The treatment of major depression remains problematic for several reasons. In particular, the therapeutic response to medications usually does not manifest itself until a week after administration has begun, and more than half the patients will not experience a full recovery with the first antidepressant drug administration. There are, however, some pharmacologic strategies that can accelerate antidepressant response. When facing a treatment-resistant depression, combination therapy offers a more time-efficient approach to achieve remission than drug substitution. These interventions have been devised on a better understanding of the basis for the therapeutic response obtained with the first- and second-generation antidepressants, and evidence derived from controlled clinical trials of their superior effectiveness is growing. The rationale for such approaches will be described in this article, as well as their advantages and potential inconveniences. Ongoing research in this field continues to fuel the development of novel, better-tolerated, and more effective pharmacotherapies for depression.

Twenty years ago the publication of Toward a Social Report by the United States Department of Health, Education and Welfare was hailed as a major forward step in developing indicators of conditions in society into a national system of social accounting of relevance to public policy. The resulting social indicators movement quickly mobilized able social scientists to produce a variety of indicators monitoring trends in their society, and internationally. National governments too began to sponsor new types of social reports. The years since have seen an apparent decline in the momentum of the social indicators movement. Hence, to evaluate developments, the Journal of Public Policy invited a number of distinguished pioneers in the movement in Europe and America to give their individual assessment of what has happened to social indicators.

The Epidermal Growth Factor (EGF) receptor is a tyrosine kinase that mediates the biological effects of ligands such as EGF and transforming growth factor alpha. An understanding of the molecular basis of its action has been hindered by a lack of structural and mutational data on the receptor. We have constructed comparative models of the four extracellular domains of the EGF receptor that are based on the structure of the first three domains of the insulin-like growth factor-1 (IGF-1) receptor. The first and third domains of the EGF receptor, L1 and L2, are right-handed beta helices. The second and fourth domains of the EGF receptor, S1 and S2, consist of the modules held together by disulfide bonds, which, except for the first module of the S1 domain, form rod-like structures. The arrangement of the L1 and S1 domains of the model are similar to that of the first two domains of the IGF-1 receptor, whereas that of the L2 and S2 domains appear to be significantly different. Using the EGF receptor model and limited information from the literature, we have proposed a number of regions that may be involved in the functioning of the receptor. In particular, the faces containing the large beta sheets in the L1 and L2 domains have been suggested to be involved with ligand binding of EGF to its receptor.

Advanced materials are being designed and tested for high-stress, high-cycle ball bearing applications. Important information about the tribological performance of these materials is gained through rolling contact fatigue (RCF) measurements. No such data have been reported to date for hybrid bearings consisting of titanium carbide (TiC)-coated REX20 steel balls and REX20 steel raceways. Chemical vapor deposition (CVD) was used for depositing the TiC coating. In this paper, we present the first report of the effects of RCF tests on this particular combination of hybrid bearings. Post-test characterizations of these bearings are discussed. Our investigations include plan-view and cross-sectional scanning electron microscopy, chemical compositional analyses, X-ray diffraction, and nano-indentation measurements. Results of these investigations provide a detailed understanding of the TiC coating on REX20 steel balls following extended rolling contact.