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Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial – CORRIGENDUM
Colleen Loo, Nick Glozier, David Barton, Bernhard T. Baune, Natalie T. Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B. Mitchell, Michael Berk, Gregory Carter, Maree Hackett, John Leyden, Sean Hood, Andrew A. Somogyi, Kyle Lapidus, Elizabeth Stratton, Kirsten Gainsford, Deepak Garg, Nicollette L. R. Thornton, Célia Fourrier, Karyn Richardson, Demi Rozakis, Anish Scaria, Cathrine Mihalopoulos, Mary Lou Chatterton, William M. McDonald, Philip Boyce, Paul E. Holtzheimer, F. Andrew Kozel, Patricio Riva-Posse, Anthony Rodgers
Journal:

The British Journal of Psychiatry / Volume 225 / Issue 2 / August 2024

Published online by Cambridge University Press:

14 October 2024, p. 349

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August 2024
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Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial
Colleen Loo, Nick Glozier, David Barton, Bernhard T. Baune, Natalie T. Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B. Mitchell, Michael Berk, Gregory Carter, Maree Hackett, John Leyden, Sean Hood, Andrew A. Somogyi, Kyle Lapidus, Elizabeth Stratton, Kirsten Gainsford, Deepak Garg, Nicollette L. R. Thornton, Célia Fourrier, Karyn Richardson, Demi Rozakis, Anish Scaria, Cathrine Mihalopoulos, Mary Lou Chatterton, William M. McDonald, Philip Boyce, Paul E. Holtzheimer, F. Andrew Kozel, Patricio Riva-Posse, Anthony Rodgers
Journal:

The British Journal of Psychiatry / Volume 223 / Issue 6 / December 2023

Published online by Cambridge University Press:

14 July 2023, pp. 533-541

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December 2023
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Background
Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed.
Aims
To assess the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. Trial registration: ACTRN12616001096448 at www.anzctr.org.au.
Method
This phase 3, double-blind, randomised, active-controlled multicentre trial was conducted at seven mood disorders centres in Australia and New Zealand. Participants received twice-weekly subcutaneous racemic ketamine or midazolam for 4 weeks. Initially, the trial tested fixed-dose ketamine 0.5 mg/kg versus midazolam 0.025 mg/kg (cohort 1). Dosing was revised, after a Data Safety Monitoring Board recommendation, to flexible-dose ketamine 0.5–0.9 mg/kg or midazolam 0.025–0.045 mg/kg, with response-guided dosing increments (cohort 2). The primary outcome was remission (Montgomery-Åsberg Rating Scale for Depression score ≤10) at the end of week 4.
Results
The final analysis (those who received at least one treatment) comprised 68 in cohort 1 (fixed-dose), 106 in cohort 2 (flexible-dose). Ketamine was more efficacious than midazolam in cohort 2 (remission rate 19.6% v. 2.0%; OR = 12.1, 95% CI 2.1–69.2, P = 0.005), but not different in cohort 1 (remission rate 6.3% v. 8.8%; OR = 1.3, 95% CI 0.2–8.2, P = 0.76). Ketamine was well tolerated. Acute adverse effects (psychotomimetic, blood pressure increases) resolved within 2 h.
Conclusions
Adequately dosed subcutaneous racemic ketamine was efficacious and safe in treating TRD over a 4-week treatment period. The subcutaneous route is practical and feasible.

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

John Leyden
Published online:

05 November 2015

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22 September 2011

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1799
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Although he had never set foot in Africa, Scottish poet and linguist John Leyden (1775–1811) decided to publish in 1799 this compilation on 'discoveries and settlements' there, drawing from the published works of explorers. His aim was 'to exhibit the progress of discoveries at this period in North and West Africa', giving descriptions of places such as Guinea, the Gold Coast, and Sierra Leone, as well as accounts of their people. He begins the work by discussing a meeting of the African Association on 9 June 1788, where a map depicted the interior of the continent as 'an extended blank'. Leyden attempts to provide information on those unknown areas by using the travel accounts of writers - including the Scots explorer Mungo Park - who had ventured into the African interior, to put together a narrative which makes this work a valuable collection of eighteenth-century accounts by European explorers in Africa.

Using a Microcomputer-Controlled Robot Arm as a General Purpose Sample Changer
John C. Russ, J. Christian Russ, Donald E. Leyden
Journal:

Advances in X-ray Analysis / Volume 27 / 1983

Published online by Cambridge University Press:

06 March 2019, pp. 427-432

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1983
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We have previously reported in these proceedings on the automation of Wavelength-Dispersive X-ray Fluorescence arid X-ray Diffraction Spectrometers using stepping motors, either installed in place of existing synchronous drive motors, or attached to existing gear or belt drive mechanisms that control the theta/two-theta positioning of the spectrometer. This technique is applicable to most types of instruments (successful adaptations to Philips, Siemens, GE/Diano, and Rigaku systems are working routinely at this writing).

Preface
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

Published online:

05 November 2015

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22 September 2011, pp v-xii

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1799
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CHAP. XII
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 288-360

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Discoveries & Settlements of the Europeans in Northern and Western Africa
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp iii-iv

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1799
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CHAP. III
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 15-22

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1799
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CHAP. VII
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 60-74

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1799
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CHAP. VI
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 33-59

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1799
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CHAP. X
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 174-239

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1799
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CHAP. II
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 6-15

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1799
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CHAP. XIV
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 420-442

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1799
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CHAP. I
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 1-5

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1799
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CHAP. XI
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 240-287

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1799
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Contents
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp xiii-xvi

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1799
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Frontmatter
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp i-ii

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1799
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CHAP. IV
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 22-33

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1799
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CHAP. VIII
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 75-105

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1799
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CHAP. XIII
John Leyden
Book:

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

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05 November 2015

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22 September 2011, pp 361-419

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1799
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Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial – CORRIGENDUM

Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial

A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century

Using a Microcomputer-Controlled Robot Arm as a General Purpose Sample Changer

Preface

CHAP. XII

Discoveries & Settlements of the Europeans in Northern and Western Africa

CHAP. III

CHAP. VII

CHAP. VI

CHAP. X

CHAP. II

CHAP. XIV

CHAP. I

CHAP. XI

Contents

Frontmatter

CHAP. IV

CHAP. VIII

CHAP. XIII

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A Historical and Philosophical Sketch of the Discoveries and Settlements of the Europeans in Northern and Western Africa, at the Close of the Eighteenth Century