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Traditional naming tests are unsuitable to assess naming impairment in diverse populations, given the influence of culture, language, and education on naming performance. Our goal was therefore to develop and validate a new test to assess naming impairment in diverse populations: the Naming Assessment in Multicultural Europe (NAME).
Method:
We carried out a multistage pilot study. First, we generated a list of 149 potentially suitable items – e.g. from published cross-linguistic word lists and other naming tests – and selected those with a homogeneous age of acquisition and word frequency across languages. We selected three to four colored photographs for each of the 73 remaining items; 194 controls selected the most suitable photographs. Thirteen items were removed after a pilot study in 15 diverse healthy controls. The final 60-item test was validated in 39 controls and 137 diverse memory clinic patients with subjective cognitive impairment, neurological/neurodegenerative disease or psychiatric disorders in the Netherlands and Turkey (mean age: 67, SD: 11). Patients were from 15 different countries; the majority completed primary education or less (53%).
Results:
The NAME showed excellent reliability (Spearman–Brown coefficient: 0.95; Kuder–Richardson coefficient: 0.94) and robust correlations with other language tests (ρ = .35–.73). Patients with AD/mixed dementia obtained lower scores on most (48/60) NAME items, with an area under the curve of 0.88. NAME scores were correlated with age and education, but not with acculturation or sex.
Conclusions:
The NAME is a promising tool to assess naming impairment in culturally, educationally, and linguistically diverse individuals.
This chapter investigates whether sentence comprehension difficulty in aphasia can be explained in terms of retrieval processes. By modelling individuals with aphasia (IWAs) separately, we show that different IWAs show impairments along different dimensions: slowed processing, intermittent deficiency, and resource reduction. The parameters in the cue-based retrieval model have a theoretical interpretation that allows these three theories to be implemented within the architecture. In a further investigation, we compare the relative predictive accuracy of the cue-based model with that of the direct-access model. The benchmark data here are from Caplan et al. (2015); k-fold cross-validation is used as in the preceding chapter. The cue-based retrieval model is shown to have a better predictive performance.
Chapter 8 describes the fundamental research questions, empirical approaches and findings of neurolinguistics. It is a highly interdisciplinary linguistic subfield focusing on the relationship between brain and language behaviour. Concentrating on experimental research, methodological issues include considerations on research participants, data types, and techniques of data acquisition and analysis. The chapter ends with recommendations for further reading and a list of short exercises and ideas for small research projects.
In this chapter we consider more closely what we mean by a word. We begin by contrasting the differences between the mental lexicon and dictionaries. We then introduce students to the methods and techniques that psycholinguists use for studying the mental lexicon. We look at reaction time experiments, brain imaging, and the ways in which we can study individuals with aphasia and genetic disorders that affect lexical knowledge. Students are introduced to how children acquire morphology. We then look at English past tense morphology in the context of the ‘storage versus rules’ debate, considering what experimentation, brain imaging, and the study of aphasia and genetic disorders tell us about this controversy. The chapter ends with a brief history of dictionaries.
Much research has been dedicated to the effects of bilingualism on executive control (EC). For bilinguals with aphasia, the interplay with EC is complex. In this systematic review, we synthesize research on this topic and provide an overview of the current state of the field. First, we examine the evidence for EC deficits in bilingual persons with aphasia (bPWA). We then discuss the domain generality of bilingual language control impairments. Finally, we evaluate the bilingual advantage hypothesis in bPWA. We conclude that (1) EC impairments in bPWA are frequently observed, (2) experimental results on the relationship between linguistic and domain-general control are mixed, (3) bPWA with language control problems in everyday communication have domain-general EC problems, and (4) there are indications for EC advantages in bPWA. We end with directions for experimental work that could provide better insight into the intricate relationship between EC and bilingual aphasia.
This article aims to expose the political and cultural processes that contributed to the eradication of problematic memories of the Italian colonial period during the national reconstruction following the Second World War. It offers a systematic examination of newsreels and documentaries about the Italian former colonies that were produced between 1946 and 1960, a film corpus that has largely been neglected by previous scholarship. The article first dissects the ambiguous political scenario that characterised the production of this footage through the study of original archival findings. The footage configured a particular form of self-exculpatory memory, which obstructed a thorough critique of the colonial period while articulating a new discourse about the future presence of Italy in the former colonies. This seems to be a case of aphasia rather than amnesia, insofar as the films addressed not an absence, but an inability to comprehend and articulate a critical discourse about the past. This aphasic configuration of colonial memories will be tackled through a close reading of the voice-over and commentary. In so doing, this work suggests that the footage actively contributed to spread un-problematised narratives and memories about the colonial period, whose results still infiltrate Italian contemporary society, politics and culture.
