At the turn of the twentieth century, Christian Scientists contended with ongoing allegations that their faith was more of a mental pathology than a religion. This article analyzes how the Church of Christ, Scientist, in particular its public relations branch the Committee on Publication, systematically contended with popular portrayals of Christian Science as a source or indicator of insanity. Two highly profiled court cases, both predicated on the purported insanity of a Christian Science woman and her attendant inability to manage her business affairs, are explored for their cultural effect on the promotion of the causal association between Christian Science and madness. This study employs newspaper clippings collected and archived by the Church's Committee on Publication as well as court records to argue for the salience of the insanity charge in shaping the early history of Christian Science and its public perception. As a religious tradition premised on divine healing and health, popular psychopathological interpretations of Christian Science were particularly subversive and functioned not only to discredit and undermine the religion's claims to healing but to forward societal fears that Christian Science study posed a unique threat to women's health. This examination draws attention to a dynamic historical exchange between the press and a new religious movement, as well as the polyvalent gendered presumptions embedded in popular charges of insanity in association with religion.