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Chapter 30 - Bacterial Sepsis in the Neonate

from Section 4 - Specific Conditions Associated with Fetal and Neonatal Brain Injury

Published online by Cambridge University Press:  13 December 2017

David K. Stevenson
Affiliation:
Stanford University, California
William E. Benitz
Affiliation:
Stanford University, California
Philip Sunshine
Affiliation:
Stanford University, California
Susan R. Hintz
Affiliation:
Stanford University, California
Maurice L. Druzin
Affiliation:
Stanford University, California
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References

Freedman, RM, Ingram, DL, Gross, I, et al. A half century of neonatal sepsis at Yale: 1928 to 1978. Am J Dis Child 1981; 135: 140–4.CrossRefGoogle ScholarPubMed
Bizzarro, MJ, Dembry, LM, Baltimore, RS, Gallagher, PG. Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis. Pediatrics 2008; 121: 689–96.CrossRefGoogle ScholarPubMed
Bizzarro, MJ, Raskind, C, Baltimore, RS, Gallagher, PG. Seventy-five years of neonatal sepsis at Yale: 1928–2003. Pediatrics 2005; 116: 595602.CrossRefGoogle ScholarPubMed
Bizzarro, MJ, Shabanova, V, Baltimore, RS, et al. Neonatal sepsis 2004–2013: the rise and fall of coagulase-negative staphylococci. J Pediatr 2015; 166: 1193–9.Google Scholar
Gladstone, IM, Ehrenkranz, RA, Edberg, SC, Baltimore, RS. A ten-year review of neonatal sepsis and comparison with the previous fifty-year experience. Pediatr Infect Dis J 1990; 9: 819–25.Google Scholar
Baltimore, RS, Huie, SM, Meek, JI, et al. Early-onset neonatal sepsis in the era of group B streptococcal prevention. Pediatrics 2001; 108: 1094–8.Google Scholar
Chen, KT, Puopolo, KM, Eichenwald, EC, et al. No increase in rates of early-onset neonatal sepsis by antibiotic-resistant group B Streptococcus in the era of intrapartum antibiotic prophylaxis. Am J Obstet Gynecol 2005; 192: 1167–71.Google Scholar
Daley, AJ, Isaacs, D. Ten-year study on the effect of intrapartum antibiotic prophylaxis on early onset group B streptococcal and Escherichia coli neonatal sepsis in Australasia. Pediatr Infect Dis J 2004; 23: 630–4.Google Scholar
Edwards, RK, Jamie, WE, Sterner, D, et al. Intrapartum antibiotic prophylaxis and early-onset neonatal sepsis patterns. Infect Dis Obstet Gynecol 2003; 11: 221–6.CrossRefGoogle ScholarPubMed
Moore, MR, Schrag, SJ, Schuchat, A. Effects of intrapartum antimicrobial prophylaxis for prevention of group-B streptococcal disease on the incidence and ecology of early-onset neonatal sepsis. Lancet Infect Dis 2003; 3: 201–13.CrossRefGoogle ScholarPubMed
Schrag, SJ, Stoll, BJ. Early-onset neonatal sepsis in the era of widespread intrapartum chemoprophylaxis. Pediatr Infect Dis J 2006; 25: 939–40.CrossRefGoogle ScholarPubMed
Baker, CJ, Halsey, NA, Schuchat, A. 1997 AAP guidelines for prevention of early-onset group B streptococcal disease. Pediatrics 1999; 103: 701.Google Scholar
Eichenwald, EC. Perinatally transmitted neonatal bacterial infections. Infect Dis Clin North Am 1997; 11: 223–39.Google Scholar
Hyde, TB, Hilger, TM, Reingold, A, et al. Trends in incidence and antimicrobial resistance of early-onset sepsis: population-based surveillance in San Francisco and Atlanta. Pediatrics 2002; 110: 690–5.Google Scholar
Schrag, S, Schuchat, A. Prevention of neonatal sepsis. Clin Perinatol 2005; 32: 601–15.Google Scholar
Schuchat, A, Zywicki, SS, Dinsmoor, MJ, et al. Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study. Pediatrics 2000; 105: 21–6.Google Scholar
Vesikari, T, Janas, M, Gronroos, P, et al. Neonatal septicaemia. Arch Dis Child 1985; 60: 542–6.Google Scholar
Edwards, MS, Nizet, V, Baker, CJ. Group B streptococcal infections. In Infectious Diseases of the Fetus and Newborn Infant, 6th edn. Philadelphia: Saunders, 2006: 403–64.Google Scholar
Lukacs, SL, Schoendorf, KC. National estimates of newborn sepsis rates in the United States, 1990–2001. Presented at the Annual Meeting of the Society for Pediatric and Perinatal Epidemioloic Research, Salt Lake City, UT, 2004.Google Scholar
Lukacs, SL, Schoendorf, KC, Schuchat, A. Trends in sepsis-related neonatal mortality in the United States, 1985–1998. Pediatr Infect Dis J 2004; 23: 599603.Google Scholar
Schrag, SJ, Hadler, JL, Arnold, KE, et al. Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use. Pediatrics 2006; 118: 570–6.CrossRefGoogle ScholarPubMed
