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Chapter 18 - Precursor Lymphoid Neoplasms

from Section IV - Neoplastic Disorders of Bone Marrow

Published online by Cambridge University Press:  25 January 2024

By
Virginia Knez ,
Alexandra E. Kovach ,
Gordana Raca ,
Billie Carstens  and
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Lymphoblastic leukemias/lymphomas constitute a family of malignant lymphoid neoplasms that morphologically and immunophenotypically recapitulate the features of early lymphoid precursors of either B- or T-cell origin [1–4]. The distinction between acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) is arbitrary [4]. The term LBL is used when the disease is confined to a predominant extramedullary mass lesion with no or minimal involvement (<25%) of peripheral blood and bone marrow (BM). The cases with ≥25% blasts in either peripheral blood or BM are staged and treated as ALL [1,4].

ALL and LBL have many characteristics in common. They are morphologically indistinguishable, share similar immunophenotypes, and have overlapping cytogenetic profiles. It is generally believed that the two entities are biologically equivalent, represent a clinical continuum or different stages of the same disease, and are categorized as such by the 2017 World Health Organization (WHO) classification scheme [2–5].

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Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 208 - 226
Publisher: Cambridge University Press
Print publication year: 2024

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