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Comparisons between the hominin or Neogene mammal fossil record and contemporaneous paleoclimate proxies have been commonplace since the pioneering studies of Elisabeth Vrba (1980, 1992, 1995a, 1995b). Vrba combined the new macroevolutionary theories of punctuated equilibrium and species selection (e.g., Eldredge and Gould, 1972; Vrba, 1985b) with emerging evidence for global climate change in the Plio-Pleistocene (e.g., Shackleton et al., 1990) to produce testable hypotheses of faunal turnover pulses in the Neogene fossil record. Vrba focused her analyses on the speciose Neogene bovids, rather than hominins, to ensure statistically robust results. Periods of bovid, and by inference hominin, turnover (origination, extinction and migration) between 2.8 and 2.5 Ma and at ~1.8 Ma were linked to episodes of global cooling seen in the global stable isotope records (Vrba, 1995b). Behrensmeyer et al. (1997) argued that Vrba’s turnover pulses were predominantly a product of sampling bias, by showing that bovid diversity and the number of bovid-bearing localities covaried. A study by deMenocal (1995) was the first to take Vrba’s hypothesis a step further by replacing the bovid fossil record with the hominin fossil record and suggesting that African aridity was behind the evolution of early Homo at approximately 2.0 Ma. This study took the hominin fossil record at face value despite its far greater incompleteness relative to the bovids, paving the way for a new wave of paleoclimatic theories. Potts (1996, 1998a, 1998b) took the debate further from Vrba’s original approach by dispensing with the notion of a shared climatic forcing between hominins and other mammals and proposed the Variability Selection (VS) hypothesis. The VS hypothesis is formulated around the idea that early hominins evolved unique adaptions for ecological versatility in response to climatic variability, so the fossil record of other mammal groups cannot be used to falsify the hypothesis. More recent iterations of the VS hypothesis (such as Maslin and Trauth, 2009; Shultz and Maslin, 2013; Maslin et al., 2014) also rely exclusively on the hominin fossil record as the explicit test case for their hypothesis.
Overall, American Protestants have demonstrated a strong commitment to global missions and missionary work throughout their history, urging the importance of converting others to Protestant Christianity. This emphasis began during the early days of American settlement by Europeans, with mission efforts among Native Americans, those of African descent, and eventually overseas groups. American Protestant mission efforts peaked during the modern missionary movement of the nineteenth century, with thousands of missionaries – including women and students – serving around the world with strong support from churches and mission boards. During the twentieth century, support for missions among mainline Protestants declined because of secularism and religious pluralism, while evangelical Protestants undertook innovative new forms of missions. Throughout the centuries, a commitment to missions has both reflected and shaped American Protestant self-understanding.
Five conjectures are proposed on the text of the third book of Propertius, one a slight alteration of an idea already proposed, four mainly original contributions: 1.23 postremo for post obitum, 4.18 supra uinctos for subter captos, 8.13 seu grege custodum for custodum gregibus (custodum grege seu Heinsius), 10.13 somnos for somnum, 11.40 adulta canis for adusta nota. One additional conjecture is made in passing on the text of Ovid, Epistulae ex Ponto 3.4.104, where duces probably ought to be read for uiros.
This chapter examines the relationship between the mining sector and environmental regulation, particularly whether stricter national environmental policies lead to increased environmental innovation in the mining sector, and whether higher stringency harms overall mining sector productivity. These hypotheses are tested using a panel dataset of 31 countries over 1990–2015, combining measures of EPS recently developed by the OECD, OECD data on mining sector productivity, and WIPO mining environmental patent-filing data. The chapter provides an overview of the mining sector’s relationship with the environment, environmental consequences of the extraction of the most economically important and prevalent minerals, and an overview of environmental regulation in each country, including mining-sector-specific regulations and more general environmental regulations, and mining environmental paten- filing patterns. The literature surrounding country-level environmental patent filing and the (weak) Porter hypothesis is reviewed, followed by a description of the dataset, its construction, and summary statistics, and results of the central regression analyses.
