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Intervention development frameworks offer the behavioral sciences a systematic and rigorous empirical process to guide the translation of basic science into practice in pursuit of desirable public health and clinical outcomes. The multiple frameworks that have emerged share a goal of optimization during intervention development and can increase the likelihood of arriving at an effective and disseminable intervention. Yet, the process of optimizing an intervention differs functionally and conceptually across frameworks, creating confusion and conflicting guidance on when and how to optimize. This paper seeks to facilitate the use of translational intervention development frameworks by providing a blueprint for selecting and using a framework by considering the process of optimization as conceptualized by each. First, we operationalize optimization and contextualize its role in intervention development. Next, we provide brief overviews of three translational intervention development frameworks (ORBIT, MRC, and MOST), identifying areas of overlap and divergence thereby aligning core concepts across the frameworks to improve translation. We offer considerations and concrete use cases for investigators seeking to identify and use a framework in their intervention development research. We push forward an agenda of a norm to use and specify frameworks in behavioral science to support a more rapid translational pipeline.
Transorbital endoscopic approaches are becoming increasingly popular for skull base pathologies; the superior lateral orbital portal is one such approach to the middle cranial fossa. This paper provides a technical description that maximises the surgical portal and minimises morbidity.
Technical description
A superior lid crease incision is made extending laterally and the orbital rim is exposed. A subperiosteal dissection of the lateral and superior orbit is performed, with elevation of periosteum off Whitnall's tubercle, ligation of the recurrent branch of the middle meningeal artery, and identification of the superior orbital fissure. The lacrimal keyhole is then drilled away. The middle cranial fossa is accessed by drilling posterior to the orbital rim to expose: the temporalis muscle anterior-laterally, the dura of the temporal lobe posterior-laterally, the anterior cranial fossa superiorly and the periorbita medially.
Conclusion
These surgical steps can maximise the surgical portal and minimise morbidity, with avoidance of injury to surrounding structures.
To review the clinical characteristics, prevalence and outcomes of chronic rhinosinusitis patients with a hypoplastic maxillary sinus who underwent functional endoscopic sinus surgery.
Methods
A retrospective review was performed for the 814 consecutive, elective functional endoscopic sinus surgery procedures performed at an academic centre from 2010 to 2020, to identify patients with a hypoplastic maxillary sinus.
Result
A total of 56 hypoplastic maxillary sinus cases were detected. Maxillary sinus hypoplasia presented unilaterally in 20 cases and bilaterally in 18 cases. Of the maxillary sinus hypoplasia cases, 38 were type I, 17 were type II and 1 was type III. The average Lund–McKay score was 8.6. No major post-operative complications were reported. Four patients had minor complications and one had persistent post-nasal drip.
Conclusion
Functional endoscopic sinus surgery is a safe and effective procedure for improving the clinical condition of patients with a hypoplastic maxillary sinus; however, careful pre-operative radiological evaluation, identification of intra-operative endoscopic landmarks and use of additional techniques may be essential to achieve satisfactory results and avoid possible serious complications.
Here, I inspect the layout of our own solar system, and consider the extent to which other planetary systems are similar or different. Discoveries so far show that there are many possible layouts, and suggest that quasi-replicates of our system, with four inner rocky planets and four outer giant planets (gaseous or icy) are rare. Every system is different from every other one. This is a consequence of the chaotic process of collisions that leads from a protoplanetary disc to planets. Planets can be found orbiting large, medium, and small stars – with consequences for their maximum lifespans. Some planets are found in binary systems and even in systems with more than two stars. The nearest system to ours – Alpha Centauri – has three stars. This system has at least one planet, which orbits the smallest of the three stars. Planetary systems are also thought to typically contain smaller bodies than planets, as seen in the solar system – moons, minor planets, asteroids, and comets. Life is most likely to occur on planets, but life on moons is also possible. Finally, there are some lone planets that do not orbit a star at all. These are the least probable homes for life.
In 1543, Nicolaus Copernicus published a radical new theory of the heavens. He proposed that the Earth rotates on its axis while the celestial sphere remains stationary. He also placed the Sun at rest near the center of the celestial sphere, while the Earth and other planets orbited around the Sun. Copernicus’ heliocentric theory could account for the motions of the stars, Sun, and planets about as well as Ptolemy’s theory did. It also helped to explain certain features of planetary motion that were mysterious in Ptolemy’s model. However, the idea that the Earth moved was too revolutionary for most of Copernicus’ contemporaries. While Copernicus believed that his model represented the real motions of the universe, most of his readers denied the Earth’s motion and accepted Copernicus' theory as nothing more than a useful mathematical device.
