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2 results

  • 25 - Panic disorder and agoraphobia
  • from Section 4 - Treatment of anxiety: current status and controversial issues
  • Edited by Helen Blair Simpson, Columbia University, New York, Yuval Neria, Columbia University, New York, Roberto Lewis-Fernández, Columbia University, New York, Franklin Schneier, Columbia University, New York
  • Book: Anxiety Disorders
  • Published online: 10 November 2010
  • Print publication: 26 August 2010, pp 284-296
  • View abstract

    Summary

    This chapter reviews the methods for validating animal models of psychiatric disorders and discusses specific models of anxiety in mice. It demonstrates the importance of understanding the validity of a particular animal model, which assists in determining its clinical relevance in the context of careful interpretation. Currently, two main types of genetically modified mice are used in laboratory: knockout mice or knock-in mice and transgenic mice. The chapter reviews how state-of-the-art transgenic technology can be used to make animal models that allow us to consider the contribution of particular genes to anxiety-like behaviors. Several lines of evidence from human studies have implicated the 5-HT1A receptor in affective disorders. The studies of the 5-HT1A receptor provide an illustrative example of the strengths and weaknesses inherent in using the genetic technologies to investigate the pathophysiology of anxiety.