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In 2020, Baylor College of Medicine held a datathon to inform potential users of a new data warehouse, allow users to address clinical questions, identify warehouse capabilities and limitations, foster collaborations, and engage trainees. Senior faculty selected proposals based on feasibility and impact. Selectees worked with Information Technology for 2 months and presented findings. A survey of participants showed diverse levels of experience, high perceived value of the datathon, high rates of collaboration, and significant increases in knowledge. A datathon can promote familiarity with a new data warehouse, guide data warehouse improvement, and promote collaboration.
Stress caused by early weed competition is known to delay the rate of maize
development which may result in a decrease in kernel number. Kernel number
in maize is correlated negatively with the length of the anthesis-silking
interval (ASI). A short ASI has been identified as an easily measured,
visual trait which may identify enhanced drought tolerance in maize. Field
studies were conducted to test whether: (1) delaying weed control would
result in a lengthening of ASI in both a drought tolerant and non-drought
tolerant maize hybrid and (2) the presence of drought tolerance genetics
comes at a physiological cost, resulting in a greater yield reduction under
weedy conditions. In this study, the response of a drought tolerant hybrid
with its non-drought tolerant near-isoline was compared to seven different
timings of weed control using wheat as a surrogate competitor. Results
confirmed that there was no treatment by hybrid interaction at any site–yr
for any of the parameters evaluated. Delaying weed control reduced plant
height, leaf tip number, shifted and reduced biomass accumulation, kernel
number and grain yield and lengthened ASI for both hybrids. Although yield
losses occurred with the delay in weed control timing, no yield differences
were observed between hybrids suggesting that there was no additional
physiological cost associated with the drought tolerant traits. The drought
tolerant hybrid, however, was found to have a shorter ASI, lower kernel
number and higher kernel wt compared to the non-drought tolerant hybrid.
This study confirmed that delaying weed control can influence the length of
ASI, which is an important drought tolerant trait. The lengthening of ASI by
early weed competition resulted in a rate of yield loss of 0.13 T
ha−1 growing degree days (GDD)−1 when averaged
across both hybrids and all treatments.
This study investigated whether different types of corrective feedback (CF) in second language speech perception training have differential effects on second language speech production. One hundred Korean learners of English were assigned to five different groups and participated in eight computer-assisted perception training sessions focusing on English vowels. While no CF was provided to the control group, participants in the four treatment groups received one of three types of auditory CF or a visual type of CF. A pretest, an immediate posttest, and a delayed posttest each consisted of a production measurement at a controlled-speech level. Results revealed that the extent to which the participants’ production accuracy benefited from the perception training depended on CF type. In addition, by adopting the perception accuracy data by Lee and Lyster (2016b), the current study found that improvement in perception accuracy was a significant predictor of improvement in production accuracy.
To what extent do second language (L2) learners benefit from instruction that includes corrective feedback (CF) on L2 speech perception? This article addresses this question by reporting the results of a classroom-based experimental study conducted with 32 young adult Korean learners of English. An instruction-only group and an instruction + CF group were exposed to five 1-hr form-focused lessons that drew learners’ attention to the nonnative phonemic contrast /i/-/ɪ/, but only the instruction + CF group was given relevant feedback. Forced-choice identification tasks were completed by participants in a pretest, an immediate posttest, and a delayed posttest. The two groups showed similar accuracy on the pretest; however, the instruction + CF group outperformed the instruction-only group on the immediate and delayed posttests as well as on unfamiliar words. The significant predictors for these differences turned out to be perceptual accuracy vis-à-vis /ɪ/-natural and /ɪ/-synthesized sounds. These findings are discussed in terms of the pivotal role played by CF in developing accuracy in L2 speech perception.
To examine the prevalence of the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and the A2756G polymorphism of methionine synthase (MS), and their impact on antidepressant response.
Methods
We screened 224 subjects (52% female, mean age 39 ± 11 years) with SCID-diagnosed major depressive disorder (MDD), and obtained 194 genetic samples. 49 subjects (49% female, mean age 36 ± 11 years) participated in a 12-week open clinical trial of fluoxetine 20–60 mg/day. Association between clinical response and C677T and A2756G polymorphisms, folate, B12, and homocysteine was examined.
Results
Prevalence of the C677T and A2756G polymorphisms was consistent with previous reports (C/C = 41%, C/T = 47%, T/T = 11%, A/A = 66%, A/G = 29%, G/G = 4%). In the fluoxetine-treated subsample (n = 49), intent-to-treat (ITT) response rates were 47% for C/C subjects and 46% for pooled C/T and T/T subjects (nonsignificant). ITT response rates were 38% for A/A subjects and 60% for A/G subjects (nonsignificant), with no subjects exhibiting the G/G homozygote. Mean baseline plasma B12 was significantly lower in A/G subjects compared to A/A, but folate and homocysteine levels were not affected by genetic status. Plasma folate was negatively associated with treatment response.
Conclusion
The C677T and A2756G polymorphisms did not significantly affect antidepressant response. These preliminary findings require replication in larger samples.