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Alzheimer’s disease (AD) drug development is a complex process that proceeds from identification of a biological target; to testing of candidate therapies in in vitro assays; assessment of efficacy in animal models and assessment of safety in several animal species; clinical testing in humans in Phase1, Phase 2, and Phase 3 clinical trials; regulatory review by agencies in all countries in which the drug might be marketed; and eventual commercialization. This process requires more than a decade to accomplish. The process involves substantial infrastructure resources; multiple stakeholders; and funding from a variety sources along the developmental pathway. This is the complex ecosystem that supports AD drug development.
This chapter focuses on shelters and their significance for providing protection for living things from environmental factors such as seasonal weather changes, natural disasters, extreme weather events and climate change. An ecosystem is the name given to a group of interacting organisms in a particular environment – which could be a city street, a creek in dense bushland or a coral reef. The world contains a huge variety of ecosystems where living things interact and often compete for available resources such as water, air, light, food, space and the resources required to provide shelters. This chapter examines the notion of community and the physical shelters that organisms require for long-term survival. It presents common examples of shelters created by humans and other animals, and describes three integrated STEM projects designed for Australian primary school classrooms.
The concepts of peace and peacebuilding were basically developed by men, often with a realist background. This top-down approach has people as simple spectators. Only an engendered-sustainable peace will be able to deal with the present global environmental and climate change. "Engendered-sustainable peace" refers to the structural factors related to long-term violence, deeply embedded in the patriarchal system and characterized by authoritarianism, discrimination, exploitation, destruction, and violence. I define and address the cosmopolitan concept of "engendered-sustainable peace" and examine its foundations in theories of positive, structural, cultural, and sustainable peace. I then address power relations from realism to cosmopolitanism, including historical materialism and feminist understandings. I then discuss the potential of technology for peacebuilding and examine how a transition toward an "engendered-sustainable peace" opens an analytical tool that could be used by bottom-up efforts to overcome the present violence against women, men, children, and elders, including the environment and ecosystem services.
Here, I outline the various sources of energy that different life-forms use. The most fundamental division of life from an energy perspective is that between self-feeders that can utilize non-biological forms of energy such as light (autotrophs) and those that feed on other organisms (heterotrophs). Further subdivision of the autotroph category shows that not all of these organisms conduct what can be called ordinary photosynthesis – the type that yields oxygen. Some autotrophs conduct non-oxygenic photosynthesis, while others do not use light at all, but rather utilize chemical energy of various kinds in processes that are collectively called chemosynthesis. Next, I consider the flow of energy in ecosystems and note the limitations in the efficiency of energy transfer between trophic levels, but also the limitations of the trophic-level concept itself. Finally, I note that the biosphere is a realm of decreasing entropy: processes that contribute to this decrease include evolution, embryological development, and ecological succession. The decreasing entropy of the biosphere is perfectly compatible with the second law of thermodynamics as this law only applies to closed systems.
This chapter introduces the reader to the volume and outlines the book’s structure: first, an overview of essential issues pertaining to dictionary style and content; secondly, a fresh narrative of the development of English dictionaries throughout the centuries right up to current-day applications of technology, corpus linguistics, natural language processing, machine learning, and artificial intelligence; and thirdly, essays on the regional and global nature of English lexicography and its power to help standardise varieties of English and to define nations seeking independence from the British Empire.
This chapter gives an overview of the traditions of English lexicography from the early modern period to the present day. Rather than presenting a linear story of evolutionary development, it surveys changes in the whole ecosystem of lexicographical publishing, from the most elementary spelling-books to the most scholarly multi-volume dictionaries, emphasising the books which came into the hands of the most readers: these were of course the smallest and cheapest. It is therefore attentive to changes in publishing technology (from handpress to machine press to digital) and to information about dictionaries as material books, such as physical size, number of editions, and size of print runs.
In this chapter, we focus on the role that innovation plays in the medtech ecosystem, including how innovation is financed by early-stage venture capital investors and valued by other stakeholders in the ecosystem. Using specific case studies and empirical data, we review the impact that innovation has on medical device companies’ revenue growth through market expansion and derivative product sales, and the ways in which medical device companies are valued by early-stage venture capital investors, public market investors, and strategic acquirers. In addition, there is a focus on the types of medtech product and service innovations that have driven the greatest value in the market, and the process of developing new technologies from ideation and invention to clinical evidence generation and regulatory approval, and then all of the way to widespread market adoption.
