The push in consumer electronics over past decades has been toward smaller, faster, and cheaper products but with same or improved capabilities. The consumer imaging world has been no exception with the integration, for example, of functional complementary metal-oxide-semiconductor (CMOS) cameras into ever smaller cellular phones. The CMOS sensors have continued to develop and improve with increasing numbers of smaller, more sensitive pixels with larger photo-response capacity providing higher dynamic range. This technological expansion has inevitably spilled over into even the scientific imaging world, such as in biological light microscopy. This advancement of consumer CMOS digital camera technology invites comparison of CMOS cameras with the current standard charge coupled device (CCD) cameras in scientific imaging.