The continued dispersal of Palmer amaranth can impose detrimental impacts to cropping systems in Wisconsin. Our objective was to characterize the response of a recently introduced Palmer amaranth accession in southern WI to postemergence (POST) and preemergence (PRE) herbicides commonly used in corn and soybean. Greenhouse experiments were conducted with the WI putative herbicide-resistant accession (BRO), and two additional control accessions from Nebraska, a glyphosate-resistant (KEI2) and a glyphosate-susceptible (KEI3). Postemergence treatments were 2,4-D, atrazine, dicamba, glufosinate, glyphosate, imazethapyr, lactofen, and mesotrione at 1× and 3× label rates. Preemergence treatments were atrazine, mesotrione, metribuzin, S-metolachlor, and sulfentrazone at 0.5×, 1×, and 3× label rates. Plant survival of each accession was ≥ 63% after exposure to imazethapyr POST 3× rate. Survival of BRO and KEI2 was 44% (±13) and 50% (±13), respectively, after exposure to atrazine POST 3× rate. Survival of BRO was 69% (±12) after exposure to glyphosate POST 1× rate, whereas survival of KEI2 was 44% (±13) after exposure to glyphosate POST 3× rate. After exposure to 2,4-D POST 1× rate, KEI2 and KEI3 survival was 38% (±13) and 50% (±13), respectively. Survival of all accessions was ≤ 31% after exposure to 2,4-D POST 3× rate, or dicamba, glufosinate, lactofen, and mesotrione POST at either rate. Plant density reduction of KEI2 was 77% (±13) after exposure to atrazine PRE 1× rate, whereas density reduction of BRO was 56% (±13) after exposure to atrazine PRE 3× rate. Plant density reduction of all accessions was ≥ 94% after exposure to mesotrione PRE 1× and 3× rates, or metribuzin, S-metolachlor, and sulfentrazone PRE at either rate. Our results suggest that each accession is resistant (≥ 50% survival) to imazethapyr POST, that BRO and KEI2 are resistant to atrazine and glyphosate POST, and KEI2 and KEI3 are resistant to 2,4-D POST. The recently introduced BRO accession exhibited multiple resistance to imazethapyr, atrazine, and glyphosate POST. In addition, atrazine PRE was ineffective for BRO control, suggesting that diversified resistance management will be critical for its effective management.
Identification of treatment-specific predictors of drug therapies for bipolar disorder (BD) is important because only about half of individuals respond to any specific medication. However, medication response in pediatric BD is variable and not well predicted by clinical characteristics.
Methods
A total of 121 youth with early course BD (acute manic/mixed episode) were prospectively recruited and randomized to 6 weeks of double-blind treatment with quetiapine (n = 71) or lithium (n = 50). Participants completed structural magnetic resonance imaging (MRI) at baseline before treatment and 1 week after treatment initiation, and brain morphometric features were extracted for each individual based on MRI scans. Positive antimanic treatment response at week 6 was defined as an over 50% reduction of Young Mania Rating Scale scores from baseline. Two-stage deep learning prediction model was established to distinguish responders and non-responders based on different feature sets.
Results
Pre-treatment morphometry and morphometric changes occurring during the first week can both independently predict treatment outcome of quetiapine and lithium with balanced accuracy over 75% (all p < 0.05). Combining brain morphometry at baseline and week 1 allows prediction with the highest balanced accuracy (quetiapine: 83.2% and lithium: 83.5%). Predictions in the quetiapine and lithium group were found to be driven by different morphometric patterns.
Conclusions
These findings demonstrate that pre-treatment morphometric measures and acute brain morphometric changes can serve as medication response predictors in pediatric BD. Brain morphometric features may provide promising biomarkers for developing biologically-informed treatment outcome prediction and patient stratification tools for BD treatment development.
Portable oxygen concentrators (POCs) are medical devices that use physical means to separate oxygen from the atmosphere to produce concentrated, medical-grade gas. Providing oxygen to low-resources environments, such as austere locations, military combat zones, rural Emergency Medical Services (EMS), and during disasters, becomes expensive and logistically intensive. Recent advances in separation technology have promoted the development of POC systems ruggedized for austere use. This review provides a comprehensive summary of the available data regarding POCs in these challenge environments.
Methods:
PubMed, Google Scholar, and the Defense Technical Information Center were searched from inception to November 2021. Articles addressing the use of POCs in low-resource settings were selected. Three authors were independently involved in the search, review, and synthesis of the articles. Evidence was graded using Oxford Centre for Evidence-Based Medicine guidelines.