Seale, AC, Blencowe, H, Zaidi, A, et al. Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010. Pediatr Res 2013; 74: 7385.CrossRefGoogle ScholarPubMed
Ganatra, HA, Zaidi, AK. Neonatal infections in the developing world. In Seminars in Perinatology. New York: Elsevier, 2010: 416–25.Google Scholar
Thaver, D, Zaidi, AK. Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatr Infect Dis 2009; 28: S39.Google Scholar
Zaidi, AKM, Darmstadt, GL, Stoll, B. Neonatial infections: a global perspective. In Infectious Disease of the Fetus and Newborn Infant, 8th edn. Philadelphia: Saunders, 2014.Google Scholar
Darmstadt, GL, Saha, SK, Choi, Y, et al. Population-based incidence and etiology of community-acquired neonatal bacteremia in Mirzapur, Bangladesh: an observational study. J Infect Dis 2009; 200: 906–15.CrossRefGoogle ScholarPubMed
Seale, AC, Blencowe, H, Manu, AA, et al. Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, South Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet Infect Dis 2014; 14: 731–41.Google Scholar
Darmstadt, GL, Ahmed, S, Ahmed, ANU, Saha, SK. Mechanism for prevention of infection in preterm neonates by topical emollients: a randomized, controlled clinical trial. Pediatr Infect Dis J 2014; 33: 1124–7.CrossRefGoogle ScholarPubMed
Darmstadt, GL, Saha, SK, Ahmed, S, et al. Effect of topical emollient treatment of preterm neonates in Bangladesh on invasion of pathogens into the bloodstream. Pediatr Res 2007; 61: 588–93.Google Scholar
Arachaisri, T, Ballow, M. Developmental immunology of the newborn. Immunol Allergy Clin North Am 1999; 19: 253–79.Google Scholar
Lewis, D, Wilson, C. Developmental Immunology and Role of the Host Defenses in Neonatal Susceptibility to Infection, 4th edn. Philadelphia: Saunders, 1995.Google Scholar
Georgeson, GD, Szony, BJ, Streitman, K, et al. Natural killer cell cytotoxicity is deficient in newborns with sepsis and recurrent infections. Eur J Pediatr 2001; 160: 478–82.Google Scholar
Wilson, DC, Edgar, JD. Predictors of bacterial infection in neonates. J Pediatr 1997; 130: 166.Google Scholar
Herbst, A, Källén, K. Time between membrane rupture and delivery and septicemia in term neonates. Obstet Gynecol 2007; 110: 612–18.Google Scholar
Gerdes, JS. Diagnosis and management of bacterial infections in the neonate. Pediatr Clin North Am 2004; 51: 939–59.Google Scholar
Chen, KT, Ringer, S, Cohen, AP, Lieberman, E. The role of intrapartum fever in identifying asymptomatic term neonates with early-onset neonatal sepsis. J Perinatol 2002; 22: 653–7.Google Scholar
Schrag, SJ, Zell, ER, Lynfield, R, et al. A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates. N Engl J Med 2002; 347: 233–9.Google Scholar
Towers, CV, Suriano, K, Asrat, T. The capture rate of at-risk term newborns for early-onset group B streptococcal sepsis determined by a risk factor approach. Am J Obstet Gynecol 1999; 181: 1243–9.Google Scholar
Yancey, MK, Duff, P, Kubilis, P, et al. Risk factors for neonatal sepsis. Obstet Gynecol 1996; 87: 188–94.Google Scholar
Glasgow, TS, Young, PC, Wallin, J, et al. Association of intrapartum antibiotic exposure and late-onset serious bacterial infections in infants. Pediatrics 2005; 116: 696702.Google Scholar
Taukobong, HF, Kincaid, MM, Levy, JK, et al. Does addressing gender inequalities and empowering women and girls improve health and development programme outcomes? Health Policy Plan 2016; 10: 14921514.Google Scholar
Lawn, JE, Blencowe, H, Oza, S, et al. Every newborn: progress, priorities, and potential beyond survival. Lancet 2014; 384: 189205.Google Scholar
Darmstadt, GL, Syed, U, Patel, Z, Kabir, N. Review of domiciliary newborn-care practices in Bangladesh. J Health Popul Nutr 2006; 24: 380–93.Google Scholar
Kumar, V, Kumar, A, Ghosh, AK, et al. Enculturating science: community-centric design of behavior change interactions for accelerating health impact. Semin Perinatol 2015; 39: 393415.CrossRefGoogle ScholarPubMed
Kumar, V, Mohanty, S, Kumar, A, et al. Effect of community-based behaviour change management on neonatal mortality in Shivgarh, Uttar Pradesh, India: a cluster-randomised controlled trial. Lancet 2008; 372: 1151–62.Google Scholar
Mullany, LC, Darmstadt, GL, Katz, J, et al. Risk factors for umbilical cord infection among newborns of southern Nepal. Am J Epidemiol 2007; 165: 203–11.Google Scholar
