Much discussion having arisen as to whether the Eastern or Western branch of the Indus was formerly the grand stream of the river, and likewise as to the route pursued by Alexander the Great through Sindh, a few remarks from me may perhaps be excused, although the subject is one from which little profit can be derived, and on which it behoves every one to speak with caution and diffidence. Having, however, travelled over a considerable portion of the country, and by personal observation and inquiry made myself acquainted with many circumstances bearing on this topic, I am induced to offer the following facts and surmises for the consideration of those who are in any way interested in the question affecting the route of the Macedonian conqueror; but before entering on this discussion, it will be as well to describe the general features of the Indus as they now exist, in its course through Sindh.