In the present study, we explored numerical problems in individuals with aphasia. We investigate whether numerical deficits, usually accompanying aphasia, can be observed on number comprehension tasks that do not necessarily require an oral response.
Method:
Individuals with aphasia were classified into anterior, posterior, and global subgroups according to the lesion type. To investigate numerical cognition, we used a relatively recent tool, the Numerical Activities of Daily Living (NADL).
Results:
The results showed that individuals with aphasia have problems with tasks of basic number comprehension as well as in most NADL. In the formal part of the NADL, anterior aphasic patients made comparatively more errors than the posterior aphasic patients. Global aphasic patients presented an invariably poor performance on almost all tasks.
Conclusion:
The results provide insight into how numerical deficits may impair an individual with aphasia in activities of daily living. This study is a preliminary attempt to start the validation process of the NADL for the Greek population.
Chapter 15 looks at the brain’s anatomy in terms of the areas important for language. It shows that, typically, the left hemisphere is widely responsible for language competence and performance. Readers learn about common methods and technologies used to study the brain, including lesion studies and autopsies, dichotic listening and split-brain studies, neuroimaging, and studies measuring the brain’s electric and magnetic fields. These methods have provided an incredible advantage to better understanding brain and language. This is especially apparent regarding language impairments that result from acquired brain damage or injury (either instantaneous or progressive). Some impairments discussed in the chapter include forms of aphasia: non-fluent, fluent, and primary progressive along with language disturbances primarily related to reading (e.g., alexia) and writing (e.g., agraphia) abilities. Finally, the chapter discusses how neurolinguistics informs what we know about the mental lexicon—words, their sounds, and meanings—along with morphology and syntax. Research using state-of-the-art technologies has informed us about which language functions rely on which brain structures.
Non-invasive brain stimulation to stimulate neuroplasticity, enhance recovery, and improve mood after stroke has made substantial technical advances in the past two decades. The most common neuromodulatory techniques are transcranial direct current stimulation (tDCS), applying a weak electrical current across the brain, and transcranial magnetic stimulation (TMS), inducing an electrical field within the brain. Currently, the only non-invasive brain stimulation technique and indication for which there is a sufficiently strong evidence base to support routine use in clinical practice is transcranial magnetic stimulation to improve mood in post-stroke depression. TMS applied to dorsolateral prefrontal cortices can substantially reduce depressive symptoms, though not increase complete remission. TMS is a reasonable second-line intervention in patients with post-stroke depressed mood who have been resistant to pharmacotherapy. For several additional indications in post-stroke patients, both TMS and tDCS have shown signals of potential benefit in randomized trials. The strongest evidence is for enhancement of recovery of upper extremity motor function and hand dexterity with TMS. In addition, there is suggestive evidence for possible benefit in improving recovery of function after stroke in walking (TMS), activities of daily living (tDCS), aphasia (both), hemispatial neglect (both), and swallowing (both). However, for these and potentially other recovery-enhancing applications, substantial additional larger trials are needed.
Language and cognitive impairments are common consequences of stroke. These difficulties persist with 60% of stroke survivors continuing to experience memory problems, 50% attention deficits and 61% communication problems long after the onset of the stroke-related impairments. Such deficits are ‘invisible’ – evident only through patient report, behavioural observation or formal assessment. The impacts of such deficits are considerable and can include prolonged hospital stays, poorer functional recovery and reduced quality of life. Effective and timely rehabilitation of language (auditory comprehension, expressive language, reading and writing) and cognitive abilities (memory, attention, spatial awareness, perception and executive function) are crucial to optimise recovery after stroke. In this chapter we review the current evidence base, relevant clinical guidelines relating to language and cognitive impairments and consider the implications for stroke rehabilitation practice and future research. Speech and language therapy offers benefit to people with aphasia after stroke; intensive intervention, if tolerated, likely augments the benefits. Interventions for deficits in all non-language cognitive domains exist, but need refining and evaluating more thoroughly with a wider range of methodologies.
