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3 results

  • The Effect of Aerobic Exercise on White Matter Hyperintensity Progression May Vary by Sex

  • Elizabeth Dao, Cindy K. Barha, John R. Best, Ging-Yuek Hsiung, Roger Tam, Teresa Liu-Ambrose
  • Journal:
    Canadian Journal on Aging / La Revue canadienne du vieillissement / Volume 38 / Issue 2 / June 2019
    Published online by Cambridge University Press:
    14 March 2019, pp. 236-244
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  • This study explored the efficacy of aerobic training (AT) in mitigating white matter hyperintensity (WMH) progression and whether these changes are sex dependent. This was an exploratory analysis of a randomized controlled trial assessing the effect of AT on cognition in people with vascular cognitive impairment. Participants were randomized to a 6 month AT or usual care (control [CON]) group. A subset completed magnetic resonance imaging to quantify WMH volume. Using an analysis of covariance model, we found a significant sex × group interaction (p = .03). Over the 6 month study, AT females demonstrated greater WMH progression than CON females (p = .05). Among males, there was no significant between-group difference (p = .31). Within the AT group, males demonstrated significantly less WMH progression than females (p = .01) at 6 months. Therefore, the effects of AT on WMH progression may vary by sex; that is, AT may curtail WMH progression in males but not females.