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Section 4 - ADEM

Published online by Cambridge University Press:  11 April 2011

Dorothée Chabas
Affiliation:
University of California, San Francisco
Emmanuelle L. Waubant
Affiliation:
University of California, San Francisco
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Summary

This chapter focuses on the clinical features of the pathophysiology of acute disseminated encephalomyelitis (ADEM) in children. ADEM can occur at any age, but is more common in pediatric patients than in adults. Few systematic population-based studies have been performed to address the incidence and geographic distribution of ADEM. ADEM was more frequently associated with pediatric exanthematous infections. ADEM is usually a monophasic illness presenting with neurological symptoms and signs within 2 days to 4 weeks after an antecedent event. Neuroimaging studies are useful and essential tools in establishing the diagnosis of ADEM. Fever, encephalopathy, and neurological signs and symptoms are by nature frequent presenting features of ADEM. Many inflammatory and non-inflammatory disorders of the central nervous system (CNS) may have similar clinical and neuroimaging presentation. Patients who do not have encephalopathy are categorized as having a clinical isolated syndrome (CIS).
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Publisher: Cambridge University Press
Print publication year: 2011

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  • ADEM
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.018
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  • ADEM
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.018
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • ADEM
  • Edited by Dorothée Chabas, University of California, San Francisco, Emmanuelle L. Waubant, University of California, San Francisco
  • Book: Demyelinating Disorders of the Central Nervous System in Childhood
  • Online publication: 11 April 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511974373.018
Available formats
×