Skip to main content Accessibility help
×
Home
Hostname: page-component-684899dbb8-5dd2w Total loading time: 0.999 Render date: 2022-05-20T21:27:50.910Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true }

Book contents

Chapter 4 - In silicoanalysis strategies and resources for psychiatric genetics research

Published online by Cambridge University Press:  05 October 2012

John I. Nurnberger, Jr
Affiliation:
Indiana University School of Medicine
Wade Berrettini
Affiliation:
University of Pennsylvania School of Medicine
Get access

Summary

Abstract

Although a number of strategies for identifying genetic variations that influence common complex neuropsychiatric diseases have been proposed, implemented, and pursued, many of these strategies have not been able to yield compelling insights into disease pathogenesis. The reasons for this are themselves complex, but it is arguable that extending and integrating available strategies to include detailed biological information can only improve their yield. In this review we consider computational methods, databases, and related resources that can help put into perspective the biological and functional significance of genes and genetic variations interrogated in contemporary gene mapping strategies for neuropsychiatric diseases. Computational methods for evaluating the biological significance of genetic variations, as opposed to laboratory assays, are quick and, for the most part, easy to use and are growing in sophistication. We provide a discussion of the limitations of available resources, but ultimately argue that more integrated approaches to the genetic dissection of complex neuropsychiatric conditions are necessary and likely to be the rule rather than the exception in future investigations.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×