Mullany, LC, Katz, J, Li, YM, et al. Breast-feeding patterns, time to initiation, and mortality risk among newborns in southern Nepal. J Nutrition 2008; 138: 599603.CrossRefGoogle ScholarPubMed
Winch, PJ, Alam, MA, Akther, A, et al. Local understandings of vulnerability and protection during the neonatal period in Sylhet district, Bangladesh: a qualitative study. Lancet 2005; 366: 478–85.Google Scholar
Weston, EJ, Pondo, T, Lewis, MM, et al. The burden of invasive early-onset neonatal sepsis in the United States, 2005–2008. Pediatr Infect Dis J 2011; 30: 937.Google Scholar
Stoll, BJ, Hansen, NI, Sánchez, PJ, et al. Early onset neonatal sepsis: the burden of group B streptococcal and E. coli disease continues. Pediatrics 2011; 127:817–26.Google Scholar
Denniston, S, Riordan, FA. Staphylococcus aureus bacteraemia in children and neonates: a 10 year retrospective review. J Infect 2006; 53: 387–93.CrossRefGoogle ScholarPubMed
Hakim, H, Mylotte, JM, Faden, H. Morbidity and mortality of staphylococcal bacteremia in children. Am J Infect Control 2007; 35: 102–5.Google Scholar
Verani, JR, McGee, L, Schrag, SJ. Prevention of perinatal group B streptococcal disease: Revised guidelines from CDC, 2010. Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, 2010.Google Scholar
Polin, RA, Papile, L-A, Baley, JE, et al. Management of neonates with suspected or proven early-onset bacterial sepsis. Pediatrics 2012; 129: 1006–15.Google Scholar
Hamer, DH, Darmstadt, GL, Carlin, JB, et al. Etiology of bacteremia in young infants in six countries. Pediatr Infect Dis J 2015; 34: e18.Google Scholar
Waters, D, Jawad, I, Ahmad, A, et al. Aetiology of community-acquired neonatal sepsis in low and middle income countries. J Global Health 2011; 1: 154–70.Google Scholar
Schiano, MA, Hauth, JC, Gilstrap, LC 3rd. Second-stage fetal tachycardia and neonatal infection. Am J Obstet Gynecol 1984; 148: 779–81.Google Scholar
Soman, M, Green, B, Daling, J. Risk factors for early neonatal sepsis. Am J Epidemiol 1985; 121: 712–19.CrossRefGoogle ScholarPubMed
Escobar, GJ, Li, DK, Armstrong, MA, et al. Neonatal sepsis workups in infants weighing less than 2,000 grams at birth: a population-based study. Pediatrics 2000; 106: 256–63.Google Scholar
Baker, CJ. Group B streptococcal infections. Clin Perinatol 1997; 24: 5970.Google Scholar
Ottolini, MC, Lundgren, K, Mirkinson, LJ, et al. Utility of complete blood count and blood culture screening to diagnose neonatal sepsis in the asymptomatic at risk newborn. Pediatr Infect Dis J 2003; 22: 430–4.Google Scholar
Wortham, JM, Hansen, NI, Schrag, SJ, et al. Chorioamnionitis and culture-confirmed, early-onset neonatal infections. Pediatrics 2016; 137(1): e20152323.Google Scholar
World Health Organization (WHO). Pocket Book of Hospital Care for Children: Guidelines for the Management of Common Illnesses with Limited Resources: Geneva: WHO, 2005.Google Scholar
UNICEF, Organization WH. Caring for Newborns and Children in the Community: A Training Course for Community Health Workers. Caring for the Newborn at Home. New York: United Nations, 2015.Google Scholar
Group YICSS. Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet 2008; 371: 135–42.Google Scholar
Bomela, HN, Ballot, DE, Cory, BJ, Cooper, PA. Use of C-reactive protein to guide duration of empiric antibiotic therapy in suspected early neonatal sepsis. Pediatr Infect Dis J 2000; 19: 531–5.CrossRefGoogle ScholarPubMed
Townsend, TR, Shapiro, M, Rosner, B, Kass, EH. Use of antimicrobial drugs in general hospitals. IV. Infants and children. Pediatrics 1979; 64: 573–8.CrossRefGoogle ScholarPubMed
Paerregaard, A, Bruun, B, Andersen, GE, Witt, J. No advantage of capillary blood compared with venous blood for culture in neonates. Pediatr Infect Dis J 1989; 8: 659–60.CrossRefGoogle ScholarPubMed
Wiswell, TE, Hachey, WE. Multiple site blood cultures in the initial evaluation for neonatal sepsis during the first week of life. Pediatr Infect Dis J 1991; 10: 365–9.CrossRefGoogle ScholarPubMed
Sarkar, S, Bhagat, I, DeCristofaro, J, et al. A study of the role of multiple site blood cultures in the evaluation of neonatal sepsis. J Perinatol 2006; 26: 1822.CrossRefGoogle ScholarPubMed
Yaacobi, N, Bar-Meir, M, Shchors, I, Bromiker, R. A prospective controlled trial of the optimal volume for neonatal blood cultures. Pediatr Infect Dis J 2015; 34: 351–4.Google Scholar
