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12 - Important Concepts about Second-Generation Antipsychotics

Published online by Cambridge University Press:  19 October 2021

Jonathan M. Meyer
Affiliation:
University of California, San Diego
Stephen M. Stahl
Affiliation:
University of California, Riverside and San Diego
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Summary

While FGAs share the common mechanism of action (MOA) of D2 antagonism, SGAs are a heterogeneous group that includes agents with limited D2 occupancy and the dopamine partial agonists [3]. Among SGAs whose principal MOA is D2 blockade, positron imaging tomography (PET) studies indicate that the ‘sweet spot’ for receptor occupancy is the same as for FGAs, 65%–80%, with decreased response rates below this threshold, and greater risk for neurological adverse effects above 80% [18].

Type
Chapter
Information
The Clinical Use of Antipsychotic Plasma Levels
Stahl's Handbooks
, pp. 241 - 248
Publisher: Cambridge University Press
Print publication year: 2021

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References

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