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This chapter gives a brief description of the physical principles and the applications of the most commonly used lasers in subfertility surgery. The most common application of laser in subfertility surgery is endometriosis. The role of extensive surgery to treat deeply infiltrating endometriosis is debatable with the exception of endometriomas where excision seems to be superior to ablation regarding spontaneous pregnancy rate. The Nd:YAG laser has been used successfully to treat intrauterine adhesions with encouraging reproductive outcomes. The Nd:YAG laser has been widely used for hysteroscopic myomectomies as one- or two-stage procedure. Interstitial myolysis using a bare optic fiber of KTP, YAG, or diode laser has been reported as resolving symptoms and leaving a uterus capable of child bearing. The KTP or the Nd: YAG is the laser of choice for uterine septums, and the CO2 laser is used for vaginal septums.
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