Results:
The initial search identified 349 articles, of which 40 articles were included in the review. A total of 724 study subjects were associated with the included articles. There were no Level I systematic reviews or randomized controlled trials.
Discussion:
Generally, POCs are a low-cost, light-weight tool that may fill gaps in austere, military, veterinary, EMS, and disaster medicine. They are cost-effective in low-resource areas, such as rural and high-altitude hospitals in developing nations, despite relatively high capital costs associated with initial equipment purchase. Implementation of POC in low-resource locations is limited primarily on access to electricity but can otherwise operate for thousands of hours without maintenance. They provide a unique advantage in combat operations as there is no risk of explosive if oxygen tanks are struck by high-velocity projectiles. Despite their deployment throughout the battlespace, there were no manuscripts identified during the review involving the efficacy of POCs for combat casualties or clinical outcomes in combat. Veterinary medicine and animal studies have provided the most robust data on the physiological effectiveness of POCs. The success of POCs during the coronavirus disease 2019 (COVID-19) pandemic highlights the potential for POCs during future mass-casualty events. There is emerging technology available that combines a larger oxygen concentrator with a compressor system capable of refilling small oxygen cylinders, which could transform the delivery of oxygen in austere environments if ruggedized and miniaturized. Future clinical research is needed to quantify the clinical efficacy of POCs in low-resource settings.
The aim of this scoping review is to explore the evidence by which community service providers have integrated reablement models of staff training and client assessment into practice.
Background:
The concept of reablement, which has emerged during the last two decades globally, has recently been defined by health experts from 11 countries through a Delphi study. Reablement is seen as a way to support integrated frameworks that achieve person-centred, long-term care and assistance across community settings. International research indicates there is some evidence of developing models of reablement that include staff training and individual components of client assessment. However, evidence of integrating reablement into interdisciplinary practice continues to be sparse.
Methods:
The review adopted the preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) approach. Inclusion criteria for the review related to community care, primary care, long-term care, and residential care. Populations of interest included service providers, interdisciplinary staff, trainers, and assessors.
Results:
A total of 11 papers were reviewed. The studies varied in their approach to reablement training and client assessment frameworks. Three studies included assessment of staff well-being. All included evidence-based, person-centred components that can be integrated across health care settings. Single disciplinary approaches were used in all studies and some included training evaluation.
Conclusion:
This review has identified that currently reablement models are not yet embedded as frameworks for practice by community service providers in primary health care settings. Different programmes of training and assessment are being designed based on single disciplinary approaches and the context in which they are delivered. Further developmental work is required to integrate the components of discipline-specific training programmes within interdisciplinary frameworks. This will achieve not only an integrated framework for delivery across settings but also further the success of ‘ageing in place’ policy.
In this paper, we determine the homotopy types of the Morse complexes of certain collections of simplicial complexes by studying dominating vertices or strong collapses. We show that if K contains two leaves that share a common vertex, then its Morse complex is strongly collapsible and hence has the homotopy type of a point. We also show that the pure Morse complex of a tree is strongly collapsible, thereby recovering as a corollary a result of Ayala et al. (2008, Topology and Its Applications 155, 2084–2089). In addition, we prove that the Morse complex of a disjoint union
$K\sqcup L$
is the Morse complex of the join
$K*L$
. This result is used to compute the homotopy type of the Morse complex of some families of graphs, including Caterpillar graphs, as well as the automorphism group of a disjoint union for a large collection of disjoint complexes.
