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Keynote Essay 6: Molecular Research Case Study: Developing Novel RNA Interference-based Therapy

from SECTION 3 - MOLECULAR THERAPEUTICS

Published online by Cambridge University Press:  04 June 2019

Patrick Arbuthnot
Affiliation:
MB BCh, BSc (Hons), PhD, is a reader in the Division of Molecular Medicine and Haematology at the Medical School of the University of the Witwatersrand, Johannesburg. He has a research interest in using nucleic acid transfer to develop new approaches to treating viral infections of South African importance.
Marc S Weinberg
Affiliation:
PhD, is a senior lecturer in the Division of Molecular Medicine and Haematology, University of the Witwatersrand, and a member of the Antiviral Gene Therapy Research Unit.
Barry Mendelow
Affiliation:
University of the Witwatersrand, Johannesburg
Michèle Ramsay
Affiliation:
University of the Witwatersrand, Johannesburg
Nanthakumarn Chetty
Affiliation:
University of the Witwatersrand, Johannesburg
Wendy Stevens
Affiliation:
University of the Witwatersrand, Johannesburg
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Summary

THE VALUE OF ACADEMIC RESEARCH

Research can be defined as the process of discovery and creation of new knowledge. A vital role for universities is to carry out research, and success in this activity is a good gauge of the well-being of these academic institutions. All leading universities of the world (such as Harvard, Cambridge and Oxford universities) have a strong commitment to supporting research, and this is the foundation of their good reputations. Research is vital to any society and positive outcomes go way beyond the direct practical application of new discoveries. By nurturing creativity, critical thinking, open-mindedness and enquiry, research has the broad benefits of building a strong democratic ethic in society. Today we refer to the importance of the ‘knowledge based economy’ where societies become more reliant on creation and exploitation of new knowledge to understand and overcome economic and political challenges. An active research community allows countries to benefit directly from new developments of the twenty first century and to participate in developing a knowledge-based economy. The benefits of an active research environment can have both direct and indirect effects on society. Some of these benefits are listed below.

  • Improved training of students. An often under-appreciated role of research is that it is beneficial to teaching in universities. By and large, research activities are supportive of university educational programmes, and teachers who are immersed in active research generally make better instructors. Research leads to more meaningful insight into a subject, and educators pass this benefit on to students through better teaching. High-level training of students that is not based on a foundation of academic research risks becoming stale and outmoded.

  • Promoting innovation for patient care. Insights gained from research on medical challenges contribute significantly to understanding and overcoming patient problems, which collectively makes for better patient management and care.

  • Broadening the knowledge base for the good of humanity. Some of the most significant breakthroughs in technology have come from unlikely research contributions. Research does not always produce immediately obvious practical benefits, and it is often only after several years that the utility of research becomes apparent.

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    Publisher: Wits University Press
    Print publication year: 2008

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    • Keynote Essay 6: Molecular Research Case Study: Developing Novel RNA Interference-based Therapy
      • By Patrick Arbuthnot, MB BCh, BSc (Hons), PhD, is a reader in the Division of Molecular Medicine and Haematology at the Medical School of the University of the Witwatersrand, Johannesburg. He has a research interest in using nucleic acid transfer to develop new approaches to treating viral infections of South African importance., Marc S Weinberg, PhD, is a senior lecturer in the Division of Molecular Medicine and Haematology, University of the Witwatersrand, and a member of the Antiviral Gene Therapy Research Unit.
    • Edited by Barry Mendelow, University of the Witwatersrand, Johannesburg, Michèle Ramsay, University of the Witwatersrand, Johannesburg, Nanthakumarn Chetty, University of the Witwatersrand, Johannesburg, Wendy Stevens, University of the Witwatersrand, Johannesburg
    • Book: Molecular Medicine for Clinicians
    • Online publication: 04 June 2019
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    • Keynote Essay 6: Molecular Research Case Study: Developing Novel RNA Interference-based Therapy
      • By Patrick Arbuthnot, MB BCh, BSc (Hons), PhD, is a reader in the Division of Molecular Medicine and Haematology at the Medical School of the University of the Witwatersrand, Johannesburg. He has a research interest in using nucleic acid transfer to develop new approaches to treating viral infections of South African importance., Marc S Weinberg, PhD, is a senior lecturer in the Division of Molecular Medicine and Haematology, University of the Witwatersrand, and a member of the Antiviral Gene Therapy Research Unit.
    • Edited by Barry Mendelow, University of the Witwatersrand, Johannesburg, Michèle Ramsay, University of the Witwatersrand, Johannesburg, Nanthakumarn Chetty, University of the Witwatersrand, Johannesburg, Wendy Stevens, University of the Witwatersrand, Johannesburg
    • Book: Molecular Medicine for Clinicians
    • Online publication: 04 June 2019
    Available formats
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    Save book to Google Drive

    To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

    • Keynote Essay 6: Molecular Research Case Study: Developing Novel RNA Interference-based Therapy
      • By Patrick Arbuthnot, MB BCh, BSc (Hons), PhD, is a reader in the Division of Molecular Medicine and Haematology at the Medical School of the University of the Witwatersrand, Johannesburg. He has a research interest in using nucleic acid transfer to develop new approaches to treating viral infections of South African importance., Marc S Weinberg, PhD, is a senior lecturer in the Division of Molecular Medicine and Haematology, University of the Witwatersrand, and a member of the Antiviral Gene Therapy Research Unit.
    • Edited by Barry Mendelow, University of the Witwatersrand, Johannesburg, Michèle Ramsay, University of the Witwatersrand, Johannesburg, Nanthakumarn Chetty, University of the Witwatersrand, Johannesburg, Wendy Stevens, University of the Witwatersrand, Johannesburg
    • Book: Molecular Medicine for Clinicians
    • Online publication: 04 June 2019
    Available formats
    ×