Two new families and three new genera and species of Crinoidea from the Icla and Belén formations, Bolivian Devonian, are described. The material is identified as Meperocrinus angelina n. gen. n. sp., from the Icla Formation of the Sub-Andina region, Tuberocrinus lapazensis n. gen. n. sp. and Aenigmaticumcrinus rochacamposi n. gen. n. sp., both from the Belén Formation of the Bolivian Altiplano. Meperocrinus angelina n. gen. n. sp. is an Emperocrinidae, a family described from the Silurian of the United States of America. Tuberocrinus lapazensis n. gen. n. sp. is assigned to a new family of Dimerocrinitacea, the Tuberocrinidae n. fam., which is closely related to Pterinocrinidae that already has representatives in Bolivia (Apurocrinus sucrei McIntosh), Argentina (Pterinocrinus? australis Haude), and Colombia (Bogotacrinus scheibei McIntosh). Aenigmaticumcrinus rochacamposi n. gen. n. sp. is also as assigned to a new family of Dimerocrinitacea, the Aenigmaticumcrinidae n. fam.; a family with very distinctive features. These data demonstrate that the Malvinokaffric crinoid fauna in Bolivia has a mixed origin, with forms that arrived in South America from Europe (Old World Realm) and United States of America (Eastern America Realm) during the late Silurian or earliest Devonian, as well as a local stock, which evolved to highly endemic lineages.