To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The process of endometrial decidualization is a key event with direct relevance to very early pregnancy as well as subsequent pregnancy outcome. This chapter reviews the signals and pathways that control the morphological and biochemical differentiation of resident endometrial fibroblasts into secretory decidual cells. It discusses the functions of these cells at the feto-maternal interface. Decidual transformation of endometrial stromal cells can be faithfully recapitulated in culture and these in vitro studies have yielded invaluable insights into the signal pathways and downstream transcription factors that govern this differentiation process. Decidualizing stromal cells play an important role in local immunomodulation in many ways. The emergence in human beings of a cyclic decidual process has several major clinical implications; the most obvious of which is menstruation and its associated disorders. Decidualizing stromal cells and other cellular components in the superficial endometrial layer take part in menstrual shedding.
This chapter reviews the epidemiological evidence in support of a pathological link and discusses the implications for clinical management. Several epidemiological studies have investigated pregnancy outcome in singleton pregnancy after in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI). The lack of consensus diagnostic criteria and the heterogeneous nature of contemporary infertility investigations make it difficult to define the risk of adverse pregnancy outcome in relation to specific reproductive disorders, such as endometriosis or polycystic ovary syndrome (PCOS). In humans, the formation of a functional placenta requires invasion of fetal trophoblast not only into the maternal decidua and inner myometrium (interstitial invasion) but also into the maternal spiral arteries. Progesterone support improves pregnancy outcome after IVF treatment and two recent randomised trials have reported that progesterone also markedly reduces the incidence of preterm labour in at-risk women.
Email your librarian or administrator to recommend adding this to your organisation's collection.