The question is, what happens when the bone loses its ability for load-driven
adaptation, when damage is no longer repaired as it seems to be the case for bone loss
associated with age, medication or disease? In this study, we tempt to show how damage
can influence the remodeling process. A thermodynamic theoretical framework is therefore
provided as a basis for a consistent formulation of bone remodeling involving a
chemical reaction and mass transfer between two constituents in presence of microcracks.