Recent legalization of industrial hemp in the United States has led to increased interest among stakeholders to produce hemp for grain and fiber. However, owing to the lack of herbicides registered for use in hemp, producers are left with limited weed management strategies. Moreover, much of the agricultural land that could be used to cultivate industrial hemp may be prone to carryover of previously applied residual herbicides or physical drift from herbicides sprayed nearby. Industrial hemp sensitivity to herbicides is not well documented. Dose–response studies were conducted under controlled conditions in Madison, WI, screening two industrial hemp grain cultivars for tolerance to 44 preemergence and postemergence herbicides commonly used in corn and soybean. Treatments consisted of herbicides applied at 0×, 0.125×, 0.25×, 0.50×, 0.75×, 1×, 2×, and 4× the recommended maximum labeled rates based on soil type. Preemergence applications were delivered immediately after planting, whereas postemergence applications took place when hemp plants reached 5 to 10 cm in height. Nontreated plants served as the control and were used to estimate percent biomass reduction; dose–response curves were generated. Biomass reduction was >50% for rates under the suggested label rate for 23 preemergence and 21 postemergence herbicides tested. All herbicides tested resulted in >25% biomass reduction at the 0.125× rate, except for clopyralid applied preemergence and postemergence and saflufenacil applied preemergence. This is concerning, as the label rates are determined for effective weed control and the mitigation of herbicide resistance. Overall, these results indicate that industrial hemp is very sensitive to most herbicides tested. Growers should consider herbicide use history and surrounding crops when determining industrial hemp field selection to prevent significant plant injury due to herbicide carryover and drift. Further research into alternative methods of weed control will be vital to establishing hemp as a dominant crop once again.
Inequalities in voter participation between groups of the population pose a problem for democratic representation. We use administrative data on 6.7 million registered voters to show that a previously-ignored characteristic of voters—access to a personal automobile—creates large disparities in in-person voting rates. Lack of access to a car depresses election day voter turnout by substantively large amounts across a variety of fixed-effects models that account for other environmental and voter characteristics. Car access creates the largest hindrance to voting for those people who live farther from the polls. These effects do not appear for absentee voting, suggesting a simple policy solution to solve large disparities in political participation. This study contributes to the theoretic understanding of political participation as well as the impact of potential policy reforms to solve participatory gaps.
Theoretical and conceptual frameworks are often underutilized in research, which may diminish understanding of the phenomena and contribute to the under-development of interventions. The topic of low/disparate rates of Advance Care Planning (ACP) among African Americans has been researched extensively; however, the use of theoretical and/or conceptual frameworks has not been reported. The purpose of this review is to describe theoretical and/or conceptual frameworks utilized in studies that investigated factors affecting perceptions of ACP or ACP rates among African Americans.
Methods
Utilizing a narrative, literature review process, themes were generated, applied, and described with frequencies across broad categories of study characteristics, framework categories and key constructs, mode of framework application, and quality of framework reporting.
Results
Four main types of frameworks were found with behavioral frameworks dominating the collection of studies. Complex, systems theoretical frameworks were less common. Framework use and reporting quality findings are described.
Significance of results
The problem of disparate rates of ACP among African Americans is nuanced and varied, stemming from both internal (e.g., personal, behavioral) and external factors (e.g., living conditions). While important and necessary to focus on internal, psychological factors, it is also vital to incorporate systems’ theories such as the Cumulative Disadvantage Theory to better understand and demonstrate inherent complexities. Recommendations for framework use are discussed for research and clinical application. Incorporating complexity science approaches and multi-systems theories may support multi-level modeling needed to understand this problem and reduce ACP disparities in this population.
It is usual to put the New Woman writer Sarah Grand alongside Oscar Wilde to mark their differences. However, this essay suggests that these two authors had more in common than at first appears, both with regards to the fashioning of their literary identities and to their literary productions. Grand's compendious best-selling novel The Heavenly Twins (1893) is usually seen as realist fiction, but its interlude titled “The Tenor and the Boy,” which was actually composed much earlier, presents a stand-alone narrative that owes more to the romance mode and is much more playful in tone and spirit. It also deals with the decadent theme of the secret double life, although crucially and dramatically Grand focuses on female subterfuge. After juxtaposing Wilde's “Lady Alroy” (1887), another text about the female double life, with Grand's interlude, I subsequently consider decadent qualities common to both “The Tenor and the Boy” and other Wildean texts including theatricality, doubling, gender ambiguity, and queer desire.
In the Internet era, people can encounter a vast array of political news outlets, many with which they are unfamiliar. These unknown media outlets are notable because they represent potential sources of misinformation and coverage with a distinctive slant. We use two large survey experiments to consider how source familiarity influences political communication. Although this demonstrates the public is averse to consuming news from unfamiliar media, we show that—conditional on exposure to them—unknown local and foreign media sources can influence public opinion to an extent similar to established mainstream news outlets on the same issues. This comparable effectiveness stems from the public’s charitable evaluations of the credibility of unfamiliar news sources and their relatively low trust in familiar mainstream media. We find avoidance of unknown news outlets, not resistance to their coverage, is the primary factor limiting their political influence.