Jardine, L, Davies, MW, Faoagali, J. Incubation time required for neonatal blood cultures to become positive. J Paediatr Child Health 2006; 42: 797802.CrossRefGoogle ScholarPubMed
Kumar, Y, Qunibi, M, Neal, T, Yoxall, C. Time to positivity of neonatal blood cultures. Arch Dis Child Fetal Neonat Ed 2001; 85: F182–6.Google Scholar
Liu, C, Ai, H, Wang, W, et al. Comparison of 16S rRNA gene PCR and blood culture for diagnosis of neonatal sepsis. Arch Pediatr 2014; 21: 162–9.Google Scholar
Visser, VE, Hall, RT. Urine culture in the evaluation of suspected neonatal sepsis. J Pediatr 1979; 94: 635–8.Google Scholar
DiGeronimo, RJ. Lack of efficacy of the urine culture as part of the initial workup of suspected neonatal sepsis. Pediatr Infect Dis J 1992; 11: 764–6.Google Scholar
Evans, ME, Schaffner, W, Federspiel, CF, et al. Sensitivity, specificity, and predictive value of body surface cultures in a neonatal intensive care unit. JAMA 1988; 259: 248–52.Google Scholar
Kite, P, Millar, MR, Gorham, P, Congdon, P. Comparison of five tests used in diagnosis of neonatal bacteraemia. Arch Dis Child 1988; 63: 639–43.Google Scholar
Schouten-Van Meeteren, NY, Rietveld, A, Moolenaar, AJ, Van Bel, F. Influence of perinatal conditions on C-reactive protein production. J Pediatr 1992; 120: 621–4.Google Scholar
Benitz, WE, Han, MY, Madan, A, Ramachandra, P. Serial serum C-reactive protein levels in the diagnosis of neonatal infection. Pediatrics 1998; 102: E41.Google Scholar
Jaye, DL, Waites, KB. Clinical applications of C-reactive protein in pediatrics. Pediatr Infect Dis J 1997; 16: 735–46; quiz 746–7.Google Scholar
Chiesa, C, Signore, F, Assumma, M, et al. Serial measurements of C-reactive protein and interleukin-6 in the immediate postnatal period: reference intervals and analysis of maternal and perinatal confounders. Clin Chem 2001; 47: 1016–22.Google Scholar
Laborada, G, Rego, M, Jain, A, et al. Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis. Am J Perinatol 2003; 20: 491501.Google Scholar
Hofer, N, Zacharias, E, Müller, W, Resch, B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 2012; 102: 2536.Google Scholar
Bhandari, V, Wang, C, Rinder, C, Rinder, H. Hematologic profile of sepsis in neonates: neutrophil CD64 as a diagnostic marker. Pediatrics 2008; 121: 129–34.Google Scholar
Kocabas, E, Sarikcioglu, A, Aksaray, N, et al. Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis. Turk J Pediatr 2007; 49: 720.Google ScholarPubMed
Ng, PC, Li, G, Chui, KM, et al. Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection. Pediatr Res 2004; 56: 796803.CrossRefGoogle ScholarPubMed
Santana Reyes, C, Garcia-Munoz, F, Reyes, D, et al. Role of cytokines (interleukin-1β, 6, 8, tumour necrosis factor-α, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis. Acta Paediatr 2003; 92: 221–7.Google Scholar
Franz, AR, Steinbach, G, Kron, M, Pohlandt, F. Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections. Pediatrics 1999; 104: 447–53.Google Scholar
Mohsen, AHA, Kamel, BA. Predictive values for procalcitonin in the diagnosis of neonatal sepsis. Electron Phys 2015; 7: 1190.Google Scholar
Sakha, K, Husseini, M, Seyyedsadri, N. The role of the procalcitonin in diagnosis of neonatal sepsis and correlation between procalcitonin and C-reactive protein in these patients. Pakistan J Biol Sci: PJBS 2008; 11: 1785–90.Google Scholar
Nupponen, I, Andersson, S, Jarvenpaa, AL, et al. Neutrophil cd11b expression and circulating interleukin-8 as diagnostic markers for early-onset neonatal sepsis. Pediatrics 2001; 108: E12.Google Scholar
Weirich, E, Rabin, RL, Maldonado, Y, et al. Neutrophil CD11b expression as a diagnostic marker for early-onset neonatal infection. J Pediatr 1998; 132: 445–1.CrossRefGoogle ScholarPubMed
Edgar, JD, Wilson, DC, McMillan, SA, et al. Predictive value of soluble immunological mediators in neonatal infection. Clin Sci (Colch) 1994; 87: 165–71.Google Scholar
Kennon, C, Overturf, G, Bessman, S, et al. Granulocyte colony-stimulating factor as a marker for bacterial infection in neonates. J Pediatr 1996; 128: 765–9.Google Scholar
Backes, RJ, Rouse, MS, Henry, NK, et al. Activity of penicillin combined with an aminoglycoside against group B streptococci in vitro and in experimental endocarditis. J Antimicrob Chemother 1986; 18: 491–8.Google Scholar