The public debate about smart contracts, meant as self-help remedies grounded on distributed ledger technology, is filled with alarms and high expectations. They have been praised by the tech community as infallible software able to carry out the whole contractual cycle, from formation to enforcement. Conversely, several legal scholars have raised concerns regarding both smart contracts’ inability to reflect relational aspects of contract governance and the augmented complexity generated by the translation of an agreement into computer code. The chapter focuses the discussion on the potential areas which could effectively benefit from implementation of smart contracts. Firstly, it argues that smart contracts might be a viable tool to tackle effectively consumers’ inertia in triggering and enforcing their rights which are standardized and easily verifiable. Secondly, smart contracts have the potential to foster commercial relationships by lowering down transaction costs arising from lack of trust between merchants. Thus, smart contracts are likely to provide better alternatives to traditional tools of business practice, such as letters of credit and escrow agreements.
The rocky shores of the north-east Atlantic have been long studied. Our focus is from Gibraltar to Norway plus the Azores and Iceland. Phylogeographic processes shape biogeographic patterns of biodiversity. Long-term and broadscale studies have shown the responses of biota to past climate fluctuations and more recent anthropogenic climate change. Inter- and intra-specific species interactions along sharp local environmental gradients shape distributions and community structure and hence ecosystem functioning. Shifts in domination by fucoids in shelter to barnacles/mussels in exposure are mediated by grazing by patellid limpets. Further south fucoids become increasingly rare, with species disappearing or restricted to estuarine refuges, caused by greater desiccation and grazing pressure. Mesoscale processes influence bottom-up nutrient forcing and larval supply, hence affecting species abundance and distribution, and can be proximate factors setting range edges (e.g., the English Channel, the Iberian Peninsula). Impacts of invasive non-native species are reviewed. Knowledge gaps such as the work on rockpools and host–parasite dynamics are also outlined.
The Arctic is warming faster than anywhere else of comparable size on Earth, impacting global climate feedbacks and the Arctic biota. However, a warm Arctic is not novel. The Late Cretaceous fossil record of the region enables a detailed reconstruction of polar environmental conditions, and a thriving extinct ecosystem, during a previous 'hothouse’ global climate. Using leaf form (physiognomy) and tree ring characteristics we reconstruct Cenomanian to Coniacian polar thermal and hydrological regimes over an average annual cycle at eight locations in NE Russia and northern Alaska. A new high spatial resolution (∼1 km) WorldClim2 calibration of the Climate Leaf Analysis Multivariate Program (CLAMP) yields results similar to, but often slightly warmer than, previous analyses, but also provides more detailed insights into the hydrological regime through the return of annual and seasonal vapour pressure deficit (VPD), potential evapotranspiration (PET) estimates and soil moisture, as well as new thermal overviews through measures of thermicity and growing degree days. The new results confirm the overall warmth of the region, particularly close to the Arctic Ocean, but reveal strong local differences that may be related to palaeoelevation in the Okhotsk–Chukotka Volcanogenic Belt in NE Russia. While rainfall estimates have large uncertainties due to year-round wet soils in most locations, new measures of VPD and PET show persistent high humidity, but with notably drier summers at all the Arctic sites.
Coho salmon (Oncorhynchus kisutch), Chinook salmon (Oncorhynchus tshawytscha) and steelhead (Oncorhynchus mykiss) in Puget Sound and the Strait of Georgia have exhibited declines in marine survival over the last 40 years. While the cause of these declines is unknown, multiple factors, acting cumulatively or synergistically, have likely contributed. To evaluate the potential contribution of a broad suite of drivers on salmon survival, we used qualitative network modelling (QNM). QNM is a conceptually based tool that uses networks with specified relationships between the variables. In a simulation framework, linkages are weighted and then the models are subjected to user-specified perturbations. Our network had 33 variables, including: environmental and oceanographic drivers (e.g., temperature and precipitation), primary production variables, food web components from zooplankton to predators and anthropogenic impacts (e.g., habitat loss and hatcheries). We included salmon traits (survival, abundance, residence time, fitness and size) as response variables. We invoked perturbations to each node and to suites of drivers and evaluated the responses of these variables. The model showed that anthropogenic impacts resulted in the strongest negative responses in salmon survival and abundance. Additionally, feedbacks through the food web were strong, beginning with primary production, suggesting that several food web variables may be important in mediating effects on salmon survival within the system. With this model, we were able to compare the relative influence of multiple drivers on salmon survival.
