Skip to main content Accessibility help
×
Hostname: page-component-84b7d79bbc-5lx2p Total loading time: 0 Render date: 2024-07-28T18:34:14.797Z Has data issue: false hasContentIssue false

28 - Lung

Published online by Cambridge University Press:  23 December 2009

Fergus Macbeth
Affiliation:
Consultant, Clinical Oncologist, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK
Carys Morgan
Affiliation:
Specialist Registrar in Clinical Oncology, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK
Louise Hanna
Affiliation:
Velindre Hospital, Cardiff
Tom Crosby
Affiliation:
Velindre Hospital, Cardiff
Fergus Macbeth
Affiliation:
Velindre Hospital, Cardiff
Get access

Summary

Introduction

Lung cancer has a significant impact on national mortality in the UK, accounting for 6% of all deaths and 22% of deaths from cancer. It has one of the lowest survival outcomes of any cancer with fewer than 25% alive at 1 year and only a 7% 5-year survival. These 5-year figures have changed little over the past 30 years, although there has been an improvement of around 10% in 1-year survival, probably due to more widespread use of palliative therapies.

Over the past century, lung cancer has gone from a rare disease to being the most common cancer in men and the third most common in women, reflecting smoking habits. The direct link with tobacco use was made in the 1950s in the famous epidemiological study by Doll and Hill (1950); and although smoking prevalence in the population has continued to fall over the past five decades, lung cancer remains a major public health issue. At smoking's peak in the 1940s, 82% of men smoked some form of tobacco; this number fell to a population prevalence of 26% in 2002.