Starr, SE. Antimicrobial therapy of bacterial sepsis in the newborn infant. J Pediatr 1985; 106: 1043–8.Google Scholar
Jenson, HB, Pollock, BH. Meta-analyses of the effectiveness of intravenous immune globulin for prevention and treatment of neonatal sepsis. Pediatrics 1997; 99: E2.Google Scholar
Manroe, BL, Rosenfeld, CR, Weinberg, AG, Browne, R. The differential leukocyte count in the assessment and outcome of early-onset neonatal group B streptococcal disease. J Pediatr 1977; 91: 632–7.Google Scholar
Bilgin, K, Yaramis, A, Haspolat, K, et al. A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia. Pediatrics 2001; 107: 3641.Google Scholar
Gillan, ER, Christensen, RD, Suen, Y, et al. A randomized, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor administration in newborn infants with presumed sepsis: significant induction of peripheral and bone marrow neutrophilia. Blood 1994; 84: 1427–33.Google Scholar
Schibler, KR, Osborne, KA, Leung, LY, et al. A randomized, placebo-controlled trial of granulocyte colony-stimulating factor administration to newborn infants with neutropenia and clinical signs of early-onset sepsis. Pediatrics 1998; 102: 613.CrossRefGoogle ScholarPubMed
Tshefu, A, Lokangaka, A, Ngaima, S, et al. Simplified antibiotic regimens compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with clinical signs of possible serious bacterial infection when referral is not possible: a randomised, open-label, equivalence trial. Lancet 2015; 385: 1767–76.Google Scholar
Bennet, R, Eriksson, M, Zetterstrom, R. Neonatal septicemia: comparison of onset and risk factors during three consecutive 5-year periods. Acta Paediatr Scand 1987; 76: 361–2.Google Scholar
Mok, PM, Reilly, BJ, Ash, JM. Osteomyelitis in the neonate: clinical aspects and the role of radiography and scintigraphy in diagnosis and management. Radiology 1982; 145: 677–82.Google Scholar
Bennet, R, Bergdahl, S, Eriksson, M, Zetterstrom, R. The outcome of neonatal septicemia during fifteen years. Acta Paediatr Scand 1989; 78: 40–3.Google Scholar
Alfven, G, Bergqvist, G, Bolme, P, Eriksson, M. Longterm follow-up of neonatal septicemia. Acta Paediatr Scand 1978; 67: 769–73.Google Scholar
Sehdev, HM, Stamilio, DM, Macones, GA, et al. Predictive factors for neonatal morbidity in neonates with an umbilical arterial cord pH less than 7.00. Am J Obstet Gynecol 1997; 177: 1030–4.Google Scholar
Wu, YW. Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev 2002; 8: 25–9.Google Scholar
Arifeen, SE, Mullany, LC, Shah, R, et al. The effect of cord cleansing with chlorhexidine on neonatal mortality in rural Bangladesh: a community-based, cluster-randomised trial. Lancet 2012; 379: 1022–8.Google Scholar
Imdad, A, Mullany, LC, Baqui, AH, et al. The effect of umbilical cord cleansing with chlorhexidine on omphalitis and neonatal mortality in community settings in developing countries: a meta-analysis. BMC Public Health 2013; 13: S15.Google Scholar
Mullany, LC, Darmstadt, GL, Khatry, SK, et al. Topical applications of chlorhexidine to the umbilical cord for prevention of omphalitis and neonatal mortality in southern Nepal: a community-based, cluster-randomised trial. Lancet 2006; 367: 910–18.Google Scholar
World Health Organization (WHO). WHO Model List of Essential Medicines, 19th list (updated). Geneva: WHO, April 2015.Google Scholar
Darmstadt, GL, Badrawi, N, Law, PA, et al. Topically applied sunflower seed oil prevents invasive bacterial infections in preterm infants in Egypt: a randomized, controlled clinical trial. Pediatr Infect Dis J 2004; 23: 719–25.Google Scholar
Darmstadt, GL, Saha, SK, Ahmed, AS, et al. Effect of topical treatment with skin barrier-enhancing emollients on nosocomial infections in preterm infants in Bangladesh: a randomised controlled trial. Lancet 2005; 365: 1039–45.Google Scholar
Salam, RA, Darmstadt, GL, Bhutta, ZA. Effect of emollient therapy on clinical outcomes in preterm neonates in Pakistan: a randomised controlled trial. Arch Dis Child Fetal Neonat Ed 2015; 100: F210–15.Google Scholar
Salam, RA, Das, JK, Darmstadt, GL, Bhutta, ZA. Emollient therapy for preterm newborn infants: evidence from the developing world. BMC Public Health 2013; 13: 17.Google Scholar
Conde-Agudelo, A, Díaz-Rossello, J. Kangaroo mother care to reduce morbidity and mortality in low birth weight infants. Cochrane Database Syst Rev 2014; 4: CD002771.Google Scholar