A relational structure is called reversible iff each bijective endomorphism (condensation) of that structure is an automorphism. We show that reversibility is an invariant of some forms of L∞ω −bi-interpretability, implying that the condensation monoids of structures are topologically isomorphic. Applying these results, we prove that, in particular, all orbits of ultrahomogeneous tournaments and reversible ultrahomogeneous m-uniform hypergraphs are reversible relations and that the same holds for the orbits of reversible ultrahomogeneous digraphs definable by formulas which are not R-negative.
Multi-wave astronomy provides a means for researchers to see and ‘hear’ the sky. But that is only part of their perception of the cosmos. The hot handshake of the Universe in the form of a meteor substance burning in the Earth’s atmosphere, sometimes with the precipitation of meteorites threatening the environment, occurs every second. A major present challenge for meteor research is organizing observations and processing existing and new data in order to obtain information in the time domain of meteor astronomy for solving special problems. This poster discusses the concept of the meteor sky, and some approaches for constructing models of it. The database of meteors of Kharkiv National University of Radio Electronics was used.
In this paper we prove the following theorem. Let $f$ be a dominant polynomial endomorphism of the affine plane defined over an algebraically closed field of characteristic $0$. If there is no nonconstant invariant rational function under $f$, then there exists a closed point in the plane whose orbit under $f$ is Zariski dense. This result gives us a positive answer to a conjecture proposed by Medvedev and Scanlon, by Amerik, Bogomolov and Rovinsky, and by Zhang for polynomial endomorphisms of the affine plane.
This case report presents our experience of endoscopic transnasal management of medial intra- and extraconal lesions.
Case report:
An endoscopic transnasal approach to intra-orbital lesions was used for nine patients. Four patients had intraconal lesions and five had lesions in the extraconal space. Post-operatively, seven patients reported an improvement in visual acuity and two reported stable vision. There were no complications of cerebrospinal leakage or diplopia.
Conclusion:
This case series demonstrated the safety and effectiveness of an endoscopic transnasal approach to managing intraconal and extraconal lesions. This minimally invasive technique should be considered a valid alternative for accessing orbital tumours, particularly those located in the medial compartment.
The Orbit demand model allows the magnitude of the calibration to stated purchase intentions to vary based on the magnitude of the stated quantities. Using an empirical example of stated trips, we find that the extent of calibration varies substantially with less correction needed at small stated trips (-25%) but larger corrections at higher quantities of stated visits (-48%). We extend the Orbit model to calculate consumer surplus per stated trip of $26. Combining the calibrations in stated trips and value per trip, the Orbit model provides estimates of annual benefits from 60% to 111% less than the count data model.
We give a complete characterization of a hypercyclic abelian semigroup of matrices on ℂn. For finitely generated semigroups, this characterization is explicit and it is used to determine the minimal number of matrices in normal form over ℂ that form a hypercyclic abelian semigroup on ℂn. In particular, we show that no abelian semigroup generated by n matrices on ℂn can be hypercyclic.
We give a characterization of hypercyclic abelian group $\mathcal{G}$ of affine maps on ${{\mathbb{C}}^{n}}$. If $\mathcal{G}$ is finitely generated, this characterization is explicit. We prove in particular that no abelian group generated by $n$ affine maps on ${{\mathbb{C}}^{n}}$ has a dense orbit.
Small bodies of 100–500 m diameter can cause significant damage on impact with the Earth. Such objects are difficult to detect and track because they are intrinsically faint over most of their orbit. We failed to detect one such lost and potentially hazardous minor planet, 1998 OX4, during two observing sessions in 2001, January. The positions searched were those calculated by Milani et al. (2000) with their Virtual Impactors method. Using some simple assumptions we estimate the probability that we failed to detect 1998 OX4 due to it being obscured by objects in the field of our observations is <2 × 10−7. If the assumptions in the Virtual Impactor model are valid we conclude that an impact with 1998 OX4 is unlikely in 2014, January. Furthermore, given the relatively large area we searched it is also unlikely that this minor planet will have a very close encounter with Earth in 2014.
To investigate differences in orbital involvement in patients with invasive versus non-invasive fungal sinusitis.
Method:
One hundred consecutive cases of fungal sinusitis were assessed clinically and by computed tomography scan to evaluate orbital involvement.
Results:
Clinical orbital involvement was more common in invasive (73.5 per cent) than non-invasive (12.1 per cent) fungal sinusitis (p = 0.000). Computed tomography scanning showed similar orbital involvement in both groups, except for erosion of the floor of the orbit, which was more common in patients with invasive fungal sinusitis (p = 0.01). Extra-ocular muscle enlargement (44.4 vs 4 per cent, p = 0.01) and optic atrophy (44.4 vs 0 per cent, p = 0.003) were more common in chronic than acute invasive fungal sinusitis. Four patients (16 per cent) with acute invasive fungal sinusitis had no evidence of orbital involvement on scanning, despite clinical evidence of optic atrophy.