Background: The IVS10+14 mutation in the microtubule-associated protein tau gene, MAPT, is a rare point mutation that dysregulates tau splicing resulting in pathological aggregation. This mutation has been identified in three families with severe neurodegenerative disease. We characterized the clinicopathological features of a fourth, Canadian family with the IVS10+14 MAPT mutation and compared them to previously reported families. Methods: Clinical and neuropathological records from three family members with the IVS10+14 MAPT mutation were reviewed. Neuropathological section from one available case were analyzed. Results: Considerable interfamilial phenotypic heterogeneity is reported in all cohorts that express the IVS10+14 MAPT mutation, with prominent motor, cognitive, behavioural, and respiratory symptoms. The Canadian cohort also expressed profound sensory and sleep abnormalities, not reported previously. In the two siblings with available neuropathological records, neuropathological changes ranged from mild to severe. Conclusions: All families expressing the IVS10+14 MAPT mutation display striking inter- and intrafamilial clinical and neuropathologic phenotypic variability. Our cohort adds sensory and sleep abnormalities as potential symptoms and illustrates a lack of clear clinicopathological correlates for these heterogenous symptoms.
Reference: Maxwell et al. 2021. Clinical and Neuropathological Variability in the Rare IVS10+14 Tau Mutation. Neurobiology of Aging. In Press. DOI: 10.1016/j.neurobiolaging.2021.01.004.
The UK has recently adopted a policy of granting digital-only proof of immigration status for certain groups of migrants. More than 4.5 million individuals are reliant on this form of status and the number is growing. In this paper, we argue that this policy, as currently operationalised, is unlawful as a result of its discriminatory impact. If it remains unchanged, the roots of digital discrimination in immigration policy and administration will be allowed to spread, with potentially disastrous consequences.
People working in long-term care homes (LTCH) face ethical dilemmas about how to minimize the risk of spread of COVID-19, while also minimizing psychological hardship and other harms of infection control measures on residents. The Dementia Isolation Toolkit (www.dementiaisolationtoolkit.com; DIT) was developed to address the gap in ethical guidance for LTCH on how to safely and effectively isolate people with dementia while supporting the personhood and well-being of residents. In this presentation, we will present the DIT and report on the results of a survey of LTCH staff in Ontario, Canada on their experiences isolating residents in LTCH and the use of the DIT in supporting person-centred isolation care.
Methods:
A link to an online survey was distributed to LTCH staff through provincial organizations and agencies as well as through social media and the DIT website. Inclusion criteria were LTCH staff working on-site at a LTCH since March 1, 2020, who had direct or indirect experience with the isolation/quarantine of LTCH residents. Results were summarized descriptively.
Results:
A broad sample of LTCH staff (n=207) participated in the survey, most of whom had experienced an outbreak in their LTCH. Dementia (96%) was the most important barrier to implementation of infection control measures in LTCH, followed by staff distress about the effects of isolation on residents (61%). Important facilitators for isolation included delivery of 1:1 activities in the resident’s room (81%) and designating essential caregivers to provide support (67%), while inadequate staffing levels were reported as a barrier (55%). 65% of respondents indicated some familiarity with the DIT, and of those who had used the toolkit, 62% found it helpful in supporting isolation care, particularly in developing care plans and making and communicating decisions. Of those who had used the DIT, 48% found it fairly or very helpful at reducing their level of distress.
Conclusions:
Isolation as an infection control and prevention (ICP) measure in LTCH environments can be harmful to residents and create moral distress in staff. ICP guidance and support of LTCH needs to address how to minimize these harms by providing dementia-specific guidance such as in the DIT.
A large and highly heterogeneous group of individuals conducts genetic and genomic research outside of traditional corporate and academic settings. They can be an important source of innovation, but their activities largely take place beyond the purview of existing regulatory systems for promoting safe and ethical practices. Historically the gene-targeting technology available for non-traditional biology (NTB) experiments has been limited, and therefore they have attracted little regulatory attention. New techniques such as CRISPR-cas9, however, may create a need for alternate governance approaches. This chapter explores whether alternate governance approaches might be needed and, if so, what governance approaches would be most likely to enable non-traditional experiments to be conducted safely and ethically.