzanski, W. 1989. Hyperviscosity syndrome in a patient with acquired immunodeficiency syndrome. Arch Intern Med, 149, 1435–6.Google Scholar
Martinez-Longoria, C. A., Morales-Aguirre, J. J., Villalobos-Acosta, C. P., Gomez-Barreto, D., and Cashat-Cruz, M. 2004. Occurrence of intracerebral aneurysm in an HIV-infected child: A case report. Pediatr Neurol, 31, 130–2.Google Scholar
Mazzoni, P., Chiriboga, C. A., Millar, W. S., and Rogers, A. 2000. Intracerebral aneurysms in human immunodeficiency virus infection: Case report and literature review. Pediatr Neurol, 23, 252–5.CrossRefGoogle ScholarPubMed
Mizusawa, H., Hirano, A., Llena, J. F., and Shintaku, M. 1988. Cerebrovascular lesions in acquired immune deficiency syndrome (AIDS). Acta Neuropathol, 76, 451–7.Google Scholar
Mochan, A., Modi, M., and Modi, G. 2003. Stroke in black South African HIV positive patients, a prospective analysis. Stroke, 34, 10–15.Google Scholar
Mochan, A., Modi, M., and Modi, G. 2005. Protein S deficiency in HIV associated ischemic stroke: An epiphenomenon of HIV infection. J Neurol Neurosurg Psychiatry, 76, 1455–6.Google Scholar
Nagel, M. A., Cohrs, R. J., Mahalingam, R., et al. 2008. The varicella zoster virus vasculopathies: Clinical, CSF, imaging and virologic features. Neurology, 70, 853.Google Scholar
Nair, R., Chetty, R., Woolgar, J., Naidoo, N. G., and Robbs, J. V. 2001. Spontaneous arteriovenous fistula resulting from HIV arteritis. J Vasc Surg, 33, 186–7.Google Scholar
Nunes, M. L., Pinho, A. P., and Sfoggia, A. 2001. Cerebral aneurysmal dilatation in an infant with perinatally acquired HIV infection and HSV encephalitis. Arq Neuropsiquiatr, 59, 830.Google Scholar
Ovbiagele, B. and Nath, A. 2011. Increasing incidence of ischemic stroke in patients with HIV infection. Neurology, 76, 444.Google Scholar
Patel, V. B., Sacoor, Z., Francis, P., et al. 2005. Ischemic stroke in young HIV positive patients in Kwa-Zulu Natal, South Africa. Neurology, 65, 759–61.Google Scholar
Patsalides, A. D., Wood, L. V., Atac, G. K., et al. 2002. Cerebrovascular disease in HIV-infected pediatric patients. AJR Am J Roentgenol, 179, 999–1003.CrossRefGoogle ScholarPubMed
Petito, C. K., Cho, E. S., Lemann, W., Naria, B. A., and Price, R. W. 1986. Neuropathology of acquired immunodeficiency syndrome (AIDS): An autopsy review. J Neuropathol Exp Neurol, 45, 635–46.CrossRefGoogle ScholarPubMed
Pinto, A. N. 1996. AIDS and cerebrovascular disease. Stroke, 27, 538–43.Google Scholar
Qureshi, A. I. 2005. HIV infection and stroke: If not protein S deficiency then what explains the relationship. J Neurol Neurosurg Psychiatry, 76, 1331.Google Scholar
Qureshi, A. I., Janssen, R. S., Karon, J. M., et al. 1997. Human immunodeficiency virus infection and stroke in young patients. Arch Neurol, 54, 1150–3.Google Scholar
Rabinstein, A. A. 2003. Stroke in HIV-infected patients: A clinical perspective. Cerebrovasc Dis, 15, 37–44.Google Scholar
Rhodes, R. H. 1987. Histopathology of the central nervous system in the acquired immunodeficiency syndrome. Hum Pathol, 18, 636–43.Google Scholar
Rhodes, R. H. and Ward, J. M. 1991. AIDS meningoencephalomyelitis: Pathogenesis and changing neuropathological findings. Pathol Annu, 26, 247–76.Google Scholar
Rubbert, A., Bock, E., Schwab, J., et al. 1994. Anticardiolipin antibodies in HIV infection: Association with cerebral perfusion defects as detected by 99 mTc–HMPAO SPECT. Clin Exp Immunol, 98, 361–8.Google Scholar
Shahbaz, S., Manicardi, M., Guaraldi, G., and Raggi, P. 2015. Cardiovascular disease in human immunodeficiency virus infected patients: A true or perceived risk? World J Cardiol 7, 633–44.Google Scholar
Sico, J. J., Chang, C. C., So-Armah, K., et al. 2015. HIV status and the risk of ischemic stroke among men. Neurology, 84, 1933–40.Google Scholar
Sklar, P., and Masur, H. 2003. HIV infection and cardiovascular disease: Is there really a link? N Engl J Med, 349, 2065–7.Google Scholar
Sorice, M., Griggi, T., and Arceria, P. 1994. Protein S and HIV infection. The role of anticardiolysis and antiprotein S. Thromb Res, 73, 65–175.Google Scholar
Stahl, C. P., Wideman, C. S., and Spira, T. J. 1993. Protein S deficiency in men with long term human immunodeficiency virus infection. Blood, 81, 1801–7.Google Scholar
Statistics, SA. 2014. Mid-year population estimates 2014. See www.statssa.gov.za/publications/P0302/P03022014.pdf.Google Scholar
Sugerman, R. W., Church, J. A., and Goldsmith, J. C. 1996. Acquired protein S deficiency in children infected with human immunodeficiency virus. Pediatr Infect Dis J, 15, 106–11.Google Scholar
Tipping, B., de Villiers, L., Candy, S., and Wainwright, H. 2006. Stroke caused by human immunodeficiency virus-associated intracranial large-vessel aneurysmal vasculopathy. Arch Neurol, 63, 1640–2.Google Scholar
Tipping, B., de Villiers, L., Wainright, H., Candy, S., and Bryer, A. 2007. Stroke in human immunodeficiency virus infections. J Neurol, Neurosurg, and Psychiatr, 78, 1320–4.Google Scholar
Valeriano-Marcet, J., Ravichandran, L., and Kerr, L. D. 1990. HIV associated systemic necrotising vasculitis. J Rheumatol, 17, 1091–3.Google Scholar
Van den Dries, L. W., Gruters, R. A., Hovels-van der Borden, S. B., et al. 2015. Von Willebrand factor is elevated in HIV patients with a history of thrombosis. Front Microbiol, 6, 180.Google Scholar
Walker, R. W., Jusabani, A., Aris, E., et al. 2013. Stroke risk factors in an incident population in urban and rural Tanzania: A prospective, community-based, case control study. Lancet Glob Health, 1, e282–e288.Google Scholar
Worm, S. W., Sabin, C., Weber, R., et al. for the D:A:D Study Group. 2010. Risk of myocardial infarction in patients with HIV infection exposed to specific individual antiretroviral drugs from the 3 major drug classes: The Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study. J Infect Dis, 201, 318–30.Google Scholar
Young, J., Xiao, Y., Moodie, E. M., et al. 2015. Effect of cumulating exposure to abacavir on the risk of cardiovascular disease events in patients from the Swiss HIV cohort study. J Acquir Immune Defic Syndr, 69, 413–21.Google Scholar

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