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Surveys of women transiting menopause at the usual age of 45 to 55 years overwhelmingly confirm that their greatest fear regarding hormone therapy (HT) is that of breast cancer. The expert panel concluded that although memory complaints are common in midlife, findings from well characterized cohorts suggest that natural menopause has little effect on memory performance or other areas of cognitive function. As basic mechanisms of brain cell metabolism and neural pathways are revealed, the possibility exists for specific ligand receptor products to be developed with planned and precisely targeted activity. This epilogue presents some closing thoughts on the concepts discussed in this book. The contents of this book reveal the exciting frontier of the new science of brain and memory research, and should act as a stimulus to basic science and clinical researchers going forward.