There has previously been a somewhat nihilistic view of lung cancer treatment both among health professionals and patients themselves, with referrals often late and only for palliation of symptoms. Significant changes have occurred more recently with the development of lung cancer services in the UK. In particular, multidisciplinary team (MDT) collaboration and rapid-access chest clinics have had an impact on referral patterns.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Arriagada, R., Pignon, J. P., Laplanche, A.et al. (1997). Prophylactic cranial irradiation for small-cell lung cancer. Lancet, 349, 138.CrossRefGoogle ScholarPubMed
Arriagada, R., Bergman, B., Dunant, A.et al. (2004). Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N. Engl. J. Med., 350, 351–60.Google ScholarPubMed
Aupérin, A., Le, Péchoux C., Pignon, J. P.et al. (2006). Meta-Analysis of Cisplatin/carboplatin based Concomitant Chemotherapy in non-small cell Lung Cancer (MAC3-LC) Group. Concomitant radio-chemotherapy based on platin compounds in patients with locally advanced non-small cell lung cancer (non-small-cell lung cancer): a meta-analysis of individual data from 1764 patients. Ann. Oncol. 17, 473–83.CrossRefGoogle ScholarPubMed
Ruysscher, D., Pijls-Johannesma, M., Vansteenkiste, J.et al. (2006). Systematic review and meta-analysis of randomised, controlled trials of the timing of chest radiotherapy in patients with limited-stage, small-cell lung cancer. Ann. Oncol., 17, 543–52.CrossRefGoogle ScholarPubMed
Doll, R. and Hill, A. B. (1950). Smoking and carcinoma of the lung. Preliminary report. B.M.J., 2 (4682), 739–48.CrossRefGoogle ScholarPubMed
Falk, S. J., Girling, D. J., White, R. J.et al. (2002). Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms: randomised controlled trial. B.M.J.. 325, 465–72.CrossRefGoogle ScholarPubMed
Franklin, W. A. (2000). Diagnosis of lung cancer. Pathology of invasive and preinvasive neoplasia. Chest, 117 (4 Suppl. 1), 80S–89S.Google ScholarPubMed
Graham, M. V., Purdy, J. A., Emami, B.et al. (1999). Clinical dose-volume histogram analysis for pneumonitis after three-dimensional treatment for non small cell lung cancer (non-small-cell lung cancer). Int. J. Radiat. Oncol. Biol. Phys., 45, 323–9.CrossRefGoogle Scholar
Hanna, N., Shepherd, F. A., Fossella, F. V.et al. (2004). Randomized phase III trial of pemetrexed versus docetaxel in patients with non small cell lung cancer previously treated with chemotherapy. J.Clin. Oncol., 22, 1589–97.CrossRefGoogle ScholarPubMed
Masaoka, A., Monden, Y., Nakahara, K.et al. (1981). Follow-up study of thymomas with special reference to their clinical stages. Cancer, 48, 2485–92.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Medical Research Council Lung Cancer Working Party. (1992). A Medical Research Council (Medical Research Council) randomised trial of palliative radiotherapy with two fractions or a single fraction in patients with inoperable non-small-cell lung cancer (non-small-cell lung cancer) and poor performance status. Br. J. Cancer, 65, 934–41.CrossRef
Macbeth, F. R., Bolger, J. J., Hopwood, P.et al. (1996). Randomised trial of palliative two-fraction versus more intensive thirteen fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status. Clin. Oncol., 8, 167–75.CrossRefGoogle Scholar
CF, Mountain. (1997). Revisions in the International System for Staging Lung Cancer. Chest, 111, 1710–17.Google Scholar
Non Small Cell Lung Cancer Collaborative Group. (1995). Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. B.M.J., 311, 899–909.CrossRef
Pignon, J. P. and Arriagada, R. (1992). Role of thoracic radiotherapy in limited-stage small-cell lung cancer: quantitative review based on the literature versus meta-analysis based on individual data. J. Clin. Oncol., 10, 1819–20.CrossRefGoogle ScholarPubMed
Pignon, J. P.Tribodet, G. V., Scagliotti, J. et al. (2006). Lung Adjuvant Cisplatin Evaluation (Lung Adjuvant Cisplatin Evaluation): a pooled analysis of five randomized clinical trials including 4584 patients. J. Clin. Oncol., 24, (18 Suppl.), 7008.Google Scholar
Postoperative Radiotherapy Meta-analysis Trialists Group. (1998). Postoperative radiotherapy in non-small cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomised controlled trials. Lancet, 352, 257–63.CrossRef
Pujol, J. L., Carestia, L. and Daurès, J. P. (2000). Is there a case for cisplatin in the treatment of small-cell lung cancer? A meta-analysis of randomised trials of a cisplatin-containing regimen versus a regimen without this alkylating agent. Br. J. Cancer. 83, 8–15.CrossRefGoogle Scholar
Saunders, M., Dische, S., Barrett, A.et al. (1999). Continuous hyperfractionated accelerated radiotherapy (continuous hyperfractionated accelerated radiotherapy) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial. Radiother. Oncol., 52, 137–48.CrossRefGoogle ScholarPubMed
Schiller, J., Harrington, D., Belani, C. P.et al. (2002). Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N. Engl. J. Med., 346, 92–8.CrossRefGoogle ScholarPubMed
Shepherd, F. A., Pereira, Rodriguez J. R., Ciuleanu, T.et al. (2005). Erlotinib in previously treated non small cell lung cancer. N. Engl. J. Med., 353, 123–32.CrossRefGoogle ScholarPubMed
Spiro, S. G., Rudd, R. M., Souhami, R. L.et al. (2004). Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life. Thorax, 59, 828–36.CrossRefGoogle ScholarPubMed
Stout, R., Barber, P. V., Burt, P. A.et al. (2000). Clinical and quality of life outcomes in the first United Kingdom randomised trial of endobronchial brachytherapy (intraluminal therapy) vs. external beam radiotherapy in the palliative treatment of inoperable non-small cell lung cancer. Radiother. Oncol., 56, 323–7.CrossRefGoogle Scholar
Turrisi, A. T. 3rd, Kim, K., Blum, R.et al. (1999). Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N. Engl. J. Med., 340, 265–71.CrossRefGoogle ScholarPubMed
International Union Against Cancer. (2002). tumour nodes metastases Classification of Malignant Tumours, Ed. Sobin, L. H. and Ch., Wittekind, 6th edn. New York: Wiley-Liss, pp. 97–103.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

  • Lung
    • By Fergus Macbeth, Consultant, Clinical Oncologist, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK, Carys Morgan, Specialist Registrar in Clinical Oncology, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK
  • Edited by Louise Hanna, Tom Crosby, Fergus Macbeth
  • Book: Practical Clinical Oncology
  • Online publication: 23 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545375.029
Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

  • Lung
    • By Fergus Macbeth, Consultant, Clinical Oncologist, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK, Carys Morgan, Specialist Registrar in Clinical Oncology, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK
  • Edited by Louise Hanna, Tom Crosby, Fergus Macbeth
  • Book: Practical Clinical Oncology
  • Online publication: 23 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545375.029
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Lung
    • By Fergus Macbeth, Consultant, Clinical Oncologist, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK, Carys Morgan, Specialist Registrar in Clinical Oncology, Velindre Cancer Centre, Velindre Hospital, Whitchurch, Cardiff, UK
  • Edited by Louise Hanna, Tom Crosby, Fergus Macbeth
  • Book: Practical Clinical Oncology
  • Online publication: 23 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511545375.029
Available formats
×