The El Niño–Southern Oscillation (ENSO) signal in coastal Antarctic precipitation is evaluated using deuterium-excess data measured from an ice core located at Victoria Lower Glacier (VLG) Dome, McMurdo Dry Valleys. Recent studies suggest that interannual variations in the intensity and position of the Amundsen Sea low, a low-pressure centre that controls moisture flux in the West Antarctic sector, is modulated by the ENSO. Deuterium-excess values from the VLG ice core, which serve as a proxy for changes in regional moisture flux, exhibit oscillations of equivalent duration to those observed in the Southern Oscillation Index (SOI). Results of cross-spectral analyses show that temporal fluctuations in deuterium excess and the SOI covary and are coherent at ~4.9, 3.6, 3.0, 2.6, 2.4 and 2.0 year frequencies between 1950 and 2000. We ascribe this covariance to shifts in the source and transport pathway of precipitation that is deposited in coastal Victoria Land as a consequence of ENSO’s influence. High values of deuterium excess are consistent with increased meridional flow carrying warm, moist air southward across the Ross Sea when the low-pressure centre is positioned to the north of the Ross Ice Shelf (La Niña mode). Low deuterium-excess values, which reflect a more westerly to southerly flow across the West Antarctic ice sheet and Ross Ice Shelf leading to cooler and drier en-route conditions, occur when the low-pressure centre is positioned above the Amundsen Sea (El Niño mode).