Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 Testosterone: an overview of biosynthesis, transport, metabolism and non-genomic actions
- 2 The androgen receptor: molecular biology
- 3 Androgen receptor: pathophysiology
- 4 Behavioural correlates of testosterone
- 5 The role of testosterone in spermatogenesis
- 6 Androgens and hair: a biological paradox
- 7 Androgens and bone metabolism
- 8 Testosterone effects on the skeletal muscle
- 9 Androgens and erythropoiesis
- 10 Testosterone and cardiovascular diseases
- 11 Testosterone and erection
- 12 Testosterone and the prostate
- 13 Clinical uses of testosterone in hypogonadism and other conditions
- 14 Pharmacology of testosterone preparations
- 15 Androgen therapy in non-gonadal disease
- 16 Androgens in male senescence
- 17 The pathobiology of androgens in women
- 18 Clinical use of 5α-reductase inhibitors
- 19 Dehydroepiandrosterone (DHEA) and androstenedione
- 20 Selective androgen receptor modulators (SARMs)
- 21 Methodology for measuring testosterone, DHT and SHBG in a clinical setting
- 22 Synthesis and pharmacological profiling of new orally active steroidal androgens
- 23 Hormonal male contraception: the essential role of testosterone
- 24 Abuse of androgens and detection of illegal use
- Subject Index
5 - The role of testosterone in spermatogenesis
Published online by Cambridge University Press: 18 January 2010
- Frontmatter
- Contents
- List of contributors
- Preface
- 1 Testosterone: an overview of biosynthesis, transport, metabolism and non-genomic actions
- 2 The androgen receptor: molecular biology
- 3 Androgen receptor: pathophysiology
- 4 Behavioural correlates of testosterone
- 5 The role of testosterone in spermatogenesis
- 6 Androgens and hair: a biological paradox
- 7 Androgens and bone metabolism
- 8 Testosterone effects on the skeletal muscle
- 9 Androgens and erythropoiesis
- 10 Testosterone and cardiovascular diseases
- 11 Testosterone and erection
- 12 Testosterone and the prostate
- 13 Clinical uses of testosterone in hypogonadism and other conditions
- 14 Pharmacology of testosterone preparations
- 15 Androgen therapy in non-gonadal disease
- 16 Androgens in male senescence
- 17 The pathobiology of androgens in women
- 18 Clinical use of 5α-reductase inhibitors
- 19 Dehydroepiandrosterone (DHEA) and androstenedione
- 20 Selective androgen receptor modulators (SARMs)
- 21 Methodology for measuring testosterone, DHT and SHBG in a clinical setting
- 22 Synthesis and pharmacological profiling of new orally active steroidal androgens
- 23 Hormonal male contraception: the essential role of testosterone
- 24 Abuse of androgens and detection of illegal use
- Subject Index
Summary
Rationale
The endocrine control of testicular function is under investigation for many years. Once it became clear that LH/testosterone and FSH are the key factors in the control of the spermatogenic process, considerable efforts were spent in order to unravel the relative roles of testosterone and FSH for gametogenesis. A variety of experimental approaches was applied covering selective replacement of either hormone in hormone-deficient animal models, selective immunization against LH and FSH or their respective receptors, gene targeting of the reproductive hormones and their receptors, and selective elimination of testosterone-producing Leydig cells by toxicants.
The first edition of this book was published in 1990 followed by an update in 1998. It is interesting that major questions continue to remain an enigma, e.g. the precise mechanism of testosterone and FSH actions and how these hormones cooperate at the testicular level. On the other hand, significant new insights were gained, e.g. that, at least in primates, spermatogonia are the initial target of testosterone and FSH rather than meiotic cells or spermatids and that spermatid release (spermiation) is under endocrine control. Unlike a few years ago, when the relevance of FSH in adult spermatogenesis was questioned, it has become clear that FSH – probably more so than testosterone – is the key regulator of primate spermatogenesis.
The present chapter aims at providing a state-of-the-art review of our current understanding of the role of testosterone in spermatogenesis. Inevitably, we also review the role of FSH in spermatogenesis.
- Type
- Chapter
- Information
- TestosteroneAction, Deficiency, Substitution, pp. 173 - 206Publisher: Cambridge University PressPrint publication year: 2004
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