Governmental development strategies focus on entrepreneurship as a major resource for the economic development of indigenous peoples. While initiatives and programs are locally based, there is a debate in the academic literature about how contextual factors affect the identification of indigenous entrepreneurship. The purpose of this paper is to analyze and integrate indigenous entrepreneurship literature to identify the main indigenous entrepreneurship models. Thus, a systematic literature review was conducted. In total, 25 relevant articles were identified in selected electronic databases and manual searches of Australian Business Deans Council ranked journals from January 1, 1995 to the end of 2016. Using a systematic analysis of sociocultural contexts and locations, the paper proposed that a typology of contextualized indigenous entrepreneurship models was possible, that were classified as urban, remote and rural. The parameters of these models, and their potential theoretical and practical applications to the study and practice of indigenous entrepreneurship ecosystems were also outlined.
‘Innovation’ has become a buzzword in academic papers, news articles, and book titles, but it is variously defined and is often referred to as ‘invention’ or ‘design’. A consensus of understanding the interrelationships of the concepts and activities pertaining to innovation is needed to guide collective action for innovation. This paper proposes a united view of the innovation process, which advocates uniting the complementary (1) science, (2) design, and (3) entrepreneurship sub-processes of innovation. The shared creative, uncertain, and costly nature of these three processes also implies an opportunity to leverage design science to understand and guide the science and entrepreneurship processes. This paper describes the benefits, major challenges, and actionable strategies for uniting science, design, and entrepreneurship as sub-processes of innovation, with a few detailed real life examples. The variety of the cases and examples shows that science, design, and entrepreneurship sub-processes can be effectively united to different extents, within and across organizations and innovation ecosystems.
Biodiversity is an abstract concept, attracting various responses from different people according to where they have come from and what ecosystems they have been closely linked to. In theory, most people would agree that protecting biodiversity is an important process, but in practice, few people commit to actions on a local level. This paper explores a situation faced in the Northern Territory where environmental educators seek to engage hearts, hands and minds to protect biodiversity but it is difficult to gain commitment given a diverse and transient community such as exists in Darwin. The survey of 175 tertiary students at Charles Darwin University develops insights into how individuals perceive and name local mangrove and savanna ecosystems, and which areas they would want to conserve. Results have implications for local environmental education. Suggestions are made about how awareness of and actions for biodiversity in the Top End could be extended.
This article examines postcolonial representations of the jungle and the desert, focusing on two novels in particular: Étienne Goyémidé’s Le silence de la forêt (1984) and Tahar Djaout’s L’invention du désert (1987). Postcolonial literary representations of these “extreme” landscapes are layered with allusions and almost always engage in an intertextual conversation with the colonial genres that influenced readers’ conception of these spaces. The specificity of jungle and desert serves in contemporary postcolonial literature as a foil to homogenizing forces of both the past and the present, as seen in the stylistic techniques authors employ to depict these spaces. These stylistic techniques often work in two seemingly opposing directions: they “naturalize” landscapes that are often portrayed as inhuman and contrast them to the “unnatural” structures of colonial and postcolonial society, while at the same time embodying and claiming the distortion or disorientation inherent in those landscapes. These complex, multifaceted, geographically rooted descriptions, which incorporate and react to a variety of historical and cultural factors, take what I call an ecosystem approach, rather than continuing to rely on a false nature/culture division.
