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6 - Important Concepts about First-Generation Antipsychotics

Published online by Cambridge University Press:  19 October 2021

Jonathan M. Meyer
University of California, San Diego
Stephen M. Stahl
University of California, Riverside and San Diego
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First-generation antipsychotics (FGAs) have no unique therapeutic benefit compared to newer antipsychotics, but their utility derives from the fact that they are inexpensive, that multiple formulations exist including long-acting injectable (LAI) preparations, and that there is an extensive trove of plasma level studies for the more commonly used medications [1–5]. Large randomized trials such as the UK Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS-1) (n = 227) found that there was no disadvantage over 1 year of treatment in terms of quality of life, symptoms, or associated costs of care when using FGAs, compared to second-generation antipsychotics (SGAs) (clozapine excepted) [6].

The Clinical Use of Antipsychotic Plasma Levels
Stahl's Handbooks
, pp. 147 - 156
Publisher: Cambridge University Press
Print publication year: 2021

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