To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure email@example.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
This chapter summarizes trait-like (phenotypic) individual differences in neurobehavioral vulnerability to sleep deprivation, and current promising efforts to identify objective and biological markers of such differences. Sleep loss has increasingly become a major public health concern as population studies worldwide have found reduced sleep duration associated with increased risks of obesity, morbidity, and mortality. Available data suggest that common genetic variations (polymorphisms) involved in sleep-wake, circadian, and cognitive regulation may underlie symptomatic aspects of these large interindividual differences in neurobehavioral vulnerability to sleep deprivation in healthy adults. The impairing effects of sleep loss on neurobehavioral functions are the most well-established and conspicuous consequences of sleep deprivation. They include fatigue and sleepiness and unstable wakefulness; deficits in attention, working memory and executive functions; reduced mood-affect regulation; and increased accidents and injuries. Identifying who is likely to suffer neurobehavioral impairments would improve prevention of sleep deprivation and mitigation of its behavioral morbidity.