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11 - Survival Analysis: An Epidemiological Hazard?

Published online by Cambridge University Press:  05 June 2012

David Collier
Affiliation:
University of California, Berkeley
Jasjeet S. Sekhon
Affiliation:
University of California, Berkeley
Philip B. Stark
Affiliation:
University of California, Berkeley
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Summary

Abstract. Proportional-hazards models are frequently used to analyze data from randomized controlled trials. This is a mistake. Randomization does not justify the models, which are rarely informative. Simpler methods work better. This discussion is salient because the misuse of survival analysis has introduced a new hazard in epidemiology: It can lead to serious mistakes in medical treatment. Life tables, Kaplan-Meier curves, and proportional-hazards models, aka “Cox models,” all require strong assumptions, such as stationarity of mortality and independence of competing risks. Where the assumptions fail, the methods also tend to fail. Justifying those assumptions is fraught with difficulty. This is illustrated with examples: the impact of religious feelings on survival and the efficacy of hormone replacement therapy. What are the implications for statistical practice? With observational studies, the models could help disentangle causal relations if the assumptions behind the models can be justified.

In this chapter, I will discuss life tables and Kaplan-Meier estimators, which are similar to life tables. Then I turn to proportional-hazards models, aka “Cox models.” Along the way, I will look at the efficacy of screening for lung cancer, the impact of negative religious feelings on survival, and the efficacy of hormone replacement therapy.

What are the conclusions about statistical practice? Proportional-hazards models are frequently used to analyze data from randomized controlled trials.

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Statistical Models and Causal Inference
A Dialogue with the Social Sciences
, pp. 169 - 192
Publisher: Cambridge University Press
Print publication year: 2009

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