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11 - Chlorpromazine, Loxapine, Thiothixene, Trifluoperazine

Published online by Cambridge University Press:  19 October 2021

Jonathan M. Meyer
University of California, San Diego
Stephen M. Stahl
University of California, Riverside and San Diego
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As discussed in Chapter 6, first-generation antipsychotics (FGAs) are therapeutically as effective as newer antipsychotics, and their utility derives from low cost and the availability of long-acting injectable (LAI) preparations for certain agents. While there are close to 3 dozen FGAs available worldwide, many have very limited or regional use (e.g. melperone, chlorprothixene, perazine), some are rarely used (thioridazine, pimozide) due to disproportionate effects on the rate-corrected QT interval (QTc) of the EKG, and some are so poorly characterized that plasma level data is virtually nonexistent (molindone).

The Clinical Use of Antipsychotic Plasma Levels
Stahl's Handbooks
, pp. 217 - 240
Publisher: Cambridge University Press
Print publication year: 2021

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