The self-generated magnetic field in three-dimensional (3-D) single-mode ablative Rayleigh–Taylor instability (ARTI) relevant to the acceleration phase of a direct-drive inertial confinement fusion (ICF) implosion is investigated. It is found that stronger magnetic fields up to a few thousand teslas can be generated by 3-D ARTI rather than by its two-dimensional (2-D) counterpart. The Nernst effects significantly alter the magnetic field convection and amplify the magnetic fields. The magnetic field of thousands of teslas yields the Hall parameter of the order of unity, leading to profound magnetized heat flux modification. While the magnetic field significantly accelerates the bubble growth in the short-wavelength 2-D modes through modifying the heat fluxes, the magnetic field mostly accelerates the spike growth but has little influence on the bubble growth in 3-D ARTI. The accelerated growth of spikes in 3-D ARTI is expected to enhance material mixing and degrade ICF implosion performance. This work is focused on a regime relevant to direct-drive ICF parameters at the National Ignition Facility, and it also covers a range of key parameters that are relevant to other ICF designs and hydrodynamic/astrophysical scenarios.

The incidence of obesity related glomerulopathy (ORG) is rising worldwide with very limited treatment methods. Paralleled with the gut-kidney axis theory, beneficial effects of butyrate, one of short-chain fatty acids produced by gut microbiota, on metabolism and certain kidney diseases have gained growing attention. However, the effects of butyrate on ORG and its underlying mechanism are largely unexplored. In this study, a mice model of ORG was established with high-fat diet (HFD) feeding for 16 weeks, and sodium butyrate treatment was initiated at the 8th week. Podocytes injury, oxidative stress, and mitochondria function were evaluated in mice kidney and validated in vitro in palmitic acid (PA) treated-MPC5 cells. Further, the molecular mechanisms of butyrate on podocytes were explored. Compared with controls, sodium butyrate treatment alleviated kidney injuries and renal oxidative stress in HFD-fed mice. In MPC5 cells, butyrate ameliorated PA-induced podocyte damage and helped maintain the structure and function of the mitochondria. Moreover, the effects of butyrate on podocytes were mediated via GPR43-Sirt3 signal pathway, as evidenced by the diminished effects of butyrate with the intervention of GPR43 or Sirt3 inhibitors. In summary, we conclude that butyrate has therapeutic potential for the treatment of ORG. It attenuates HFD-induced ORG and podocytes injuries through the activation of GPR43-Sirt3 signaling pathway.

This study examined the sour grapes/sweet lemons rationalization through 2 conditions: ‘attainable’ (sweet lemons) and ‘unattainable’ (sour grapes), reflecting China’s 2019-nCoV vaccination strategy. The aim was to find ways to change people’s beliefs and preferences regarding vaccines by easing their safety concerns and encouraging more willingness to get vaccinated. An online survey was conducted from January 22 to 27, 2021, with 3,123 residents across 30 provinces and municipalities in the Chinese mainland. The direction of belief and preference changed in line with the sour grapes/sweet lemons rationalization. Using hypothetical and real contrasts, we compared those for whom the vaccine was relatively unattainable (‘sour grapes’ condition) with those who could get the vaccine easily (‘sweet lemons’). Whether the vaccine was attainable was determined in the early stage of the vaccine roll-out by membership in a select group of workers that was supposed to be vaccinated to the greatest extent possible, or, by being in the second stage when the vaccine was available to all. The attainable conditions demonstrated higher evaluation in vaccine safety, higher willingness to be vaccinated, and lower willingness to wait and see. Hence, we propose that the manipulation of vaccine attainability, which formed the basis of the application of sour grapes/sweet lemons rationalization, can be utilized as a means to manipulate the choice architecture to nudge individuals to ease vaccine safety concerns, reducing wait-and-see tendencies, and enhancing vaccination willingness. This approach can expedite universal vaccination and its associated benefits in future scenarios resembling the 2019-nCoV vaccine rollout.

This scoping review aimed to evaluate the effect of exercise combined with vitamin D supplementation on skeletal muscle health in older individuals. We implemented a systematic search of electronic databases, including PubMed, the Cochrane Library, Web of Science, and Embase, was conducted from the time of library construction to January 2024. Eligible studies were randomized controlled trials (RCTs) including men and women aged 65 years or mean age 65 years; exercise training and vitamin D supplementation; outcomes of muscular strength, function, muscular power, body composition, and quality of life; and results compared with those of exercise intervention alone. The results showed 13 studies including 1483 participants were identified. The proportions of male and female sex were 22.05% and 77.95%, respectively. Exercise intervention methods included resistance exercises and multimodal exercise training. All vitamin D interventions involved supplementation with vitamin D3. A significant increase was identified in short physical performance battery (SPPB) and stair climbing but not in skeletal muscle mass, skeletal strength, the timed up and go (TUG) test, and gait speed in older adults after exercise combined with vitamin D supplementation. In conclusion，exercise combined with vitamin D supplementation has additive health effects on SPPB and stair climbing. Furthermore, when vitamin D was deficient at baseline, the combined effect of exercise and vitamin D intervention significantly increased the TUG and gait speed in older adults. In future RCTs on this topic, baseline vitamin D nutritional status, health condition, and sex should be considered.

