Skip to main content Accessibility help
×
Hostname: page-component-77c89778f8-9q27g Total loading time: 0 Render date: 2024-07-18T01:13:11.934Z Has data issue: false hasContentIssue false

22 - Can one identify preschizophrenia children?

Published online by Cambridge University Press:  04 August 2010

Eugenia Kravariti
Affiliation:
Institute of Psychiatry, King's College, London, UK
Paola Dazzan
Affiliation:
Institute of Psychiatry, King's College, London, UK
Paul Fearon
Affiliation:
Institute of Psychiatry, King's College, London, UK
Robin M. Murray
Affiliation:
Institute of Psychiatry, King's College, London, UK
Matcheri S. Keshavan
Affiliation:
University of Pittsburgh
James L. Kennedy
Affiliation:
Clarke Institute of Psychiatry, Toronto
Robin M. Murray
Affiliation:
Institute of Psychiatry, London
Get access

Summary

Childhood antecedents of schizophrenia may variably reflect integral components of the schizophrenia diathesis, non-specific factors that potentiate this predisposition, or early manifestations of the disorder itself. This chapter explores the nature of the childhood antecedents of schizophrenia. It explores whether children who develop schizophrenia in adulthood are distinguishable from control children. The chapter examines how strong the association between the distinguishing features of preschizophrenia children as a group and the later development of the disorder is. It also explains ways we can identify preschizophrenia children on the basis of these characteristics. The early risk factors that flag the preschizophrenia status are also considered. Particular emphasis is on prospective population-based, high-risk, and follow-back studies. The measures investigated by the high-risk paradigm can aid in identification of truly vulnerable individuals within the high-risk population.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baum, K. M., Walker, E. F. (1995). Childhood behavioral precursors of adult symptom dimensions in schizophrenia. Schizophr Res 16: 111–120CrossRefGoogle Scholar
Bearden, C. E., Rosso, I. M., Hollister, J. M.et al. (2000). A prospective cohort study of childhood behavioral deviance and language abnormalities as predictors of adult schizophrenia. Schizophr Bull 26: 395–410CrossRefGoogle ScholarPubMed
Cannon, T. D., Rosso, I. M., Bearden, C. E., Sanchez, L. E., Hadley, T. (1999). A prospective cohort study of neurodevelopmental processes in the genesis and epigenesis of schizophrenia. Dev Psychopathol 11: 467–485CrossRefGoogle ScholarPubMed
Cannon, T. D., Rosso, I. M., Hollister, J. M.et al. (2000a). A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia. Schizophr Bull 26: 351–366CrossRefGoogle Scholar
Cannon, T. D., Bearden, C. E., Hollister, J. M.et al. (2000b). Childhood cognitive functioning in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull 26: 379–393CrossRefGoogle Scholar
Cannon, M., Caspi, A., Moffitt, T. E.et al. (2002). Evidence for early-childhood, pan-developmental impairment specific to schizophreniform disorder: results from a longitudinal birth cohort. Arch Gen Psychiatry 59: 449–456CrossRefGoogle ScholarPubMed
Cornblatt, B. A., Erlenmeyer-Kimling, L. (1985). Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. J Abnorm Psychol 94: 470–486CrossRefGoogle ScholarPubMed
Cornblatt, B. A., Lenzenweger, M. F., Dworkin, R. H., Erlenmeyer-Kimling, L. (1992). Childhood attentional dysfunctions predict social deficits in unaffected adults at risk for schizophrenia. Br J Psychiatry 18(Suppl.): 59–64Google Scholar
