Book contents
- Frontmatter
- Dedication
- Contents
- The Mutant Timeline
- Prologue : The World On Notice
- 1 I’m Quite Glad That I Wasn’T First
- 2 The China Dream
- 3 The Best Humans haven't been Produced Yet
- 4 Winner Takes All
- 5 Look at those Muscles, Look at that Butt
- 6 A Moral Choice
- 7 Will I have to Mortgage My House?
- 8 The Cancer Moonshot
- 9 Free Health Care for All
- 10 Silence = Death
- 11 Immortality has to be the Goal
- 12 I don't want to Walk. I want to Fly
- 13 High-Quality Children
- 14 #Transracial
- 15 American Medicine and only for You
- 16 He was Busy, Busy. Always doing Research
- 17 A Hammer, Looking for a Nail
- 18 Beautiful Lies
- 19 Two Healthy Baby Girls?
- 20 Mixed Wisdom
- 21 They are Moving Forward
- 22 Chinese Scientists are Creating Crispr Babies
- 23 Bubbles Vanishing into Air
- 24 The Hourse has Already Bolted
- Epilogue: We have Never Been Human
- Acknowledgments
- Notes
- Index
8 - The Cancer Moonshot
Published online by Cambridge University Press: 18 December 2021
- Frontmatter
- Dedication
- Contents
- The Mutant Timeline
- Prologue : The World On Notice
- 1 I’m Quite Glad That I Wasn’T First
- 2 The China Dream
- 3 The Best Humans haven't been Produced Yet
- 4 Winner Takes All
- 5 Look at those Muscles, Look at that Butt
- 6 A Moral Choice
- 7 Will I have to Mortgage My House?
- 8 The Cancer Moonshot
- 9 Free Health Care for All
- 10 Silence = Death
- 11 Immortality has to be the Goal
- 12 I don't want to Walk. I want to Fly
- 13 High-Quality Children
- 14 #Transracial
- 15 American Medicine and only for You
- 16 He was Busy, Busy. Always doing Research
- 17 A Hammer, Looking for a Nail
- 18 Beautiful Lies
- 19 Two Healthy Baby Girls?
- 20 Mixed Wisdom
- 21 They are Moving Forward
- 22 Chinese Scientists are Creating Crispr Babies
- 23 Bubbles Vanishing into Air
- 24 The Hourse has Already Bolted
- Epilogue: We have Never Been Human
- Acknowledgments
- Notes
- Index
Summary
Carl June—the scientist who was questioned about social inequality, ethics, and scientific profiteering by the Recombinant DNA Advisory Committee—passes as white, though in an earlier era he might have been excluded from science by the one-drop rule. His great-great-grandmother was black. When we talked I noted that the Cancer Survivor Hall of Fame was an uncomfortably white space. “The recruitment thing is a very complex issue,” June said. As a result of abuse in the recent past, many historically disadvantaged communities have a “healthy distrust” of science. “And then there's the fact to actually be on a trial you have to not be in poverty,” he continued. The uninsured and urban poor cannot afford routine cancer screenings, much less the other out-of-pocket medical expenses associated with an experiment. “Like 25 percent of the African Americans in Philadelphia are below the poverty line. So they can't go on trials because, you know, they’re just trying to survive.”
In addition to dedicating his life to curing cancer, Carl June has worked throughout his career to promote diversity in science, giving opportunities to young researchers from Asia and Latin America as well as minority communities in the United States. He is also in a position to reap huge prof-its and professional accolades from his medical breakthroughs. From this position of relative privilege and power, June could be doing more to give disadvantaged communities access to experimental medicine.
As I talked with Carl June about his latest research—the first CRISPR experiment approved in the United States—I came to realize that gene editing was the least interesting part of the story. The new study aimed to develop a cancer cure by improving the design of CAR T cells—a living therapy on the frontier of personalized medicine. The special T cells that treated Nicholas Wilkins and others in the hall of fame were genetically modified to have chimeric antigen receptors (CARs) on their surface. The chimera of Greek mythology was a fire-breathing monster with a lion's head, a goat's body, and a serpent's tail. The chimeric receptors on the T cells were simply a synthetic collection of different molecular parts that had been designed to target particular kinds of cancer.
- Type
- Chapter
- Information
- The Mutant ProjectInside the Global Race to Genetically Modify Humans, pp. 88 - 92Publisher: Bristol University PressPrint publication year: 2021