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9 - Contrast agents for x-ray and MR imaging

Published online by Cambridge University Press:  01 March 2011

R. Nick Bryan
Affiliation:
University of Pennsylvania
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Summary

Radiographic contrast

In Chapter 5, the basic physics of x-ray imaging was described. To briefly review, the x-rays are generated by the electrons in the x-ray tube striking the anode at high energy. More specifically, the energy of the electrons (in electronvolts, eV) is numerically equal to the kilovoltage applied to the anode. This creates a beam of external x-rays that has a very wide energy spectrum. The x-ray energies cover a range from (theoretically) 0 eV up to a maximum equal to the applied kilovoltage. In practice, because low-energy x-rays are much more rapidly absorbed than those with higher energies, the very lowest x-rays are absorbed in the glass envelope of the x-ray tube. More to the point, x-ray tubes are always operated with an additional metallic layer covering the opening port. This is called the “filter” and is intended further to raise the minimum x-ray energy. Because lower-energy x-rays are also absorbed by the human body more readily than those of higher energy, the absorption of the low-energy rays will contribute ionization dose to the patient's tissues without significantly contributing to image contrast, which is undesirable. Thus the radiologist can vary the so-called “effective energy” of the beam, usually by adjusting the applied kV, or occasionally by adding more metal as filter. The exact technique used depends on various factors, including the thickness of the body part being imaged and the nature of the pathology expected.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2009

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References

Levine, MS, Rubesin, SE, Laufer, I, Herlinger, H. Diagnosis of colorectal neoplasms at double-contrast barium enema examination. Radiology 2000; 216: 11–18.CrossRefGoogle ScholarPubMed
Costa, N. Understanding contrast media. J Infus Nurs 2004; 27: 302–12.CrossRefGoogle ScholarPubMed
Chiechi, MV, Smirniotopoulos, JG, Mena, H. Intracranial hemangiopericytomas: MR and CT features. AJNR Am J Neuroradiol 1996; 17: 1365–71.Google ScholarPubMed
Vosshenrich, R, Fischer, U. Contrast-enhanced MR angiography of abdominal vessels: is there still a role for angiography? Eur Radiol 2002; 12: 218–30.CrossRefGoogle Scholar
Schaefer, PJ, Schaefer, FKW, Mueller-Huelsbeck, S, et al. Value of single-dose contrast-enhanced magnetic resonance angiography versus intraarterial digital subtraction angiography in therapy indications in abdominal and iliac arteries. Cardiovasc Intervent Radiol 2005; 30: 376–82.CrossRefGoogle Scholar
Thomsen, HS. Nephrongenic systemic fibrosis: a serious late adverse effect of gadodiamide. Eur Radiol 2006; 16: 2619–21.CrossRefGoogle Scholar
Wang, YX, Hussain, SM, Krestin, GP. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol 2001; 11: 2319–31.CrossRefGoogle ScholarPubMed
Tanimoto, A, Kuribayashi, S. Application of superparamagnetic iron oxide to imaging of hepatocellular carcinoma. Eur J Radiol 2006; 58: 200–16.CrossRefGoogle ScholarPubMed
Weissleder, R, Elizondo, G, Wittenberg, J, et al. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 1990; 175: 489–93.CrossRefGoogle ScholarPubMed
Harisinghani, MG, Barentsz, J, Hahn, PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 2003; 348: 2491–9.CrossRefGoogle ScholarPubMed
Neuwelt, EA, Varallyay, CG, Manninger, S, et al. The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: a pilot study. Neurosurgery 2007; 60: 601–11.CrossRefGoogle ScholarPubMed
Raman, V, Pathak, AP, Glunde, K, Artemov, D, Bhujwalla, ZM. Magnetic resonance imaging and spectroscopy of transgenic models of cancer. NMR Biomed 2007; 20: 186–99.CrossRefGoogle ScholarPubMed
Daniels, TR, Delgado, T, Helguera, G, Penichet, ML. The transferrin receptor part II: targeted delivery of therapeutic agents into cancer cells. Clin Immunol 2006; 121: 159–76.CrossRefGoogle ScholarPubMed
Hogemann-Savellano, D, Bos, E, Blondet, C, et al. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia 2003; 5: 495–506.CrossRefGoogle ScholarPubMed

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