Engmann, C, Wall, S, Darmstadt, G, et al. Consensus on kangaroo mother care acceleration. Lancet 2013; 382: e26–7.Google Scholar
Schuchat, A. Group B streptococcal disease: from trials and tribulations to triumph and trepidation. Clin Infect Dis 2001; 33: 751–6.Google Scholar
Schuchat, A. Epidemiology of group B streptococcal disease in the United States: shifting paradigms. Clin Microbiol Rev 1998; 11: 497513.Google Scholar
Davies, HD, Adair, C, McGeer, A, et al. Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: relationship to colonization status and infection in the neonate. J Infect Dis 2001; 184: 285–91.Google Scholar
Blumberg, HM, Stephens, DS, Modansky, M, et al. Invasive group B streptococcal disease: the emergence of serotype V. J Infect Dis 1996; 173: 365–73.Google Scholar
Klegerman, ME, Boyer, KM, Papierniak, CK, Gotoff, SP. Estimation of the protective level of human IgG antibody to the type-specific polysaccharide of group B Streptococcus type Ia. J Infect Dis 1983; 148: 648–55.CrossRefGoogle Scholar
Schuchat, A, Deaver-Robinson, K, Plikaytis, BD, et al. Multistate case-control study of maternal risk factors for neonatal group B streptococcal disease. The Active Surveillance Study Group. Pediatr Infect Dis J 1994; 13: 623–9.Google Scholar
Boyer, KM, Gotoff, SP. Prevention of early-onset neonatal group B streptococcal disease with selective intrapartum chemoprophylaxis. N Engl J Med 1986; 314: 1665–9.Google Scholar
CDC. Decreasing incidence of perinatal group B streptococcal disease – United States, 1993–1995. MMWR Morb Mortal Wkly Rep 1997; 46: 473.Google Scholar
Whitney, CG, Plikaytis, BD, Gozansky, WS, et al. Prevention practices for perinatal group B streptococcal disease: a multi-state surveillance analysis. Neonatal Group B Streptococcal Disease Study Group. Obstet Gynecol 1997; 89: 2832.Google Scholar
Schrag, S, Gorwitz, R, Fultz-Butts, K, Schuchat, A. Prevention of perinatal group B streptococcal disease. MMWR Recomm Rep 2002; 51: 122.Google Scholar
Centers for Disease Control and Prevention (CDC). Prevention of perinatal group B streptococcal disease: a public health perspective. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep 1996; 45: 124.Google Scholar
CDC. Diminishing racial disparities in early-onset neonatal group B streptococcal disease – United States, 2000–2003. MMWR Morb Mortal Wkly Rep 2004; 53: 502.Google Scholar
CDC. Perinatal group B streptococcal disease after universal screening recommendations–United States, 2003–2005. MMWR Morb Mortal Wkly Rep 2007; 56: 701–5.Google Scholar
CDC. Active bacterial core surveillance report: Streptococcus pneumoniae, 2009.Google Scholar
Ekelund, K, Konradsen, H. Invasive group B streptococcal disease in infants: a 19-year nationwide study. Serotype distribution, incidence and recurrent infection. Epidemiol Infect 2004; 132: 1083–90.Google Scholar
Phares, CR, Lynfield, R, Farley, MM, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA 2008; 299: 2056–65.Google Scholar
Katz, V, Bowes, WA Jr. Perinatal group B streptococcal infections across intact amniotic membranes. J Reprod Med 1988; 33: 445–9.Google Scholar
Dillon, HC Jr, Khare, S, Gray, BM. Group B streptococcal carriage and disease: a 6-year prospective study. J Pediatr 1987; 110: 31–6.Google Scholar
Trager, JD, Martin, JM, Barbadora, K, et al. Probable community acquisition of group B Streptococcus in an infant with late-onset disease: demonstration using field inversion gel electrophoresis. Arch Pediatr Adolesc Med 1996; 150: 766–8.Google Scholar
Ancona, RJ, Ferrieri, P, Williams, PP. Maternal factors that enhance the acquisition of group-B streptococci by newborn infants. J Med Microbiol 1980; 13: 273–80.Google Scholar
Regan, JA, Klebanoff, MA, Nugent, RP. The epidemiology of group B streptococcal colonization in pregnancy. Vaginal Infections and Prematurity Study Group. Obstet Gynecol 1991; 77: 604–10.Google Scholar
Curtis, J, Kim, G, Wehr, NB, Levine, RL. Group B streptococcal phospholipid causes pulmonary hypertension. Proc Natl Acad Sci USA 2003; 100: 5087–90.Google Scholar
CDC. Hospital-based policies for prevention perinatal group B streptococcal disease – United States, 1999. MMWR Morbid Mortal Wkly Rep 2000; 49: 936–40.Google Scholar
