Studies were conducted to determine the usefulness of HOE-39866 (HOE-00661) in chemical fallow systems on the Canadian prairies. HOE-39866 at 0.5 to 1.0 kg ai/ha controlled Russian thistle, kochia, green foxtail, wild oats, and wheat comparable to paraquat, glyphosate, and glyphosate plus the isopropylamine salt of 2,4-D. However, control of barley with HOE-39866 was unacceptable. HOE-39866 was compatible in tank mixtures with ammonium sulfate, paraquat, chlorsulfuron, and metsulfuron. Ammonium sulfate improved weed control when HOE-39866 was applied at 0.25 kg/ha but not at 0.75 kg/ha. Adding paraquat at 0.07 to 0.21 kg ai/ha to HOE-39866 improved control of grass species over HOE-39866 alone. Adding chlorsulfuron and metsulfuron to HOE-39866 provided greater initial control of certain species as well as residual control of many weeds. HOE-39866 alone or in conjunction with other herbicides is an alternative to the herbicides used in chemical fallow systems.