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Chapter 3 - Neuroprotective Strategies in the Pediatric Patient

Published online by Cambridge University Press:  02 November 2018

By
Rebecca Dube  and
Jason T. Maynes
Edited by
Sulpicio G. Soriano  and
Craig D. McClain
Sulpicio G. Soriano
Affiliation:
Boston Children’s Hospital
Craig D. McClain
Affiliation:
Boston Children’s Hospital
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Essentials of Pediatric Neuroanesthesia , pp. 15 - 22
Publisher: Cambridge University Press
Print publication year: 2018

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References

Casaccia-Bonnefil, P. Cell death in the oligodendrocyte lineage: a molecular perspective of life/death decisions in development and disease. Glia. 2000;29(2):124–35.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Chang, E. Preterm birth and the role of neuroprotection. BMJ. 2015;350:g6661.CrossRefGoogle ScholarPubMed
Shea, KL, Palanisamy, A. What can you do to protect the newborn brain? Curr Opin Anaesthesiol. 2015;28(3):261–6.Google Scholar
Johnston, MV. Excitotoxicity in perinatal brain injury. Brain Pathol. 2005;15(3):234–40.Google Scholar
Clarkson, AN. Anesthetic-mediated protection/preconditioning during cerebral ischemia. Life Sci. 2007;80(13):1157–75.CrossRefGoogle ScholarPubMed
Kukreti, V, Mohseni-Bod, H, Drake, J. Management of raised intracranial pressure in children with traumatic brain injury. J Pediatr Neurosci. 2014;9(3):207–15.Google ScholarPubMed
Laffey, JG, Kavanagh, BP. Hypocapnia. N Engl J Med. 2002;347(1):43–53.CrossRefGoogle ScholarPubMed
Shao, L, Hong, F, Zou, Y, Hao, X, Hou, H, Tian, M. Hypertonic saline for brain relaxation and intracranial pressure in patients undergoing neurosurgical procedures: a meta-analysis of randomized controlled trials. PLOS ONE. 2015;10(1):e0117314.CrossRefGoogle ScholarPubMed
Dostal, P, Schreiberova, J, Dostalova, V, Tyll, T, Paral, J, Abdo, I, et al. Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model. BMC Anesthesiol. 2015;15(1):88.CrossRefGoogle Scholar
Stilling, M, Karatasi, E, Rasmussen, M, Tankisi, A, Juul, N, Cold, GE. Subdural intracranial pressure, cerebral perfusion pressure, and degree of cerebral swelling in supra- and infratentorial space-occupying lesions in children. Acta Neurochir Suppl. 2005;95:133–6.CrossRefGoogle ScholarPubMed
Jacobs, SE, Berg, M, Hunt, R, Tarnow-Mordi, WO, Inder, TE, Davis, PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013;(1):CD003311.Google ScholarPubMed
Azzopardi, D, Strohm, B, Marlow, N, Brocklehurst, P, Deierl, A, Eddama, O, et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N Engl J Med. 2014;371(2):140–9.Google Scholar
Hindman, BJ, Bayman, EO, Pfisterer, WK, Torner, JC, Todd, MM, Investigators, IHAST. No association between intraoperative hypothermia or supplemental protective drug and neurologic outcomes in patients undergoing temporary clipping during cerebral aneurysm surgery: findings from the Intraoperative Hypothermia for Aneurysm Surgery Trial. Anesthesiology. 2010;112(1):86–101.CrossRefGoogle ScholarPubMed
Sonneville, R, Vanhorebeek, I, den HM, Hertog, Chrétien, F, Annane, D, Sharshar, T, et al. Critical illness-induced dysglycemia and the brain. Intensive Care Med. 2015;41(2):192–202.CrossRefGoogle ScholarPubMed