The disassembly of end-of-life lithium–ion batteries (EOL-LIBs) is inherently complex, owing to their multi-state and multi-type characteristics. To mitigate these challenges, a human–robot collaboration disassembly (HRCD) model is developed. This model capitalizes on the cognitive abilities of humans combined with the advanced automation capabilities of robots, thereby substantially improving the disassembly process’s flexibility and efficiency. Consequently, this method has become the benchmark for disassembling EOL-LIBs, given its enhanced ability to manage intricate and adaptable disassembly tasks. Furthermore, effective disassembly sequence planning (DSP) for components is crucial for guiding the entire disassembly process. Therefore, this research proposes an approach for the generation of HRCD sequences for EOL-LIBs based on knowledge graph, providing assistance to individuals lacking relevant knowledge to complete disassembly tasks. Firstly, a well-defined disassembly process knowledge graph integrates structural information from CAD models and disassembly operating procedure. Based on the acquired information, DSP is conducted to generate a disassembly sequence knowledge graph (DSKG), which serves as a repository in graphical form. Subsequently, knowledge graph matching is employed to align nodes in the existing DSKG, thereby reusing node sequence knowledge and completing the sequence information for the target disassembly task. Finally, the proposed method is validated using retired power LIBs as a case study product.

Perinatal malnutrition is a critical cause of diseases in offspring. Based on the different rates of organ development, we hypothesised that malnutrition at varying early life stages would have a differential impact on cardiovascular disease in middle-aged and older adults. This study sought to assess the long-term impact of exposure to the 1959–1961 Great Chinese Famine (GCF) during early developmental periods on risks of cardiovascular diseases in the late middle-aged offspring. A total 6, 662 individuals, born between 1958 and 1964, were divided into six groups according to the birth date. The generalised line model was used to control age and estimate differences with 95% confidence interval (CI) in blood pressure. Binary logistic regression was applied to evaluate the association between famine exposure and cardiovascular diseases. Compared to the unexposed late middle-aged persons, blood pressure was elevated in the entire gestation exposure group, regardless of postnatal exposure to GCF. Increased blood pressure was also found in the female offspring exposed to GCF during early and middle gestation. The early-childhood exposure was associated with the risk of bradycardia in the offspring. The risks of vertebral artery atherosclerosis were elevated in GCF famine-exposed groups except first trimester exposed group. The chronic influence of GCF in early life periods was specific to the developmental timing window, sexesand organs, suggesting an essential role of interactions among multiple factors and prenatal malnutrition in developmentally “programming” cardiovascular diseases.

Large amounts of small inertial particles embedded in a turbulent flow are known to modify the turbulent statistics and structures, a phenomenon referred to as turbulence modulation. While particle electrification is ubiquitous in particle-laden turbulence and significantly alters particle behaviour, the effects of inter-particle electrostatic forces on turbulence modulation and the underlying physical mechanisms remain unclear. To fill this gap, we perform a series of point-particle direct numerical simulations of turbulent channel flows at a friction Reynolds number of approximately 540, laden with uncharged and charged bidisperse particles. The results demonstrate that, compared to flows laden with uncharged particles, the presence of inter-particle electrostatic forces leads to substantial changes in both turbulent intensities and structures. In particular, the inner-scaled mean streamwise fluid velocity is found to shift towards lower values, indicating a noticeable increase in fluid friction velocity. Turbulent intensities appear to be further suppressed through facilitating the particles to extract momentum from the fluid phase and increasing extra turbulent kinetic dissipation by particles. Importantly, the overall drag is enhanced by indirectly strengthening the contribution of particle stress, even though the contribution of the total fluid stress is decreased. On the other hand, the magnitude of the large-scale motions is weakened by simultaneously reducing turbulent production and increasing particle feedback around the scales of the large-scale motions. Meanwhile, the average streaky fluid structures in the streamwise–spanwise planes and inclined fluid structures in the streamwise–wall-normal planes become expanded and flattened, respectively.

Spray formed by a myriad of secondary droplets generated by the impact of raindrops on a deep-water pool is studied with a laboratory rain facility. Experiments are performed with two rain rates and raindrops fall on the water surface at a nearly constant velocity. The secondary droplets at various heights above the pool's water surface are recorded with a cinematic digital in-line holographic technique that consists of a high-speed camera, a pulsed Nd:YLF laser and associated optics. The experimental results show that in the heat-map scatter plots of radius versus velocity near the water surface of the pool, the droplets are distributed into three regions, corresponding to distinct physical mechanisms of droplet generation. It is found that the diameter distribution of the droplets in the rain field changes with height above the pool's water surfaces. Both numerical simulation and experimental data reveal that the liquid water content, due to the presence of secondary droplets, in the atmospheric surface layer decreases exponentially with increasing height.

Intracytoplasmic sperm injection (ICSI) is a technique that directly injects a single sperm into the cytoplasm of mature oocytes. Here, we explored the safety of single-sperm cryopreservation applied in ICSI. This retrospective study enrolled 186 couples undergoing ICSI-assisted pregnancy. Subjects were allocated to the fresh sperm (group A)/single-sperm cryopreservation (group B) groups based on sperm type, with their clinical baseline/pathological data documented. We used ICSI-compliant sperm for subsequent in vitro fertilization and followed up on all subjects. The recovery rate/cryosurvival rate/sperm motility of both groups, the pregnancy/outcome of women receiving embryo transfer, and the delivery mode/neonatal-related information of women with successful deliveries were recorded. The clinical pregnancy rate, cumulative clinical pregnancy rate, abortion rate, ectopic pregnancy rate, premature delivery rate, live birth delivery rate, neonatal birth defect rate, and average birth weight were analyzed. The two groups showed no significant differences in age, body mass index, ovulation induction regimen, sex hormone [anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH)/luteinizing hormone (LH)] levels, or oocyte retrieval cycles. The sperm recovery rate (51.72%-100.00%) and resuscitation rate (62.09% ± 16.67%) in group B were higher; the sperm motility in the two groups demonstrated no significant difference and met the ICSI requirements. Group B exhibited an increased fertilization rate, decreased abortion rate, and increased safety versus group A. Compared with fresh sperm, the application of single-sperm cryopreservation in ICSI sensibly improved the fertilization rate and reduced the abortion rate, showing higher safety.