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12 results

  • Workflow and Outcome of Thrombectomy in Late Time Window: A Pooled Multicenter Analysis

  • Ayoola Ademola, Fouzi Bala, Bijoy K. Menon, John Thornton, Ilaria Casetta, Stefania Nannoni, Mayank Goyal, Darragh Herlihy, Enrico Fainardi, Sarah Power, Valentina Saia, Aidan Hegarty, Giovanni Pracucci, Andrew Demchuk, Salvatore Mangiafico, Karl Boyle, Patrik Michel, Kevin A. Hildebrand, Tolulope T. Sajobi, Michael D. Hill, Danilo Toni, Sean Murphy, Beom Joon Kim, Mohammed A. Almekhlafi
  • Journal:
    Canadian Journal of Neurological Sciences , First View
    Published online by Cambridge University Press:
    19 April 2024, pp. 1-7
    • Article
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  • Background:

    We investigated the impact of workflow times on the outcomes of patients treated with endovascular thrombectomy (EVT) in the late time window.

    Methods:

    Individual patients’ data who underwent EVT in the late time window (onset to imaging >6 hours) were pooled from seven registries and randomized clinical trials. Multiple time intervals were analyzed. Mixed-effects logistic regression was used to estimate the likelihood of functional independence at 90 days (modified Rankin Scale 0–2). Mixed-effects negative binomial regression was used to evaluate the relationship between patient characteristics and workflow time intervals.

    Results:

    608 patients were included. The median age was 70 years (IQR: 58–71), 307 (50.5%) were female, and 310 (53.2%) had wake-up strokes. Successful reperfusion was achieved in 493 (81.2%) patients, and 262 (44.9%) achieved 90-day mRS 0–2. The estimated odds of functional independence decreased by 13% for every 30 minute delay from emergency department (ED) arrival to imaging time and by 7% from ED arrival to the end of EVT in the entire cohort. Also, the estimated odds of functional independence decreased by 33% for every 30 minute delay in the interval from arterial puncture to end of EVT, 16% in the interval from arrival in ED to end of EVT and 6% in the interval from stroke onset to end of EVT among patients who had a wake-up stroke.

    Conclusion:

    Faster workflow from ED arrival to end of EVT is associated with improved functional independence among stroke patients treated in the late window.

The Impact of Idealism
  • The Legacy of Post-Kantian German Thought
  • Volume 1, Philosophy and Natural Sciences
  • General editor Nicholas Boyle, Liz Disley
  • Edited by Karl Ameriks
  • Published online:
    05 December 2013
    Print publication:
    21 November 2013
  • The first study of its kind, The Impact of Idealism assesses the impact of classical German philosophy on science, religion and culture. This volume explores German Idealism's impact on philosophy and scientific thought. Fourteen essays, by leading authorities in their respective fields, each focus on the legacy of a particular idea that emerged around 1800, when the underlying concepts of modern philosophy were being formed, challenged and criticised, leaving a legacy that extends to all physical areas and all topics in the philosophical world. From British Idealism to phenomenology, existentialism, pragmatism and French postmodernism, the story of German Idealism's impact on philosophy is here interwoven with man's scientific journey of self-discovery in the nineteenth and early twentieth centuries – from Darwin to Nietzsche to Freud and beyond. Spanning the analytical and Continental divide, this first volume examines Idealism's impact on contemporary philosophical discussions.

  • 1 - Hidden Markov processes in the context of symbolic dynamics

  • Edited by Brian Marcus, University of British Columbia, Vancouver, Karl Petersen, University of North Carolina, Chapel Hill, Tsachy Weissman, Stanford University, California
  • Book:
    Entropy of Hidden Markov Processes and Connections to Dynamical Systems
    Published online:
    05 June 2011
    Print publication:
    26 May 2011, pp 5-71

  • Summary

    Abstract. In an effort to aid communication among different fields and perhaps facilitate progress on problems common to all of them, this article discusses hidden Markov processes from several viewpoints, especially that of symbolic dynamics, where they are known as sofic measures or continuous shift-commuting images of Markov measures. It provides background, describes known tools and methods, surveys some of the literature, and proposes several open problems.

    Introduction

    Symbolic dynamics is the study of shift (and other) transformations on spaces of infinite sequences or arrays of symbols and maps between such systems. A symbolic dynamical system, with a shift-invariant measure, corresponds to a stationary stochastic process. In the setting of information theory, such a system amounts to a collection of messages. Markov measures and hidden Markov measures, also called sofic measures, on symbolic dynamical systems have the desirable property of being determined by a finite set of data. But not all of their properties, for example the entropy, can be determined by finite algorithms. This article surveys some of the known and unknown properties of hidden Markov measures that are of special interest from the viewpoint of symbolic dynamics. To keep the article self contained, necessary background and related concepts are reviewed briefly. More can be found in [47, 56, 55, 71].

    We discuss methods and tools that have been useful in the study of symbolic systems, measures supported on them, and maps between them.