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Thwaites (Aeronaut. Q., vol. 1, 1949, pp. 245–280) developed an approximate method for determining the evolution of laminar boundary layers. The approximation follows from an assumption that the growth of a laminar boundary layer in the presence of pressure gradients could be parameterized solely as a function of the Holstein–Bohlen flow parameter, thus reducing the von Kármán momentum integral to a first-order ordinary differential equation. This method is useful for the analysis of laminar flows, and in computational potential flow solvers to account for the viscous effects. In this work, an approximate method for determining the momentum thickness of a two-dimensional, turbulent boundary layer is proposed following Thwaites’ work. It is shown that the method provides good estimates of the momentum thickness for multiple boundary layers, including both favourable and adverse pressure gradient effects, up to the point of separation. In the limit of high Reynolds numbers, it is possible to derive a criterion for the onset of separation from the proposed model, which is shown to be in agreement with prior empirical observations (Alber, 9th Aerospace Sciences Meeting, 1971). The sensitivity of the separation location with respect to upstream perturbations is also analysed through this model for the NASA/Boeing speed bump and the transonic Bachalo–Johnson bump.
Educational attainment (EduA) is correlated with life outcomes, and EduA itself is influenced by both cognitive and non-cognitive factors. A recent study performed a ‘genome-wide association study (GWAS) by subtraction,’ subtracting genetic effects for cognitive performance from an educational attainment GWAS to create orthogonal ‘cognitive’ and ‘non-cognitive’ factors. These cognitive and non-cognitive factors showed associations with behavioral health outcomes in adults; however, whether these correlations are present during childhood is unclear.
Methods
Using data from up to 5517 youth (ages 9–11) of European ancestry from the ongoing Adolescent Brain Cognitive DevelopmentSM Study, we examined associations between polygenic scores (PGS) for cognitive and non-cognitive factors and cognition, risk tolerance, decision-making & personality, substance initiation, psychopathology, and brain structure (e.g. volume, fractional anisotropy [FA]). Within-sibling analyses estimated whether observed genetic associations may be consistent with direct genetic effects.
Results
Both PGSs were associated with greater cognition and lower impulsivity, drive, and severity of psychotic-like experiences. The cognitive PGS was also associated with greater risk tolerance, increased odds of choosing delayed reward, and decreased likelihood of ADHD and bipolar disorder; the non-cognitive PGS was associated with lack of perseverance and reward responsiveness. Cognitive PGS were more strongly associated with larger regional cortical volumes; non-cognitive PGS were more strongly associated with higher FA. All associations were characterized by small effects.
Conclusions
While the small sizes of these associations suggest that they are not effective for prediction within individuals, cognitive and non-cognitive PGS show unique associations with phenotypes in childhood at the population level.
Twelve lacustrine sediment samples from a relict lake in the Kalla Glacier valley were co-dated using AMS radiocarbon (14C) and infrared stimulated luminescence (IRSL) dating methods. In general, the radiocarbon ages of bulk organic matter were older by a minimum of 1500 years compared to (age depth) modeled luminescence ages after fading corrections. This is observed for the first time in the lake sediments of High Himalayan Crystalline zone. A combination of lipid n-alkane data, Raman spectra and geochemical proxies suggested that this was due to ancient organic carbon (OCancient) that is a mixture of pre-aged (OCpre-aged) and petrogenic (OCpetro) organic carbon within older glacial moraine debris that served as sediment source to the lake. Raman spectra suggest the presence of moderate to highly graphitized OCpetro in all the profile samples. The OCpetro contributed 0.064 ± 0.032% to the sediment and the lake stored 2.5 ± 0.7 Gg OCpetro at variable rates during the last 16 kyr, with the mean burial flux 160 kg OCpetro yr−1. This study implies (1) employing another independent dating method in addition to radiocarbon method using bulk sediment organic matter, if the carbon content is low, to observe any discrepancy, and (2) a need to investigate on the fate of OCpetro as many such small lakes become relict in this region.
Although the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.
Methods
Data came from the Collaborative Study on the Genetics of Alcoholism (n = 3681; ages 11–36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones.
Results
Externalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20).
Conclusions
Behavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.
Substance use is a complex condition with multidimensional determinants. The present study aims to find the prevalence and determinants of substance use among young people attending primary healthcare centers in India.
Methods
A multicentric cross-sectional study was conducted across 15 states in India on 1,630 young people (10–24 years) attending primary health centers. The Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) was used to capture data on substance use. The degree of substance involvement was assessed and multivariate regression analysis was conducted to determine the risk factors of substance use.
Results
The prevalence of substance use was 32.8%, with a median substance initiation age of 18 years. Among the substance users, 75.5% began before completing adolescence. Tobacco (26.4%), alcohol (26.1%) and cannabis (9.5%) were commonly consumed. Sociodemographic determinants included higher age, male gender, urban residence, positive family history, northeastern state residence and lower socioeconomic class. Over 80% of users had moderate or high involvement.
Conclusions
High substance use prevalence among young people in Indian healthcare centers underscores the urgency of targeted intervention. Insights on determinants guide effective prevention strategies for this complex public health issue.
