A glasshouse study was established at Louisiana State University campus in Baton Rouge, LA, to evaluate the control of fall panicum and Nealley’s sprangletop treated with florpyrauxifen-benzyl. Florpyrauxifen was applied at 30 g ai ha–1 to each grass species at the three- to four-leaf and one- to two-tiller stages of growth. At 21 d after treatment (DAT), fall panicum control was 91% when treated with florpyrauxifen at the three- to four-leaf stage, and Nealley’s sprangletop control was 78% to 82%, regardless of application timing 21 DAT. Leaf number, tiller number, plant height, and plant fresh weight were reduced when fall panicum and Nealley’s sprangletop were treated with florpyrauxifen. This information can be useful for developing weed management strategies with this herbicide for rice production, and it provides an additional mode of action to help manage and/or delay the development of herbicide-resistant weeds.