Repetitive transcranial magnetic stimulation (rTMS) applied over brain regions responsible for language processing is used to curtail potentially auditory hallucinations in schizophrenia patients and to investigate the functional organisation of language-related areas. Variability of effects is, however, marked across studies and between subjects. Furthermore, the mechanisms of action of rTMS are poorly understood.
Here, we reviewed different factors related to the structural and functional organisation of the brain that might influence rTMS-induced effects. Then, by analogy with aphasia studies, and the plastic-adaptive changes in both the left and right hemispheres following aphasia recovery, a hypothesis is proposed about rTMS mechanisms over language-related areas (e.g. Wernicke, Broca). We proposed that the local interference induced by rTMS in language-related areas might be analogous to aphasic stroke and might lead to a functional reorganisation in areas connected to the virtual lesion for language recovery.
Group treatment enables people with aphasia to practise communication skills outside the typical clinician–patient dyad. While there is evidence that this treatment format can improve participation in everyday communication, there is little evidence it impacts linguistic abilities. This project aimed to investigate the effects of ‘typical’ group treatment on the communication skills of people with aphasia with a focus on word retrieval in discourse.
Methods:
Three people with aphasia took part in a 6-week group therapy programme. Each week focused on a different topic, and three topics also received a home programme targeting word retrieval. The six treated topics were compared with two control topics, with regard to language production in connected speech. Semistructured interviews were collected twice prior to treatment and twice following the treatment and analysed using (a) word counts; (b) the profile of word errors and retrieval in speech; (c) a measure of propositional idea density, and (d) perceptual discourse ratings.
Results:
Two participants showed no significant improvements; one participant showed significant improvement on discourse ratings.
Conclusions:
This study provides limited support for group treatment, leading to improved communication as measured by semistructured interviews, even when supplemented with a home programme. We suggest that either group treatment, as implemented here, was not an effective approach for improving communication for our participants and/or that outcome measurement was limited by difficulty assessing changes in connected speech.
Inflection impairments are commonly noted in aphasia, particularly non-fluent variants, where descriptions of such difficulties often focus on inflection omission. This aligns with rule-based theory, in which inflected forms should be more difficult to produce than their uninflected counterparts. Recent studies address noun inflection for number and potential effects of the relative frequency of singular and plural forms (dominance effects). However, none examine number errors qualitatively or in spontaneous speech. We present quantitative and qualitative analyses of such errors in nouns produced by twelve people with aphasia in spoken Cinderella narratives, examining: error rate; error types and nouns involved; relationship between error production and dominance; and speakers’ consistency with error production and flexibility in varying the noun forms concerned. Twelve unimpaired speakers provide comparison data. While error rates were low, arguably more important is error type. Singularisation and pluralisation errors were observed, all on regular nouns and involving production of the dominant form. The pluralisation errors, all occurring on references to Cinderella’s glass slipper, arguably challenge rule-based predictions that the singular is easier to retrieve than the plural. We suggest constructivist, usage-based theory as a promising framework to characterise such productions. Implications for aphasiology and clinical practice are also discussed.
Objective: The Boston Diagnostic Aphasia Examination (BDAE) is one of the most commonly used aphasia batteries. The newest edition has undergone significant revisions since its original publication in 1972, but existing evidence for its validity is lacking. We examined the construct validity of BDAE-3 and identified the factor structure of this battery. Method: A total of 355 people with aphasia of various types and severity completed neuropsychological evaluations to assess their patterns of language impairment. A principal component analysis with varimax rotation was conducted to examine the components of BDAE-3 subtests. Results: Five components accounting for over 70% of the BDAE-3 total variance were found. The five language factors identified were auditory comprehension/ideomotor praxis, naming and reading, articulation-repetition, grammatical comprehension, and phonological processing. Conclusions: Our results show that the BDAE-3 demonstrates good construct validity, and certain language functions remain primary, distinct language domains (i.e., receptive vs. expressive language) across severities of aphasia. Overall, our findings inform clinical practice by outlining the inherent structure of language abilities in people with aphasia. Clinicians can utilize the findings to select core BDAE-3 tests that are most representative of their respective functions, thereby reducing the total testing time while preserving diagnostic sensitivity. (JINS, 2019, 25, 772–776)
Background/Study Concept: Acute lacunar stroke (Als) plays a role in death/disability worldwide. Aphasia refers to chronic difficulty with communication in >20% of patients post stroke. We describe pathophysiological features of white matter (WM) abnormalities and their relationship between WM changes and aphasia quotient (AQ) scores in Als.
