Book contents
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Chapter 1 Women's Health Initiative Memory Study (WHIMS) program: emerging findings
- Chapter 2 Identifying risk factors for cognitive change in the Women's Health Initiative: a neural networks approach
- Chapter 3 Estrogen therapy – relationship to longevity and prevalent dementia in the oldest-old: the Leisure World Cohort Study and the 90+ Study
- Chapter 4 The critical window hypothesis: hormone exposures and cognitive outcomes after menopause
- Chapter 5 Animal studies that support estrogen effects on cognitive performance and the cholinergic basis of the critical period hypothesis
- Chapter 6 The healthy cell bias of estrogen action through regulating glucose metabolism and mitochondrial function: implications for prevention of Alzheimer's disease
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Section 6 Gonadotropin effects
- Index
- Plate Section
Chapter 1 - Women's Health Initiative Memory Study (WHIMS) program: emerging findings
from Section 1 - Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
Published online by Cambridge University Press: 06 July 2010
Book contents
- Hormones, Cognition and Dementia
- Hormones, Cognition and Dementia
- Copyright page
- Contents
- Contributors
- Preface
- Section 1 Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study
- Chapter 1 Women's Health Initiative Memory Study (WHIMS) program: emerging findings
- Chapter 2 Identifying risk factors for cognitive change in the Women's Health Initiative: a neural networks approach
- Chapter 3 Estrogen therapy – relationship to longevity and prevalent dementia in the oldest-old: the Leisure World Cohort Study and the 90+ Study
- Chapter 4 The critical window hypothesis: hormone exposures and cognitive outcomes after menopause
- Chapter 5 Animal studies that support estrogen effects on cognitive performance and the cholinergic basis of the critical period hypothesis
- Chapter 6 The healthy cell bias of estrogen action through regulating glucose metabolism and mitochondrial function: implications for prevention of Alzheimer's disease
- Section 2 Varieties of estrogenic therapy
- Section 3 Potential modulators and modifiers of estrogenic effects
- Section 4 Possible genetic factors related to hormone treatment effects
- Section 5 Testosterone, estradiol and men, and sex hormone binding globulin
- Section 6 Gonadotropin effects
- Index
- Plate Section
Summary
The landmark women's health initiative memory study (WHIMS) program has had an enormous impact on understanding of how estrogens and estrogen-containing hormone therapy affect cognitive outcomes in postmenopausal women. This chapter focuses on the impact of hormone therapy on cognition in older women. It summarizes the primary findings of the women's health initiative (WHI) on cardiovascular disease. The WHIMS also found a small adverse effect of assignment to hormone therapy on global cognitive function, as measured by modified mini-mental state (3MS) examinations. The Women's Health Initiative Study of cognitive aging (WHISCA) was designed to examine the impact of conjugated equine estrogens (CEE)-based therapy on longitudinal changes of cognitive tests targeting several different domains. The women's health initiative memory study of magnetic resonance imaging (WHIMS-MRI) was designed to contrast neuroradiologic outcomes among women who had been assigned to active versus placebo therapy during the WHIMS trials.
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- Hormones, Cognition and DementiaState of the Art and Emergent Therapeutic Strategies, pp. 1 - 10Publisher: Cambridge University PressPrint publication year: 2009
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