Bromberger, P, Lawrence, JM, Braun, D, et al. The influence of intrapartum antibiotics on the clinical spectrum of early-onset group B streptococcal infection in term infants. Pediatrics 2000; 106: 244–50.Google Scholar
Pulver, L, Hopfenbeck, M, Young, P, et al. Continued early onset group B streptococcal infections in the era of intrapartum prophylaxis. J Perinatol 2009; 29: 20–5.Google Scholar
Puopolo, KM, Madoff, LC, Eichenwald, EC. Early-onset group B streptococcal disease in the era of maternal screening. Pediatrics 2005; 115: 1240–6.Google Scholar
Maayan-Metzger, A, Barzilai, A, Keller, N, Kuint, J. Are the “good old” antibiotics still appropriate for early-onset neonatal sepsis? A 10 year survey. Israel Med Assoc J 2009; 11: 138.Google Scholar
Glass, P, Wagner, AE, Papero, PH, et al. Neurodevelopmental status at age five years of neonates treated with extracorporeal membrane oxygenation. J Pediatr 1995; 127: 447–57.Google Scholar
American Academy of Pediatrics Committee on Infectious Diseases and Committee on Fetus and Newborn. Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection. Pediatrics 1997; 99: 489–96.Google Scholar
American College of Obstetricians and Gynecologists. Prevention of Early-Onset Group B Streptococcal Disease in Newborns [Opinion 173]. Washington, DC: American College of Obstetricians and Gynecologists, 1996.Google Scholar
Rosenstein, NE, Schuchat, A. Opportunities for prevention of perinatal group B streptococcal disease: a multistate surveillance analysis. The Neonatal Group B Streptococcal Disease Study Group. Obstet Gynecol 1997; 90: 901–6.Google Scholar
Cueto, M, Sanchez, M, Sanpedro, A. Timing of intrapartum ampicillin and prevention of vertical transmission of group B streptococci. Obstet Gynecol 1998; 91: 112–14.Google Scholar
Hall, C, Easton, J, Granoff, D, et al. Guidelines for prevention of group B streptococcal (GBS) infection by chemoprophylaxis. Pediatrics 1992; 90: 775–8.Google Scholar
Gotoff, SP, Boyer, KM. Prevention of early-onset neonatal group B streptococcal disease. Pediatrics 1997; 99: 866–9.Google Scholar
Siegel, JD, Cushion, NB. Prevention of early-onset group B streptococcal disease: another look at single-dose penicillin at birth. Obstet Gynecol 1996; 87: 692–8.Google Scholar
Benitz, WE. The neonatal group B streptococcal debate. Pediatrics 1998; 101: 494–6.Google Scholar
Lieu, TA, Mohle-Boetani, JC, Ray, GT, et al. Neonatal group B streptococcal infection in a managed care population. Perinatal Group B Streptococcal Infection Study Group. Obstet Gynecol 1998; 92: 21–7.Google Scholar
Yow, MD, Mason, EO, Leeds, LJ, et al. Ampicillin prevents intrapartum transmission of group B Streptococcus. JAMA 1979; 241: 1245–7.Google Scholar
Heim, K, Alge, A, Marth, C. Anaphylactic reaction to ampicillin and severe complication in the fetus. Lancet 1991; 337: 859–60.Google Scholar
Towers, CV, Carr, MH, Padilla, G, Asrat, T. Potential consequences of widespread antepartal use of ampicillin. Am J Obstet Gynecol 1998; 179: 879–83.Google Scholar
Pylipow, M, Gaddis, M, Kinney, JS. Selective intrapartum prophylaxis for group B Streptococcus colonization: management and outcome of newborns. Pediatrics 1994; 93: 631–5.Google Scholar
Davis, RL, Hasselquist, MB, Cardenas, V, et al. Introduction of the new Centers for Disease Control and Prevention group B streptococcal prevention guideline at a large West Coast health maintenance organization. Am J Obstet Gynecol 2001; 184: 603–10.Google Scholar
Jaureguy, F, Carton, M, Panel, P, et al. Effects of intrapartum penicillin prophylaxis on intestinal bacterial colonization in infants. J Clin Microbiol 2004; 42: 5184–8.Google Scholar
Borchardt, SM, DeBusscher, JH, Tallman, PA, et al. Frequency of antimicrobial resistance among invasive and colonizing group B streptococcal isolates. BMC Infect Dis 2006; 6: 1.Google Scholar
Castor, ML, Whitney, CG, Como-Sabetti, K, et al. Antibiotic resistance patterns in invasive group B streptococcal isolates. Infect Dis Obstet Gynecol 2008; 2008: 727505.Google Scholar
Kasper, DL, Paoletti, LC, Wessels, MR, et al. Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine. J Clin Invest 1996; 98: 2308–14.Google Scholar
Baker, CJ, Paoletti, LC, Rench, MA, et al. Immune response of healthy women to two different group B streptococcal type V capsular polysaccharide-protein conjugate vaccines. J Infect Dis 2004; 189: 1103–12.CrossRefGoogle Scholar