Ntaios, G, Egli, M, Faouzi, M, Michel, P. J-shaped association between serum glucose and functional outcome in acute ischemic stroke. Stroke. 2010;41(10):2366–70.Google Scholar
de Ferranti, S, Gauvreau, K, Hickey, PR, Jonas, RA, Wypij, D, Plessis du A, et al. Intraoperative hyperglycemia during infant cardiac surgery is not associated with adverse neurodevelopmental outcomes at 1, 4, and 8 years. Anesthesiology. 2004;100(6):1345–52.Google Scholar
Fairbanks, SL, Brambrink, AM. Preconditioning and postconditioning for neuroprotection: the most recent evidence. Best Pract Res Clin Anaesthesiol. 2010;24(4):521–34.CrossRefGoogle ScholarPubMed
Hudetz, JA, Patterson, KM, Iqbal, Z, Gandhi, SD, Pagel, PS. Remote ischemic preconditioning prevents deterioration of short-term postoperative cognitive function after cardiac surgery using cardiopulmonary bypass: results of a pilot investigation. J Cardiothorac Vasc Anesth. 2015;29(2):382–8.Google Scholar
Zwerus, R, Absalom, A. Update on anesthetic neuroprotection. Curr Opin Anaesthesiol. 2015;28(4):424–30.Google Scholar
Wells, BA, Keats, AS, Cooley, DA. Increased tolerance to cerebral ischemia produced by general anesthesia during temporary carotid occlusion. Surgery. 1963;54:216–23.Google ScholarPubMed
Matchett, GA, Allard, MW, Martin, RD, Zhang, JH. Neuroprotective effect of volatile anesthetic agents: molecular mechanisms. Neurol Res. 2009;31(2):128–34.CrossRefGoogle ScholarPubMed
Bilotta, F, Stazi, E, Zlotnik, A, Gruenbaum, SE, Rosa, G. Neuroprotective effects of intravenous anesthetics: a new critical perspective. Curr Pharm Des. 2014;20(34):5469–75.CrossRefGoogle ScholarPubMed
Schifilliti, D, Grasso, G, Conti, A, Fodale, V. Anaesthetic-related neuroprotection: intravenous or inhalational agents? CNS Drugs. 2010;24(11):893–907.Google Scholar
Elsersy, H, Sheng, H, Lynch, JR, Moldovan, M, Pearlstein, RD, Warner, DS. Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. Anesthesiology. 2004;100(5):1160–6.Google Scholar
Elsersy, H, Mixco, J, Sheng, H, Pearlstein, RD, Warner, DS. Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection. Anesthesiology. 2006;105(1):81–90.CrossRefGoogle ScholarPubMed
Engelhard, K, Werner, C, Reeker, W, Lu, H, Möllenberg, O, Mielke, L, et al. Desflurane and isoflurane improve neurological outcome after incomplete cerebral ischaemia in rats. Br J Anaesth. 1999;83(3):415–21.CrossRefGoogle ScholarPubMed
Lai, Z, Zhang, L, Su, J, Cai, D, Xu, Q. Sevoflurane postconditioning improves long-term learning and memory of neonatal hypoxia-ischemia brain damage rats via the PI3 K/Akt-mPTP pathway. Brain Res. 2016;1630:25–37.Google Scholar
Haelewyn, B, Yvon, A, Hanouz, JL, MacKenzie, ET, Ducouret, P, Gérard, JL, et al. Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat. Br J Anaesth. 2003;91(3):390–6.Google Scholar
Jevtovic-Todorovic, V, Todorović, SM, Mennerick, S, Powell, S, Dikranian, K, Benshoff, N, et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med. 1998;4(4):460–3.Google Scholar
Haelewyn, B, David, HN, Rouillon, C, Chazalviel, L, Lecocq, M, Risso, J-J, et al. Neuroprotection by nitrous oxide: facts and evidence. Crit Care Med. 2008;36(9):2651–9.CrossRefGoogle ScholarPubMed
Wilhelm, S, Ma, D, Maze, M, Franks, NP. Effects of xenon on in vitro and in vivo models of neuronal injury. Anesthesiology. 2002;96(6):1485–91.CrossRefGoogle ScholarPubMed
