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6.4 - Inflammation and Immune Responses

from 6 - Modulators

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
University of Cambridge
Peter B. Jones
University of Cambridge
Stephen M. Stahl
University of California, San Diego
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Multiple psychiatric disorders have been associated with abnormalities in the immune system and evidence from human and animal studies suggests that the immune system is likely to be implicated in the pathogenesis of these disorders, at least in a subset of patients. However, our understanding of how the immune system contributes to symptoms in humans is in its infancy. Moreover, translating this new understanding to improved clinical care will require biomarkers of immune dysfunction that allow us to identify which patients might benefit from alternative immunomodulatory treatment approaches. Following a brief primer on the immune system and its relationship to the brain, this chapter summarises the immune abnormalities associated with psychiatric disorders in case–control studies, outlines the evidence for a causal contribution of immunopathology to psychiatric conditions and considers possible sources of the observed inflammation.

Publisher: Cambridge University Press
Print publication year: 2023

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