Conclusion:
Orbital involvement is more common in invasive than non-invasive fungal sinusitis. The difference is more evident clinically than on computed tomography scanning. Patients with acute invasive fungal sinusitis may have limited evidence of orbital involvement on scanning, despite extensive clinical disease.
We present the first report in the all English literature of a case of laryngeal squamous cell carcinoma metastasis to the orbit.
Method:
Case report of orbital metastasis from laryngeal carcinoma; clinical, radiological and pathological findings are discussed.
Result:
A 75-year-old man presented to the ENT department with a five-week history of left orbital pain, swelling and reduced vision. Past medical history included laryngectomy, bilateral neck dissection and post-operative radiotherapy for T4 N2c M0 squamous cell carcinoma of the supraglottis, 10 months earlier. Imaging showed an orbital mass extending along the roof and lateral aspect of the orbit into the optic canal and superior orbital fissure, and further posteriorly into the left cavernous sinus with meningeal enhancement in the left anterior cranial fossa. Histopathological analysis after biopsy showed the mass to be consistent with metastatic poorly differentiated squamous cell carcinoma.
Conclusion:
After searching the all English literature, we report what is, to our best knowledge, the first case of laryngeal carcinoma metastasis to the orbit. Despite its rarity and poor prognosis, such a metastasis should be considered as part of the differential diagnosis of an orbital mass, as timely recognition can improve the patient's quality of life.
Verrucous carcinoma is a variant of well differentiated squamous cell carcinoma characterised by an exophytic, warty growth which is slowly but locally invasive and which can cause extensive local destruction if left untreated.
Case report:
We report the first known case of veruccous carcinoma of the paranasal sinuses with rapid orbital invasion. A 58-year-old man presented with right-sided nasal obstruction, a huge right intranasal lesion, intractable dacryocystitis and cutaneous involvement of the nasolacrimal sac region. The tumour was partially removed using an endoscopic transnasal approach. Post-operatively, and while waiting for the histological result, the patient developed signs of rapid invasion of the orbit, with uniocular visual acuity deficit. He underwent combined radiochemotherapy, with a moderate response.
Conclusion:
Knowledge of the potentially aggressive nature of verrucous carcinoma may be helpful in early management of intraorbital invasion and salvaging of the eye.
In this paper, we present a new method of enumeration of parallel manipulators with one end-effector. The method consists of enumerating all the manipulators possible with one end-effector that a single kinematic chain can originate. A very useful simplification for kinematic chain, mechanism and manipulator enumeration is their representation through graphs. The method is based on group theory where abstract structures are used to capture the internal symmetry of a structure in the form of automorphisms of a group. The concept used is orbits of the group of automorphisms of a colored vertex graph. The theory and some examples are presented to illustrate the method.
The use of ultrasound in acute trauma has increased dramatically over the past 30 years. The oldest and most established indication for ultrasound in the ED is blunt abdominal trauma. The focused assessment with sonography in trauma (FAST) exam has become a standard imaging modality in the setting of acute trauma and is incorporated into the American College of Surgeons' Advanced Trauma Life Support guidelines. In the setting of acute cranial trauma, ultrasound may be useful in the detection of elevated intracranial pressure. Thoracoabdominal sonography can be limited by patient body habitus. In the abdomen, bowel gas, subcutaneous emphysema, pneumoperitoneum, and rib shadows can hinder evaluation of deeper structures. Evaluation of the heart and thorax can be limited by rib shadows, emphysematous lungs, or subcutaneous emphysema. Imaging the orbit should be done with care; no pressure should be applied to the eye, which causes retinal detachment or a ruptured globe.
Although uncommon, ocular complications of endoscopic sinus surgery have the potential to cause considerable morbidity. Direct intra-operative monitoring of the eye may alert the surgeon to potential complications at an early stage. We describe the use of Steri-strips during endoscopic sinus surgery as an aid to monitoring for ocular complications during surgery. This is a cheap, simple and effective method of intra-operative monitoring.
We report two unusual and contrasting cases of Wegener's granulomatosis involving the orbit, requiring urgent endoscopic orbital decompression surgery.
Case series:
Both patients presented with an acute deterioration in visual function which failed to improve with medical management. Case one presented with systemic features of the condition, in contrast with case two, who presented with a more localised form of the disease. Whereas case one exhibited primary orbital disease with maxillary sinus extension (i.e. focal disease), case two illustrates orbital involvement secondary to sinus disease extension (i.e. contiguous disease). Prompt diagnosis, assisted by the presence of systemic features, led to a good visual outcome in case one. In case two, in which diagnosis was difficult and surgery delayed, the outcome was poor.
Conclusions:
These cases of orbital Wegener's granulomatosis illustrate the diagnostic challenge, the requirement for early intervention following acute visual deterioration and the importance of heightened awareness of the rarer ENT manifestations of this disease.