David, HN, Leveille, F, Chazalviel, L, MacKenzie, ET, Buisson, A, Lemaire, M, et al. Reduction of ischemic brain damage by nitrous oxide and xenon. J Cereb Blood Flow Metab. 2003;23(10):1168–73.Google Scholar
Metaxa, V, Lagoudaki, R, Meditskou, S, Thomareis, O, Oikonomou, L, Sakadamis, A. Delayed post-ischaemic administration of xenon reduces brain damage in a rat model of global ischaemia. Brain Inj. 2014;28(3):364–9.CrossRefGoogle Scholar
Ma, D, Hossain, M, Chow, A, Arshad, M, Battson, RM, Sanders, RD, et al. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol. 2005;58(2):182–93.Google Scholar
Dingley, J, Tooley, J, Liu, X, Scull-Brown, E, Elstad, M, Chakkarapani, E, et al. Xenon ventilation during therapeutic hypothermia in neonatal encephalopathy: a feasibility study. Pediatrics. 2014;133(5):809–18.Google Scholar
Zaidan, JR, Klochany, A, Martin, WM, Ziegler, JS, Harless, DM, Andrews, RB. Effect of thiopental on neurologic outcome following coronary artery bypass grafting. Anesthesiology. 1991;74(3):406–11.CrossRefGoogle ScholarPubMed
Gelb, AW, Bayona, NA, Wilson, JX, Cechetto, DF. Propofol anesthesia compared to awake reduces infarct size in rats. Anesthesiology. 2002;96(5):1183–90.Google Scholar
Engelhard, K, Werner, C, Eberspächer, E, Pape, M, Stegemann, U, Kellermann, K, et al. Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation. Anesthesiology. 2004;101(4):912–17.Google Scholar
Adembri, C, Venturi, L, Pellegrini-Giampietro, DE. Neuroprotective effects of propofol in acute cerebral injury. CNS Drug Rev. 2007;13(3):333–51.Google Scholar
Roach, GW, Newman, MF, Murkin, JM, Martzke, J, Ruskin, A, Li, J, et al. Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Anesthesiology. 1999;90(5):1255–64.Google Scholar
Proescholdt, M, Heimann, A, Kempski, O. Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. Brain Res. 2001;904(2):245–51.CrossRefGoogle ScholarPubMed
Hudetz, JA, Pagel, PS. Neuroprotection by ketamine: a review of the experimental and clinical evidence. J Cardiothorac Vasc Anesth. 2010;24(1):131–42.Google Scholar
Hudetz, JA, Patterson, KM, Iqbal, Z, Gandhi, SD, Byrne, AJ, Hudetz, AG, et al. Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2009;23(5):651–7.CrossRefGoogle ScholarPubMed
Soriano, SG, Liu, Q, Li, J, Liu, J-R, Han, XH, Kanter, JL, et al. Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology. 2010;112(5):1155–63.CrossRefGoogle ScholarPubMed
Lei, B, Popp, S, Capuano-Waters, C, Cottrell, JE, Kass, IS. Effects of delayed administration of low-dose lidocaine on transient focal cerebral ischemia in rats. Anesthesiology. 2002;97(6):1534–40.CrossRefGoogle ScholarPubMed
Ren, X, Ma, H, Zuo, Z. Dexmedetomidine postconditioning reduces brain injury after brain hypoxia-ischemia in neonatal rats. J Neuroimmune Pharmacol. 2016;11(2):238–47.CrossRefGoogle ScholarPubMed
Sanders, RD, Xu, J, Shu, Y, Januszewski, A, Halder, S, Fidalgo, A, et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology. 2009;110(5):1077–85.CrossRefGoogle ScholarPubMed
Ge, Y-L, Li, X, Gao, JU, Zhang, X, Fang, X, Zhou, L, et al. Beneficial effects of intravenous dexmedetomidine on cognitive function and cerebral injury following a carotid endarterectomy. Exp Ther Med. 2016;11(3):1128–34.Google Scholar

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