Tsetse populations and trypanosome prevalence in cattle were monitored from 1986 to 1993 in the Ghibe valley, south-west Ethiopia. From January 1991 to December 1993 between 2000 and 4000 cattle were treated at monthly intervals with a synthetic pyrethroid insecticide, cypermethrin (RS-alpha-cyano-3-phenoxy- benzyl [1RS]-cis, trans -3-[2,2-dichlorovinyl]-2,2-dimethylcyclopropane carboxylate). An approximate dosage of 1 ml per 10 kg bodyweight was used to control tsetse flies (Glossina spp.). Treatments were given as ‘pour-on’ applications along the backlines of animals, using automatic drench-gun applicators. This resulted in a decline of 93% in the apparent density of G. pallidipes Austen. A reduction of 83% in the apparent density of G. morsitans submorsitans Newstead was also observed. This reduction was associated with a reduction in trypanosome prevalence in cattle of over 74% in 1993, despite a high level of resistance to all available trypanocidal drugs. The numbers of Stomoxys spp. (Diptera: Muscidae) and Tabanidae were also significantly reduced (P < 0.01).