Cornblatt, B. A., Obuchowski, M., Roberts, S., Pollack, S., Erlenmeyer-Kimling, L. (1999). Cognitive and behavioral precursors of schizophrenia. Dev Psychopathol 11: 487–508CrossRefGoogle ScholarPubMed
Crow, T. J., Done, D. J., Sacker, A. (1995). Childhood precursors of psychosis as clues to its evolutionary origins. Eur Arch Psychiatry Clin Neurosci 245: 61–69CrossRefGoogle ScholarPubMed
David, A. S., Malmberg, A., Brandt, L., Allebeck, P., Lewis, G. (1997). I. Q. and risk for schizophrenia: a population-based cohort study. Psychol Med 27: 1311–1323CrossRefGoogle Scholar
Davidson, M., Reichenberg, A., Rabinowitz, J.et al. (1999). Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am J Psychiatry 156: 1328–1335Google ScholarPubMed
Done, D. J., Crow, T. J., Johnstone, E. C., Sacker, A. (1994). Childhood antecedents of schizophrenia and affective illness: social adjustment at ages 7 and 11. Br Med J 309: 699–703CrossRefGoogle ScholarPubMed
Dworkin, R. H., Cornblatt, B. A. (1995). Predicting schizophrenia. Lancet 345: 139–140CrossRefGoogle ScholarPubMed
Erlenmeyer-Kimling, L., Cornblatt, B. A. (1992). A summary of attentional findings in the New York High-Risk Project. J Psychiatr Res 26: 405–426CrossRefGoogle ScholarPubMed
Erlenmeyer-Kimling, L., Rock, D., Roberts, S. A.et al. (2000). Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York High-Risk Project. Am J Psychiatry 157: 1416–1422CrossRefGoogle ScholarPubMed
Fearon, P., Cannon, M., Murray, R. M. (2001). A critique of the idea and science of risk-factor research in schizophrenia. Int J Ment Health 30: 82–90CrossRefGoogle Scholar
Fish, B. (1977). Neurobiologic antecedents of schizophrenia in children. Evidence for an inherited, congenital neurointegrative defect. Arch Gen Psychiatry 34: 1297–1313CrossRefGoogle ScholarPubMed
Fish, B. (1987). Infant predictors of the longitudinal course of schizophrenia development. Schizophr Bull 13: 395–409CrossRefGoogle Scholar
Fish, B., Marcus, J., Hans, S. L., Auerbach, J. G., Perdue, S. (1992). Infants at risk for schizophrenia: sequelae of a genetic neurointegrative defect. A review and replication analysis of pandysmaturation in the Jerusalem infant development study. Arch Gen Psychiatry 49: 221–235CrossRefGoogle ScholarPubMed
Freedman, L. R., Rock, D., Roberts, S. A., Cornblatt, B. A., Erlenmeyer-Kimling, L. (1998). The New York High-Risk Project: attention, anhedonia and social outcome. Schizophr Res 30: 1–9CrossRefGoogle ScholarPubMed
Geddes, J. R., Lawrie, S. M. (1995). Obstetric complications and schizophrenia: a meta-analysis. Br J Psychiatry 167: 786–793CrossRefGoogle ScholarPubMed
Isohanni, I., Jarvelin, M.-R., Nieminen, P.et al. (1998). School performance as a predictor of psychiatric hospitalization in adult life. A 28-year follow-up in the northern finland 1966 birth cohort. Psychol Med 28: 967–974CrossRefGoogle ScholarPubMed
Isohanni, I., Jarvelin, M. R., Jones, P., Jokelainen, J., Isohanni, M. (1999). Can excellent school performance be a precursor of schizophrenia? A 28-year follow-up in the Northern Finland 1966 birth cohort. Acta Psychiatr Scand 100: 17–26CrossRefGoogle ScholarPubMed
Isohanni, M., Jones, P. B., Moilanen, K.et al. (2001). Early developmental milestones in adult schizophrenia and other psychoses. A 31-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophr Res 52: 1–19CrossRefGoogle ScholarPubMed