Methods: Diffusion tensor imaging data were acquired in 37 Als patients and 28 healthy controls. Tract-based spatial statistics (TBSS) and correlation analyses were used.
Results: Consistent with the hypothesis, Als had decreased fractional anisotropy (FA) and increased mean diffusivity, axial diffusivity and radial diffusivity in the genu, body and splenium of the corpus callosum (CC), superior longitudinal fasciculus (SLF) and corona radiata in the bilateral hemisphere. Reduced FA of SLF was correlated with AQ scores in Als patients.
Conclusion: It is hoped that TBSS could shed new insights into aphasia mechanisms in Als to help promote aging-related disease studies.
In this study we examined linguistic and non-linguistic control mechanisms in 20 Spanish–English neurologically healthy bilingual adults and 13 Spanish–English bilingual adults with aphasia. Participants completed two linguistic and two non-linguistic control tasks accounting for low and high complexity. Healthy bilingual results were indicative of domain general cognitive control, whereas patient results were indicative of domain specific cognitive control. The magnitude of conflict required to complete the tasks was also examined. Healthy bilinguals exhibited significant amounts of conflict on all tasks and linguistic and non-linguistic conflict ratios were correlated; whereas patient results revealed significant conflict only on non-linguistic tasks and those conflict ratios were not correlated with linguistic conflict ratios, indicating a dissociation between how patients are controlling information in these two domains. Finally, a relationship between language impairment and language control was identified and brain damage was associated with linguistic and non-linguistic task performance.
Studies of language disorders have shaped our understanding of brain–language relationships over the last two centuries. This article provides a review of this research and how our thinking has changed over the years regarding how the brain processes language. In the 19th century, a series of famous case studies linked distinct speech and language functions to specific portions of the left hemisphere of the brain, regions that later came to be known as Broca’s and Wernicke’s areas. One hundred years later, the emergence of new brain imaging tools allowed for the visualization of brain injuries in vivo that ushered in a new era of brain-behavior research and greatly expanded our understanding of the neural processes of language. Toward the end of the 20th century, sophisticated neuroimaging approaches allowed for the visualization of both structural and functional brain activity associated with language processing in both healthy individuals and in those with language disturbance. More recently, language is thought to be mediated by a much broader expanse of neural networks that covers a large number of cortical and subcortical regions and their interconnecting fiber pathways. Injury to both grey and white matter has been seen to affect the complexities of language in unique ways that have altered how we think about brain–language relationships. The findings that support this paradigm shift are described here along with the methodologies that helped to discover them, with some final thoughts on future directions, techniques, and treatment interventions for those with communication impairments. (JINS, 2017, 23, 741–754)
Primary progressive aphasia (PPA) affects a range of language and cognitive domains that impact on conversation. Little is known about conversation breakdown in the semantic variant of PPA (svPPA, also known as semantic dementia). This study investigates conversation of people with svPPA.
Methods:
Dyadic conversations about everyday activities between seven individuals with svPPA and their partners, and seven control pairs were video recorded and transcribed. Number of words, turns, and length of turns were measured. Trouble-indicating behaviors (TIBs) and repair behaviors were categorized and identified as successful or not for each participant in each dyad.
Results:
In general, individuals with svPPA were active participants in conversation, taking an equal proportion of turns, but indicating a great deal of more trouble in conversation, shown by the significantly higher number of TIBs than evidenced by partners or control participants. TIBs were interactive (asking for confirmation with a shorter repetition of the original utterance or a repetition which included a request for specific information) and non-interactive (such as failing to take up or continue the topic or a minimal response) and unlike those previously reported for people with other PPA variants and dementia of the Alzheimer type. Communication behaviors of the partner were critical to conversational success.
Conclusions:
Examination of trouble and repair in 10-min conversations of individuals with svPPA and their important communication partners has potential to inform speech pathology interventions to enhance successful conversation, in svPPA and should be an integral part of the comprehensive care plan.