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Early identification of patients with novel corona virus disease 2019 (COVID-19) who may be at high mortality risk is of great importance.
In this retrospective study, we included all patients with COVID-19 at Huanggang Central Hospital from January 23 to March 5, 2020. Data on clinical characteristics and outcomes were compared between survivors and nonsurvivors. Univariable and multivariable logistic regression were used to explore risk factors associated with in-hospital death. A nomogram was established based on the risk factors selected by multivariable analysis.
A total of 150 patients were enrolled, including 31 nonsurvivors and 119 survivors. The multivariable logistic analysis indicated that increasing the odds of in-hospital death associated with higher Sequential Organ Failure Assessment score (odds ratio [OR], 3.077; 95% confidence interval [CI]: 1.848-5.122; P < 0.001), diabetes (OR, 10.474; 95% CI: 1.554-70.617; P = 0.016), and lactate dehydrogenase greater than 245 U/L (OR, 13.169; 95% CI: 2.934-59.105; P = 0.001) on admission. A nomogram was established based on the results of the multivariable analysis. The AUC of the nomogram was 0.970 (95% CI: 0.947-0.992), showing good accuracy in predicting the risk of in-hospital death.
This finding would facilitate the early identification of patients with COVID-19 who have a high-risk for fatal outcome.
The present investigation involves the synthesis of chitosan based composite sponges in view of their applications in wound dressing, antibacterial and haemostatic. A facile CO2 bubbles template freeze-drying method was developed for the fabrication of macroporous chitosan- poly(vinyl alcohol) (PVA) composite sponges with a typical porosity of 50% and pore size of 100-300 µm. The composite sponges show a high water absorption rate up to 60 times of its weight and a water vapor transmission rate of 30 ∼ 70g/m2 • h. Effects of the content of cross-linking agent and PVA on mechanical properties and moisture permeability were examined. Improved strength and flexibility of the chitosan sponges were observed with the presence of PVA. Further, the antibacterial and haemostatic activities have been demonstrated. The Chitosan/PVA sponges of high liquid absorption, appropriate moisture permeability, excellent antimicrobial and haemostatic activities have a great potential for wound dressing applications.
Transparent UV protective coatings were developed by incorporating nano-TiO2 into waterborne acrylic systems to provide long-term UV protection for UV sensitive cool color roofing. Water based high crystalline TiO2 nanoparticle suspension was prepared via a gel-sol method at a basic pH. The TiO2 nanoparticles have an average size of 20 nm and are stable against agglomeration. As prepared TiO2 nanosuspension is ready to be well dispersed in commercial waterborne acrylic resin system without extra surface modification. The fabricated TiO2/acrylic nanocomposite coating achieved an UV cut-off below 350 nm with a visible transmission greater than 85% at 700 nm. It is also demonstrated that surface modification of Nano-TiO2 with a SiO2 insulation layer would suppress the catalytic activity of Nano-TiO2 and improve the UV protection for UV and photocatalysis sensitive dyes.
Assembly of nanowires into ordered macroscopic structures has attracted great scientific interests in the past decade. In this work, we report a rapid low-cost scalable oil-water interfacial self assembly process for fabricating aligned Ag nanowires (AgNWs) films on solid substrates. This process is much simpler than the traditional Langmuir-Blodgett (LB) techniques and allows the assembly of one–dimensional Ag nanowires onto any solid substrates without extra pretreatment of the surface of silver nanowires or the solid substrate. The present aligned AgNW films can serve as robust surface-enhanced Raman scattering (SERS) sensors for chemical and bimolecular detection with improved spectra quality and demonstrated uniformity of SERS signal using R6G dye as probe.
High quality crystalline Si-C-N films on silicon substrate have been synthesized by bias-assisted hot filament chemical vapor deposition (CVD) using a gas mixture of nitrogen and methane. Scanning electron microscopy images show that the Si-C-N clusters are composed of many columnar crystals with hexagonal facets. X-ray diffraction and transmission electron microscopy analyses confirm the formation of Si-C-N crystals with lattice parameters a=7.06Å and c=2.72Å. First principles calculations are performed for β-Si3–nCnN4 (n=0,1,2,3). The calculated results support the experimental structural characterization and provide further insight into the property of the system. With increasing amount of C substitution, the bulk modulus progressively increases to 4.44 Mbar, comparable to that of diamond (4.43 Mbar), and both a and c are reduced but the ratio c/a shows little variation.
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