Guttormsen, H-K, Liu, Y, Paoletti, LC. Functional activity of antisera to group B streptococcal conjugate vaccines measured with an opsonophagocytosis assay and HL-60 effector cells. Human Vaccines 2008; 4: 370–4.CrossRefGoogle Scholar
Buccato, S, Maione, D, Rinaudo, CD, et al. Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease. J Infect Dis 2006; 194: 331–40.Google Scholar
Rosini, R, Rinaudo, CD, Soriani, M, et al. Identification of novel genomic islands coding for antigenic pilus‐like structures in Streptococcus agalactiae. Mol Microbiol 2006; 61: 126–41.Google Scholar
Hillier, S, Ferris, D, Fine, D, Ferrieri, P. Women receiving group B Streptococcus serotype III tetanus toxoid (GBS III-TT) vaccine have reduced vaginal and rectal acquisition of GBS type III. Presented at the 47th Annual Meeting of the IDSA, 2009.Google Scholar
Le Doare, K, Heath, PT. An overview of global GBS epidemiology. Vaccine 2013; 31(Suppl 4): D712.Google Scholar
Edmond, KM, Kortsalioudaki, C, Scott, S, et al. Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis. Lancet 2012; 379: 547–56.Google Scholar
Bingen, E, Picard, B, Brahimi, N, et al. Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains. J Infect Dis 1998; 177: 642–50.Google Scholar
Sarff, LD, McCracken, GH, Schiffer, MS, et al. Epidemiology of Escherichia coli K1 in healthy and diseased newborns. Lancet 1975; 1: 1099–104.Google Scholar
McCracken, GH Jr, Sarff, LD, Glode, MP, et al. Relation between Escherichia coli K1 capsular polysaccharide antigen and clinical outcome in neonatal meningitis. Lancet 1974; 2: 246–50.Google Scholar
Guerina, NG, Kessler, TW, Guerina, VJ, et al. The role of pili and capsule in the pathogenesis of neonatal infection with Escherichia coli K1. J Infect Dis 1983; 148: 395405.Google Scholar
Mayor-Lynn, K, Gonzalez-Quintero, VH, O’Sullivan, MJ, et al. Comparison of early-onset neonatal sepsis caused by Escherichia coli and group B Streptococcus. Am J Obstet Gynecol 2005; 192: 1437–9.Google Scholar
Alarcon, A, Pena, P, Salas, S, et al. Neonatal early onset Escherichia coli sepsis: trends in incidence and antimicrobial resistance in the era of intrapartum antimicrobial prophylaxis. Pediatr Infect Dis J 2004; 23: 295–9.Google Scholar
Charles, D, Larsen, B. Streptococcal puerperal sepsis and obstetric infections: a historical perspective. Rev Infect Dis 1986; 8: 411–22.Google Scholar
Chuang, I, Van Beneden, C, Beall, B, et al. Population-based surveillance for postpartum invasive group A Streptococcus infections, 1995–2000. Clin Infect Dis 2002; 35: 665–70.Google Scholar
Miyairi, I, Berlingieri, D, Protic, J, Belko, J. Neonatal invasive group A streptococcal disease: case report and review of the literature. Pediatr Infect Dis J 2004; 23: 161–5.Google Scholar
Greenberg, D, Leibovitz, E, Shinnwell, ES, et al. Neonatal sepsis caused by Streptococcus pyogenes: resurgence of an old etiology? Pediatr Infect Dis J 1999; 18: 479–81.Google Scholar
Macris, MH, Hartman, N, Murray, B, et al. Studies of the continuing susceptibility of group A streptococcal strains to penicillin during eight decades. Pediatr Infect Dis J 1998; 17: 377–81.Google Scholar
Kaplan, EL, Johnson, DR, Del Rosario, MC, Horn, DL. Susceptibility of group A beta-hemolytic streptococci to thirteen antibiotics: examination of 301 strains isolated in the United States between 1994 and 1997. Pediatr Infect Dis J 1999; 18: 1069–72.Google Scholar
Norrby-Teglund, A, Ihendyane, N, Kansal, R, et al. Relative neutralizing activity in polyspecific IgM, IgA, and IgG preparations against group A streptococcal superantigens. Clin Infect Dis 2000; 31: 1175–82.Google Scholar
Zimbelman, J, Palmer, A, Todd, J. Improved outcome of clindamycin compared with beta-lactam antibiotic treatment for invasive Streptococcus pyogenes infection. Pediatr Infect Dis J 1999; 18: 1096–100.Google Scholar
Dobson, SR, Baker, CJ. Enterococcal sepsis in neonates: features by age at onset and occurrence of focal infection. Pediatrics 1990; 85: 165–71.Google Scholar
McNeeley, DF, Saint-Louis, F, Noel, GJ. Neonatal enterococcal bacteremia: an increasingly frequent event with potentially untreatable pathogens. Pediatr Infect Dis J 1996; 15: 800–5.Google Scholar
Murray, BE. The life and times of the Enterococcus. Clin Microbiol Rev 1990; 3: 4665.Google Scholar

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