This chapter focuses on the propagation of vortex beams inside a GRIN medium. After an overview in Section 8.1 of polarization-related topics such as the Stokes vector and the Poincare sphere, the concept of a phase singularity is discussed in Section 8.2. This concept is used to form specific combinations of the modes that act as vortices with different state of polarizations. In Section 8.3, we discuss the techniques used for generating different types of vortex beams. Section 8.4 shows that a vortex beam also exhibits the self-imaging property during its propagation inside a GRIN medium. The impact of random mode coupling is also discussed in this section. Vortex-based applications of GRIN fibers are covered in Section 8.5.
This chapter provides an introduction to the subject known as gradient-index optics. In Section 1.1, we present a historical perspective on this subject before introducing the essential concepts needed in later chapters. Section 1.2 is devoted to various types of refractive-index profiles employed for making gradient index devices, with particular emphasis to the parabolic index profile because of its practical importance. In Section 1.3, we discuss the relevant properties of such devices such as optical losses, chromatic dispersion, and intensity dependence of the refractive index occurring at high power levels. The focus of Section 1.4 is on the materials and the techniques used for fabricating gradient-index devices in the form of a rod or a thin fiber
This chapter focuses on the effects of loss or gain in a graded-index (GRIN) medium. In Section 6.1, we discuss the impact of losses on the modes of such a medium. Section 6.2 considers the mechanisms used for providing optical gain inside a GRIN medium. Section 6.3 is devoted to Raman amplifiers and Raman lasers, built with GRIN fibers and pumped suitably to provide optical gain. Parametric amplifiers are discussed in Section 6.4, together with the phase matching required for four-wave mixing to occur. The focus of Section 6.5 is on amplifiers and lasers made by doping a GRIN fiber with rare-earth ions. Section 6.6 includes the nonlinear effects and describes the formation of spatial solitons and similaritons inside an active GRIN medium.
This chapter is devoted to the study of dispersive effects that affect short pulses inside a graded-index fiber. An equation governing the evolution of optical pulses inside a GRIN medium is found in Section 4.1. The dispersion parameters appearing in this equation change, depending on which mode is being considered. Section 4.2 focuses on the distortion of optical pulses resulting from differential group delay and group velocity dispersion. Section 4.3 deals with the effects of linear coupling among the modes, occurring because of random variations in the core’s shape and size along a fiber’s length. A non-modal approach is developed in Section 4.4 for the propagation of short optical pulses inside a GRIN medium. The focus of Section 4.5 is on the applications where optical pulses are sent through a GRIN rod or fiber
This chapter focuses on the impact of partial coherence on the propagation of optical beams inside a GRIN medium. Section 11.1 introduces the basic coherence-related concepts needed to understand the later material. Section 11.2 uses the evolution of cross-spectral density to study whether periodic self-imaging, an intrinsic property of a GRIN medium, is affected by partial coherence of an incoming beam. Section 11.3 employs the Gaussian-Schell model to discuss how the optical spectrum, the spectral intensity, and the degree of coherence associated with a Gaussian beam change with the beam’s propagation inside a GRIN medium. The focus of Section 11.4 is on Gaussian beams that are only partially polarized. The concept of the polarization matrix is used to study how the degree of polarization evolves when such a partially coherent Gaussian beam is transmitted through a GRIN medium
This chapter focuses on photonic analog of the spin-orbit coupling of electrons occurring inside a graded index medium. Section 9.1 describes two physical mechanisms that can produce changes in the state of polarization of an optical beam. The vectorial form of the wave equation is solved in Section 9.2 to introduce a path-dependent geometrical phase. The photonic analog of the spin-orbit coupling and its implications are also discussed in this section. Section 9.3 considers how the scalar LPlm modes change when the coupling term is taken into account. We treat this term first as a perturbation and then obtain the exact vector modes of a GRIN medium. A quantum approach is used in Section 9.4 to discuss various polarization-dependent effects.
Propagation of electromagnetic waves inside a GRIN medium is studied in this chapter. Section 2.1 starts with Maxwell’s equations and uses them to derive a wave equation in the frequency domain. A mode based technique is used in Section 2.2 for solving the wave equation for a GRIN device fabricated with a parabolic index profile. The properties of both the Hermite’Gauss and the Laguerre-Gauss modes are discussed. Section 2.3 is devoted to other power-law index profiles and employs the Wentzel-Kramers Brillouin method to discuss the properties of modes supported by them. We discuss in Section 2.4 the relative efficiency with which different modes are excited by an optical beam incident on a GRIN medium. The intermodal dispersive effects that become important for pulsed beams are also covered. Section 2.5 describes several non-modal techniques that can be used for studying wave propagation in GRIN media.
The focus of this chapter is on longitudinal variations of the refractive index and how such variations affect the propagation of light inside a GRIN medium. Section 7.1 describes the ray-optics and wave-optics techniques that can be used for this purpose. Section 7.2 focuses on tapered GRIN fibers and describes the impact of tapering on the periodic self-imaging for a few different tapering profiles. The analogy between a GRIN medium and a harmonic oscillator is exploited in Section 7.3 by employing several quantum-physics techniques for solving the GRIN problem. Section 7.4 is devoted to the case of periodic variations in the refractive index that are induced by changing the core’s radius of a GRIN fiber along its length in a periodic fashion.