Several recent papers have criticized the scientific robustness of the fisheries management system used by the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR), including that for Ross Sea toothfish. Here we present a response from the wider CCAMLR community to address concerns and to correct some apparent misconceptions about how CCAMLR acts to promote conservation whilst allowing safe exploitation in all of its fisheries. A key aspect of CCAMLR’s approach is its adaptive feedback nature; regular monitoring and analysis allows for adjustments to be made, as necessary, to provide a robust management system despite the statistical uncertainties inherent in any single assessment. Within the Ross Sea, application of CCAMLR’s precautionary approach has allowed the toothfish fishery to develop in a steady fashion with an associated accumulation of data and greater scientific understanding. Regular stock assessments of the fishery have been carried out since 2005, and the 2013 stock assessment estimated current spawning stock biomass to be at 75% of the pre-exploitation level. There will always be additional uncertainties which need to be addressed, but where information is lacking the CCAMLR approach to management ensures exploitation rates are at a level commensurate with a precautionary approach.
There is significant concern about potential ecological effects of introduced organisms, including non-indigenous species and those created by genetic modification. This paper presents an Ecopath with Ecosim modelling approach, designed to examine long-term trophic effects of growth hormone (GH) transgenic coho salmon should they ever escape to a coastal salmonid ecosystem, namely the Strait of Georgia in British Columbia (Canada). The model showed that the effects of introduced GH transgenic coho salmon varied with their biomass, diet, structure of the invaded ecosystem, and environmental conditions. Occasional escapes of non-reproductive salmon did not have a significant impact on the example ecosystem. However, effects of GH coho salmon varied with their diet when large numbers of these fish were present in the simulated ecosystem (for example, when they constituted 20% of total current aquaculture production in the area). Further, climate-driven changes in the biomass of low trophic levels (bottom-up effects) could have a greater impact on the ecosystem than the introduction of large numbers of GH coho salmon. A new version of Ecopath with Ecosim's Monte Carlo approach showed that the model predictions were robust to GH coho salmon's Ecopath parameters, but more sensitive to vulnerabilities of prey to GH coho salmon. Modelling ecosystem effects of genetically modified organisms provides a complementary approach for risk assessments when data from nature are not readily obtainable.
With a rich mix of theatrical material to bring to the table, the climate-change debate playing out in the public domain would seem well adapted to the stage, and has often been presented in docu-dramatic form, as in Al Gore's well-known film An Inconvenient Truth. But until relatively recently climate change and the science relating to it have been conspicuous by their absence from the stage. Early movers on the climate-change theatre scene included Caryl Churchill's 2006 climate-change libretto for the London Proms, We Turned on the Light, and John Godber's 2007 play Crown Prince. Since then, interest has steadily increased. In 2009 came Steve Waters's double bill The Contingency Plan (On the Beach and Resilience). This was quickly followed by Earthquakes in London by Mike Bartlett in 2010, and by three further plays in the spring of 2011: Greenland, the collaborative work of Moira Buffini, Matt Charman, Penelope Skinner, and Jack Thorne; The Heretic by Richard Bean; and Wastwater by Simon Stephens. In this article Julie Hudson focuses on three of these works to explore how the plays engage with the debate through the medium of climate-change science. As her article suggests, these British climate-change plays make an important and occasionally subversive contribution to the long-running discourse on the relationship between science, the ecosystem, and human beings. In performance, they succeed in turning a subject that has been overplayed for effect in the public domain into compelling theatre. Julie Hudson is currently a visiting fellow at the Smith School of Enterprise and the Environment, Oxford University.
Using archival photography and satellite imagery, we have analysed the rates of advance or retreat of 103 coastal glaciers on South Georgia from the 1950s to the present. Ninety-seven percent of these glaciers have retreated over the period for which observations are available. The average rate of retreat has increased from 8 Ma-1 in the 1950s to 35 Ma-1 at present. The largest retreats have all taken place along the north-east coast, where retreat rates have increased to an average of 60 Ma-1 at present, but those on the south-west coast have also been steadily retreating since the 1950s. These data, along with environmental information about South Georgia, are included in a new Geographic Information System (GIS) of the island. By combining glacier change data with the present distribution of both endemic and invasive species we have identified areas where there is an increased risk of rat invasion to unoccupied coastal regions that are currently protected by glacial barriers. This risk has significant implications for the surrounding ecosystem, in particular depletion in numbers of important breeding populations of ground-nesting birds on the island.