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The management of liver disease during pregnancy requires a multidisciplinary collaboration between obstetrician, hepatologist, anesthesiologist, and pediatrician in order to optimize outcome for mother and child. A number of blood tests are commonly used to screen for liver disease, confirm its presence, assess prognosis, and evaluate therapy. MRI is a safe imaging modality during pregnancy. Pregnancy-related liver diseases include hyperemesis gravidarum, intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy. Several viruses (e.g. hepatitis A (HAV) and E (HEV), herpes simplex virus (HSV), cytomegalovirus, Epstein-Barr viruses) that usually cause an acute self-limited hepatitis may occasionally result in acute liver failure. Hepatocellular adenomas arise in a normal liver, while a similar lesion in a cirrhotic liver is called a regenerative or dysplastic nodule. The differentiation of diseases related or unrelated to pregnancy is important to determine the management.