We describe the curation and use of clay samples as part of the ceramic ecology program at the Florida Museum of Natural History's Ceramic Technology Laboratory (FLMNH-CTL). We outline the history of the comparative clay sample collection at the FLMNH-CTL and detail the standard operating procedure by which samples are processed, analyzed, and curated. We also provide examples of how the clay samples have been used in research projects as well as some of the challenges inherent to studies using such samples. Our collection of processed clays and associated thin sections, which is curated in perpetuity, represents a valuable resource for ongoing and future lab endeavors and is available to other researchers focusing on Florida and adjacent regions.