Jones, P., Done, D. J. (1997). From birth to onset: a developmental perspective of schizophrenia in two national birth cohorts. In Neurodevelopment and Adult Psychopathology, ed. M. S. Keshavan, R. M. Murray. Cambridge, UK: Cambridge University Press, pp. 119–136
Jones, P., Rodgers, B., Murray, R., Marmot, M. (1994). Child developmental risk factors for adult schizophrenia in the British 1946 birth cohort. Lancet 344: 1398–1402CrossRefGoogle ScholarPubMed
Kraepelin, E. (1919). Dementia Praecox and Paraphrenia. Edinburgh: Livingston
Leask, S. J., Done, D. J., Crow, T. J. (2002). Adult psychosis, common childhood infections and neurological soft signs in a national birth cohort. Br J Psychiatry 181: 387–392CrossRefGoogle Scholar
Marcus, J., Hans, S. L., Nagler, S.et al. (1987). Review of the NIMH Israeli Kibbutz-City Study and the Jerusalem Infant Development Study. Schizophr Bull 13: 425–438CrossRefGoogle ScholarPubMed
McGrath, J., Murray, R. M. (1995). Risk factors for schizophrenia: from conception to birth. In Schizophrenia, ed. S. Hirsh, D. Weinberger. Oxford: Blackwell, pp. 187–205
McNeil, T. F. (1995). Perinatal risk factors and schizophrenia: selective review and methodological concerns. Epidemiol Rev 17: 107–112CrossRefGoogle ScholarPubMed
Mirsky, A. F., Ingraham, L. J., Kugelmass, S. (1995). Neuropsychological assessment of attention and its pathology in the Israeli cohort. Schizophr Bull 21: 193–204CrossRefGoogle ScholarPubMed
Murray, R. M. (1994). Neurodevelopmental schizophrenia: the rediscovery of dementia praecox. Br J Psychiatry 165: 6–12Google Scholar
Murray, R. M., Lewis, S. W. (1987). Is schizophrenia a neurodevelopmental disorder?Br Med J (Clin Res Ed) 295: 681–682CrossRefGoogle ScholarPubMed
Olin, S. C., Mednick, S. A. (1996). Risk factors of psychosis: identifying vulnerable populations premorbidly. Schizophr Bull 22: 223–240CrossRefGoogle ScholarPubMed
O'Toole, B. I. (2000). Screening for low prevalence disorders. Aust N Z J Psychiatry 34(Suppl): S39–S46CrossRefGoogle ScholarPubMed
Ott, S. L., Spinelli, S., Rock, D.et al. (1998). The New York High-Risk Project: social and general intelligence in children at risk for schizophrenia. Schizophr Res 31: 1–11CrossRefGoogle ScholarPubMed
Parnas, J., Schulsinger, F., Schulsinger, H., Mednick, S. A., Teasdale, T. W. (1982). Behavioral precursors of schizophrenia spectrum. A prospective study. Arch Gen Psychiatry 39: 658–664CrossRefGoogle ScholarPubMed
Rosso, I. M., Bearden, C. E., Hollister, J. M.et al. (2000). Childhood neuromotor dysfunction in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophr Bull 26: 367–378CrossRefGoogle ScholarPubMed
Os, J., Jones, P. B., Lewis, S., Wadsworth, M., Murray, R. M. (1997). Developmental precursors of affective illness in a general population birth cohort. Arch Gen Psychiatry 54: 625–631Google Scholar
Walker, E., Lewine, R. J. (1990). Prediction of adult-onset schizophrenia from childhood home movies of the patients. Am J Psychiatry 147: 1052–1056Google ScholarPubMed
Walker, E. F., Grimes, K. E., Davis, D. M., Smith, A. J. (1993). Childhood precursors of schizophrenia: facial expressions of emotion. Am J Psychiatry 150: 1654–1660Google ScholarPubMed
Walker, E. F., Savoie, T., Davis, D. (1994). Neuromotor precursors of schizophrenia. Schizophr Bull 20: 441–451CrossRefGoogle ScholarPubMed
Weinberger, D. R. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Arch Gen Psychiatry 44: 660–669CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×