A new species of Ophiomisidium is described and regards about reproduction are presented. It is the first species in the genus to posses, apparently, a brooding development. Very few specimens of species of Ophiomisidium have previously been collected, but over 3000 specimens of the new species were collected on the continental shelf and slope (60–810 m depth) off southern Brazil. They were obtained during the REVIZEE Programme, the first extensive surveys to examine Brazilian ophiuroids from depths greater than 200 m.